DAR - Bologna Biocomputing Group

Search summary (EC number: 4.6.1.2)

Number of enzymes:	4
Number of disease:	15
Number of reactomes:	5
Number of reactions:	5

Search results (EC number: 4.6.1.2)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000455	GUCY2D	Q02846	4.6.1.2	R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome	Sensory Perception	R-HSA-74885 ( R-HSA-2514859 ) R-HSA-74885 Reaction Name: GUCYs converts GTP to cGMP See in Reactome
MONDO:0008764	GUCY2D	Q02846	4.6.1.2	R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome	Sensory Perception	R-HSA-74885 ( R-HSA-2514859 ) R-HSA-74885 Reaction Name: GUCYs converts GTP to cGMP See in Reactome
MONDO:0009126	GUCY2C	P25092	4.6.1.2	R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome	Digestion and absorption	R-HSA-8936214 ( R-HSA-8935690 ) R-HSA-8936214 Reaction Name: GUCY2C trimer binds GUCA2A,B See in Reactome
MONDO:0009649	GUCY1A1	Q02108	4.6.1.2	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-392143 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392143 Reaction Name: NO binds to Guanylate Cyclase See in Reactome R-HSA-392152 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392152 Reaction Name: Soluble guanylate cyclase converts GTP to cGMP See in Reactome
MONDO:0011143	GUCY2D	Q02846	4.6.1.2	R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome	Sensory Perception	R-HSA-74885 ( R-HSA-2514859 ) R-HSA-74885 Reaction Name: GUCYs converts GTP to cGMP See in Reactome
MONDO:0011275	NPR2	P20594	4.6.1.2	R-HSA-5578768 R-HSA-5578768 Reactome Name: Physiological factors See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome	Muscle contraction	R-HSA-5692408 ( R-HSA-5578768 ) R-HSA-5692408 Reaction Name: NPR2 binds NPPC See in Reactome
MONDO:0013825	GUCY2C	P25092	4.6.1.2	R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome	Digestion and absorption	R-HSA-8936214 ( R-HSA-8935690 ) R-HSA-8936214 Reaction Name: GUCY2C trimer binds GUCA2A,B See in Reactome
MONDO:0013843	GUCY2C	P25092	4.6.1.2	R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome	Digestion and absorption	R-HSA-8936214 ( R-HSA-8935690 ) R-HSA-8936214 Reaction Name: GUCY2C trimer binds GUCA2A,B See in Reactome
MONDO:0014331	GUCY1A1	Q02108	4.6.1.2	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-392143 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392143 Reaction Name: NO binds to Guanylate Cyclase See in Reactome R-HSA-392152 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392152 Reaction Name: Soluble guanylate cyclase converts GTP to cGMP See in Reactome
MONDO:0014401	NPR2	P20594	4.6.1.2	R-HSA-5578768 R-HSA-5578768 Reactome Name: Physiological factors See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome	Muscle contraction	R-HSA-5692408 ( R-HSA-5578768 ) R-HSA-5692408 Reaction Name: NPR2 binds NPPC See in Reactome
MONDO:0014551	NPR2	P20594	4.6.1.2	R-HSA-5578768 R-HSA-5578768 Reactome Name: Physiological factors See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome	Muscle contraction	R-HSA-5692408 ( R-HSA-5578768 ) R-HSA-5692408 Reaction Name: NPR2 binds NPPC See in Reactome
MONDO:0015170	GUCY2C	P25092	4.6.1.2	R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome	Digestion and absorption	R-HSA-8936214 ( R-HSA-8935690 ) R-HSA-8936214 Reaction Name: GUCY2C trimer binds GUCA2A,B See in Reactome
MONDO:0015469	NPR2	P20594	4.6.1.2	R-HSA-5578768 R-HSA-5578768 Reactome Name: Physiological factors See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome	Muscle contraction	R-HSA-5692408 ( R-HSA-5578768 ) R-HSA-5692408 Reaction Name: NPR2 binds NPPC See in Reactome
MONDO:0024539	GUCY2D	Q02846	4.6.1.2	R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome	Sensory Perception	R-HSA-74885 ( R-HSA-2514859 ) R-HSA-74885 Reaction Name: GUCYs converts GTP to cGMP See in Reactome
MONDO:0032811	GUCY2D	Q02846	4.6.1.2	R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome	Sensory Perception	R-HSA-74885 ( R-HSA-2514859 ) R-HSA-74885 Reaction Name: GUCYs converts GTP to cGMP See in Reactome