DAR - Bologna Biocomputing Group

Search summary (EC number: 4.6.1.1)

Number of enzymes:	5
Number of disease:	7
Number of reactomes:	14
Number of reactions:	22

Search results (EC number: 4.6.1.1)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001595	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0007748	ADCY10	Q96PN6	4.6.1.1	R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome	Signal Transduction	R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0011707	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0012421	ADCY1	Q08828	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-442715 ( R-HSA-442720 ) R-HSA-442715 Reaction Name: Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome R-HSA-9617535 ( R-HSA-442720 ) R-HSA-9617535 Reaction Name: Activated calmodulin binds ADCY1,ADCY8 See in Reactome
MONDO:0014570	ADCY6	O43306	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0019182	ADCY3	O60266	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-381753 R-HSA-381753 Reactome Name: Olfactory Signaling Pathway See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Sensory Perception Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome R-HSA-9712183 ( R-HSA-381753 ) R-HSA-9712183 Reaction Name: ADCY3:GNAL:GTP converts ATP to cAMP See in Reactome R-HSA-9712187 ( R-HSA-381753 ) R-HSA-9712187 Reaction Name: GNAL:GTP (G alpha-olf) binds ADCY3 See in Reactome
OMIM:619647	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome