DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O14672)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	12
Number of reactions:	14

Search results (UniProt accession: O14672)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014234	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014265	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome