DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P00374)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	3
Number of reactions:	3

Search results (UniProt accession: P00374)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013456	DHFR	P00374	1.5.1.3	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism Cell Cycle	R-HSA-1497794 ( R-HSA-1474151 ) R-HSA-1497794 Reaction Name: Salvage - BH2 is reduced to BH4 by DHFR See in Reactome R-HSA-8961874 ( R-HSA-69205 ) R-HSA-8961874 Reaction Name: DHFR gene expression is stimulated by E2F1 See in Reactome R-HSA-9709098 ( R-HSA-196757 ) R-HSA-9709098 Reaction Name: DHFR dimer reduces FOLA to DHF See in Reactome