DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O96017)

Number of enzymes:	1
Number of disease:	5
Number of reactomes:	8
Number of reactions:	10

Search results (UniProt accession: O96017)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0023122	CHEK2	O96017	2.7.11.1	R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-75035 R-HSA-75035 Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle	R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683774 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683774 Reaction Name: p-T68-CHEK2 dimerizes See in Reactome R-HSA-5683792 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683792 Reaction Name: p-T68-CHEK2 autophosphorylates See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-6804266 ( R-HSA-6804760 ) R-HSA-6804266 Reaction Name: CHEK2 phosphorylates TTC5 See in Reactome R-HSA-69608 ( R-HSA-69601 ) R-HSA-69608 Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2 See in Reactome R-HSA-69685 ( R-HSA-6804756; R-HSA-69541 ) R-HSA-69685 Reaction Name: CHEK2 phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75809 ( R-HSA-69473; R-HSA-75035 ) R-HSA-75809 Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2 See in Reactome
MONDO:0012233	CHEK2	O96017	2.7.11.1	R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-75035 R-HSA-75035 Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle	R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683774 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683774 Reaction Name: p-T68-CHEK2 dimerizes See in Reactome R-HSA-5683792 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683792 Reaction Name: p-T68-CHEK2 autophosphorylates See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-6804266 ( R-HSA-6804760 ) R-HSA-6804266 Reaction Name: CHEK2 phosphorylates TTC5 See in Reactome R-HSA-69608 ( R-HSA-69601 ) R-HSA-69608 Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2 See in Reactome R-HSA-69685 ( R-HSA-6804756; R-HSA-69541 ) R-HSA-69685 Reaction Name: CHEK2 phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75809 ( R-HSA-69473; R-HSA-75035 ) R-HSA-75809 Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2 See in Reactome
MONDO:0016996	CHEK2	O96017	2.7.11.1	R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-75035 R-HSA-75035 Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle	R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683774 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683774 Reaction Name: p-T68-CHEK2 dimerizes See in Reactome R-HSA-5683792 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683792 Reaction Name: p-T68-CHEK2 autophosphorylates See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-6804266 ( R-HSA-6804760 ) R-HSA-6804266 Reaction Name: CHEK2 phosphorylates TTC5 See in Reactome R-HSA-69608 ( R-HSA-69601 ) R-HSA-69608 Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2 See in Reactome R-HSA-69685 ( R-HSA-6804756; R-HSA-69541 ) R-HSA-69685 Reaction Name: CHEK2 phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75809 ( R-HSA-69473; R-HSA-75035 ) R-HSA-75809 Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2 See in Reactome
MONDO:0002629	CHEK2	O96017	2.7.11.1	R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-75035 R-HSA-75035 Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle	R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683774 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683774 Reaction Name: p-T68-CHEK2 dimerizes See in Reactome R-HSA-5683792 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683792 Reaction Name: p-T68-CHEK2 autophosphorylates See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-6804266 ( R-HSA-6804760 ) R-HSA-6804266 Reaction Name: CHEK2 phosphorylates TTC5 See in Reactome R-HSA-69608 ( R-HSA-69601 ) R-HSA-69608 Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2 See in Reactome R-HSA-69685 ( R-HSA-6804756; R-HSA-69541 ) R-HSA-69685 Reaction Name: CHEK2 phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75809 ( R-HSA-69473; R-HSA-75035 ) R-HSA-75809 Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2 See in Reactome
MONDO:0016419	CHEK2	O96017	2.7.11.1	R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-75035 R-HSA-75035 Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Cell Cycle	R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683774 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683774 Reaction Name: p-T68-CHEK2 dimerizes See in Reactome R-HSA-5683792 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683792 Reaction Name: p-T68-CHEK2 autophosphorylates See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-6804266 ( R-HSA-6804760 ) R-HSA-6804266 Reaction Name: CHEK2 phosphorylates TTC5 See in Reactome R-HSA-69608 ( R-HSA-69601 ) R-HSA-69608 Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2 See in Reactome R-HSA-69685 ( R-HSA-6804756; R-HSA-69541 ) R-HSA-69685 Reaction Name: CHEK2 phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75809 ( R-HSA-69473; R-HSA-75035 ) R-HSA-75809 Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2 See in Reactome