DAR - Bologna Biocomputing Group

Search summary (UniProt accession: O00329)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	9
Number of reactions:	17

Search results (UniProt accession: O00329)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013226	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome
MONDO:0014222	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome
MONDO:0023655	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome