DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O15118)

Number of enzymes:	1
Number of disease:	7
Number of reactomes:	1
Number of reactions:	2

Search results (UniProt accession: O15118)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0003441	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0009757	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016310	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016306	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016307	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016308	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome
MONDO:0016309	NPC1	O15118	-	R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8876484 ( R-HSA-8964038 ) R-HSA-8876484 Reaction Name: NPC2 transfers CHOL to NPC1 See in Reactome R-HSA-8876485 ( R-HSA-8964038 ) R-HSA-8876485 Reaction Name: CHOL translocates from lysosome membrane to ER membrane See in Reactome