DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O60331)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	4
Number of reactions:	5

Search results (UniProt accession: O60331)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0012656	PIP5K1C	O60331	2.7.1.68	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Developmental Biology Vesicle-mediated transport	R-HSA-1675773 ( R-HSA-1660499 ) R-HSA-1675773 Reaction Name: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane See in Reactome R-HSA-1676082 ( R-HSA-1660499; R-HSA-6811558 ) R-HSA-1676082 Reaction Name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane See in Reactome R-HSA-1676145 ( R-HSA-1660499 ) R-HSA-1676145 Reaction Name: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane See in Reactome R-HSA-399936 ( R-HSA-399955 ) R-HSA-399936 Reaction Name: Inhibition of integrin activation by sequestering PIP5KIgamma See in Reactome R-HSA-8868066 ( R-HSA-8856828 ) R-HSA-8868066 Reaction Name: PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 See in Reactome