DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O14965)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	8
Number of reactions:	17

Search results (UniProt accession: O14965)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0019438	AURKA	O14965	2.7.11.1	R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8854521 R-HSA-8854521 Reactome Name: Interaction between PHLDA1 and AURKA See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174088 ( R-HSA-174178 ) R-HSA-174088 Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174195 ( R-HSA-174178 ) R-HSA-174195 Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-4655404 ( R-HSA-4615885 ) R-HSA-4655404 Reaction Name: SUMOylation of AURKA with SUMO1 See in Reactome R-HSA-6791235 ( R-HSA-6804114 ) R-HSA-6791235 Reaction Name: GADD45A binds AURKA See in Reactome R-HSA-6805103 ( R-HSA-6804756 ) R-HSA-6805103 Reaction Name: AURKA phosphorylates TP53 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8853429 ( R-HSA-8854521 ) R-HSA-8853429 Reaction Name: PHLDA1 binds AURKA See in Reactome R-HSA-8853444 ( R-HSA-8854521 ) R-HSA-8853444 Reaction Name: AURKA phosphorylates PHLDA1 See in Reactome R-HSA-8853496 ( R-HSA-8854050 ) R-HSA-8853496 Reaction Name: SCF:FBXL7 binds AURKA See in Reactome R-HSA-8854041 ( R-HSA-8854050 ) R-HSA-8854041 Reaction Name: SCF-FBXL7 ubiquitinates AURKA See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome
MONDO:0009693	AURKA	O14965	2.7.11.1	R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8854521 R-HSA-8854521 Reactome Name: Interaction between PHLDA1 and AURKA See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174088 ( R-HSA-174178 ) R-HSA-174088 Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174195 ( R-HSA-174178 ) R-HSA-174195 Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-4655404 ( R-HSA-4615885 ) R-HSA-4655404 Reaction Name: SUMOylation of AURKA with SUMO1 See in Reactome R-HSA-6791235 ( R-HSA-6804114 ) R-HSA-6791235 Reaction Name: GADD45A binds AURKA See in Reactome R-HSA-6805103 ( R-HSA-6804756 ) R-HSA-6805103 Reaction Name: AURKA phosphorylates TP53 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8853429 ( R-HSA-8854521 ) R-HSA-8853429 Reaction Name: PHLDA1 binds AURKA See in Reactome R-HSA-8853444 ( R-HSA-8854521 ) R-HSA-8853444 Reaction Name: AURKA phosphorylates PHLDA1 See in Reactome R-HSA-8853496 ( R-HSA-8854050 ) R-HSA-8853496 Reaction Name: SCF:FBXL7 binds AURKA See in Reactome R-HSA-8854041 ( R-HSA-8854050 ) R-HSA-8854041 Reaction Name: SCF-FBXL7 ubiquitinates AURKA See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome