DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O95140)

Number of enzymes:	1
Number of disease:	9
Number of reactomes:	3
Number of reactions:	6

Search results (UniProt accession: O95140)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018995	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0010877	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0011002	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0007908	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0012231	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0014906	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0000437	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0019549	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0004183	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome