DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O60566)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	10
Number of reactions:	24

Search results (UniProt accession: O60566)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009759	BUB1B	O60566	2.7.11.1	R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-141430 R-HSA-141430 Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex See in Reactome R-HSA-179409 R-HSA-179409 Reactome Name: APC-Cdc20 mediated degradation of Nek2A See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-141405 R-HSA-141405 Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Signal Transduction	R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141423 ( R-HSA-141430 ) R-HSA-141423 Reaction Name: Binding of the MCC complex to the APC/C complex See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141437 ( R-HSA-141430 ) R-HSA-141437 Reaction Name: Formation of the MCC complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-174104 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174104 Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex See in Reactome R-HSA-174171 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174171 Reaction Name: Association of Cyclin A with the APC/C See in Reactome R-HSA-174238 ( R-HSA-176409 ) R-HSA-174238 Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 See in Reactome R-HSA-174255 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-179410 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179410 Reaction Name: Association of Nek2A with MCC:APC/C See in Reactome R-HSA-179417 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179417 Reaction Name: Multiubiquitination of Nek2A See in Reactome R-HSA-179421 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179421 Reaction Name: Degradation of multiubiquitinated Nek2A See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome
MONDO:0005575	BUB1B	O60566	2.7.11.1	R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-141430 R-HSA-141430 Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex See in Reactome R-HSA-179409 R-HSA-179409 Reactome Name: APC-Cdc20 mediated degradation of Nek2A See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-141405 R-HSA-141405 Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Signal Transduction	R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141423 ( R-HSA-141430 ) R-HSA-141423 Reaction Name: Binding of the MCC complex to the APC/C complex See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141437 ( R-HSA-141430 ) R-HSA-141437 Reaction Name: Formation of the MCC complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-174104 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174104 Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex See in Reactome R-HSA-174171 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174171 Reaction Name: Association of Cyclin A with the APC/C See in Reactome R-HSA-174238 ( R-HSA-176409 ) R-HSA-174238 Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 See in Reactome R-HSA-174255 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-179410 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179410 Reaction Name: Association of Nek2A with MCC:APC/C See in Reactome R-HSA-179417 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179417 Reaction Name: Multiubiquitination of Nek2A See in Reactome R-HSA-179421 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179421 Reaction Name: Degradation of multiubiquitinated Nek2A See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome
MONDO:0008304	BUB1B	O60566	2.7.11.1	R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-141430 R-HSA-141430 Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex See in Reactome R-HSA-179409 R-HSA-179409 Reactome Name: APC-Cdc20 mediated degradation of Nek2A See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-141405 R-HSA-141405 Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Signal Transduction	R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141423 ( R-HSA-141430 ) R-HSA-141423 Reaction Name: Binding of the MCC complex to the APC/C complex See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141437 ( R-HSA-141430 ) R-HSA-141437 Reaction Name: Formation of the MCC complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-174104 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174104 Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex See in Reactome R-HSA-174171 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174171 Reaction Name: Association of Cyclin A with the APC/C See in Reactome R-HSA-174238 ( R-HSA-176409 ) R-HSA-174238 Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 See in Reactome R-HSA-174255 ( R-HSA-174184; R-HSA-176409 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-179410 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179410 Reaction Name: Association of Nek2A with MCC:APC/C See in Reactome R-HSA-179417 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179417 Reaction Name: Multiubiquitination of Nek2A See in Reactome R-HSA-179421 ( R-HSA-176409; R-HSA-179409 ) R-HSA-179421 Reaction Name: Degradation of multiubiquitinated Nek2A See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome