DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O94953)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	3
Number of reactions:	14

Search results (UniProt accession: O94953)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0060596	KDM4B	O94953	1.14.11.66	R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome	R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization DNA Repair Signal Transduction	R-HSA-4724279 ( R-HSA-3214842 ) R-HSA-4724279 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 See in Reactome R-HSA-5661120 ( R-HSA-3214842 ) R-HSA-5661120 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-9011949 ( R-HSA-9018519 ) R-HSA-9011949 Reaction Name: KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers See in Reactome R-HSA-9011952 ( R-HSA-9018519 ) R-HSA-9011952 Reaction Name: ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers See in Reactome R-HSA-9011966 ( R-HSA-9018519 ) R-HSA-9011966 Reaction Name: Estrogen-responsive KDM4B gene expression See in Reactome