DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O15054)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	6

Search results (UniProt accession: O15054)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0032790	KDM6B	O15054	1.14.11.68	R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Cellular responses to stimuli	R-HSA-3222546 ( R-HSA-2559580 ) R-HSA-3222546 Reaction Name: AP-1 complex stimulates KDM6B transcription See in Reactome R-HSA-3222593 ( R-HSA-2559580 ) R-HSA-3222593 Reaction Name: KDM6B demethylates H3K27me3 on p16INK4A promoter See in Reactome R-HSA-3223200 ( R-HSA-2559580 ) R-HSA-3223200 Reaction Name: Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription See in Reactome R-HSA-4754187 ( R-HSA-3214842 ) R-HSA-4754187 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 See in Reactome R-HSA-5661121 ( R-HSA-3214842 ) R-HSA-5661121 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 See in Reactome R-HSA-8979071 ( R-HSA-2559580 ) R-HSA-8979071 Reaction Name: KDM6B binds iron See in Reactome