DAR - Bologna Biocomputing Group

Search summary (EC number: 4.2.1.17)

Number of enzymes:	3
Number of disease:	6
Number of reactomes:	12
Number of reactions:	24

Search results (EC number: 4.2.1.17)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009855	EHHADH	Q08426	5.3.3.8 1.1.1.35 4.2.1.17	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Metabolism Protein localization	R-HSA-6809263 ( R-HSA-390247 ) R-HSA-6809263 Reaction Name: EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-6809264 ( R-HSA-390247 ) R-HSA-6809264 Reaction Name: EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0012172	HADHA	P40939	2.3.1.- 1.1.1.211 4.2.1.17	R-HSA-77288 R-HSA-77288 Reactome Name: mitochondrial fatty acid beta-oxidation of unsaturated fatty acids See in Reactome R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77285 R-HSA-77285 Reactome Name: Beta oxidation of myristoyl-CoA to lauroyl-CoA See in Reactome R-HSA-77305 R-HSA-77305 Reactome Name: Beta oxidation of palmitoyl-CoA to myristoyl-CoA See in Reactome R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-109339 ( R-HSA-77288 ) R-HSA-109339 Reaction Name: Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation See in Reactome R-HSA-109342 ( R-HSA-77288 ) R-HSA-109342 Reaction Name: Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation See in Reactome R-HSA-1482775 ( R-HSA-1482798 ) R-HSA-1482775 Reaction Name: MLCL is acylated to CL by HADH (IM) See in Reactome R-HSA-77271 ( R-HSA-77285 ) R-HSA-77271 Reaction Name: 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA See in Reactome R-HSA-77277 ( R-HSA-77285 ) R-HSA-77277 Reaction Name: trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA See in Reactome R-HSA-77283 ( R-HSA-77285 ) R-HSA-77283 Reaction Name: (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H See in Reactome R-HSA-77301 ( R-HSA-77305 ) R-HSA-77301 Reaction Name: trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA See in Reactome R-HSA-77303 ( R-HSA-77305 ) R-HSA-77303 Reaction Name: (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H See in Reactome R-HSA-77304 ( R-HSA-77305 ) R-HSA-77304 Reaction Name: 3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA See in Reactome R-HSA-77309 ( R-HSA-77310 ) R-HSA-77309 Reaction Name: 3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA See in Reactome R-HSA-77321 ( R-HSA-77350 ) R-HSA-77321 Reaction Name: 3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA See in Reactome R-HSA-77329 ( R-HSA-77348 ) R-HSA-77329 Reaction Name: 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA See in Reactome R-HSA-77340 ( R-HSA-77346 ) R-HSA-77340 Reaction Name: 3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA See in Reactome
MONDO:0012173	HADHA	P40939	2.3.1.- 1.1.1.211 4.2.1.17	R-HSA-77288 R-HSA-77288 Reactome Name: mitochondrial fatty acid beta-oxidation of unsaturated fatty acids See in Reactome R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77285 R-HSA-77285 Reactome Name: Beta oxidation of myristoyl-CoA to lauroyl-CoA See in Reactome R-HSA-77305 R-HSA-77305 Reactome Name: Beta oxidation of palmitoyl-CoA to myristoyl-CoA See in Reactome R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-109339 ( R-HSA-77288 ) R-HSA-109339 Reaction Name: Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation See in Reactome R-HSA-109342 ( R-HSA-77288 ) R-HSA-109342 Reaction Name: Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation See in Reactome R-HSA-1482775 ( R-HSA-1482798 ) R-HSA-1482775 Reaction Name: MLCL is acylated to CL by HADH (IM) See in Reactome R-HSA-77271 ( R-HSA-77285 ) R-HSA-77271 Reaction Name: 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA See in Reactome R-HSA-77277 ( R-HSA-77285 ) R-HSA-77277 Reaction Name: trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA See in Reactome R-HSA-77283 ( R-HSA-77285 ) R-HSA-77283 Reaction Name: (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H See in Reactome R-HSA-77301 ( R-HSA-77305 ) R-HSA-77301 Reaction Name: trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA See in Reactome R-HSA-77303 ( R-HSA-77305 ) R-HSA-77303 Reaction Name: (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H See in Reactome R-HSA-77304 ( R-HSA-77305 ) R-HSA-77304 Reaction Name: 3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA See in Reactome R-HSA-77309 ( R-HSA-77310 ) R-HSA-77309 Reaction Name: 3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA See in Reactome R-HSA-77321 ( R-HSA-77350 ) R-HSA-77321 Reaction Name: 3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA See in Reactome R-HSA-77329 ( R-HSA-77348 ) R-HSA-77329 Reaction Name: 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA See in Reactome R-HSA-77340 ( R-HSA-77346 ) R-HSA-77340 Reaction Name: 3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA See in Reactome
MONDO:0014275	EHHADH	Q08426	5.3.3.8 1.1.1.35 4.2.1.17	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Metabolism Protein localization	R-HSA-6809263 ( R-HSA-390247 ) R-HSA-6809263 Reaction Name: EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-6809264 ( R-HSA-390247 ) R-HSA-6809264 Reaction Name: EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0014563	ECHS1	P30084	5.3.3.8 4.2.1.17	R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77352 R-HSA-77352 Reactome Name: Beta oxidation of butanoyl-CoA to acetyl-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-70870 ( R-HSA-70895 ) R-HSA-70870 Reaction Name: ECHS1 hydrates methacrylyl-CoA See in Reactome R-HSA-77256 ( R-HSA-77310 ) R-HSA-77256 Reaction Name: 2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA See in Reactome R-HSA-77314 ( R-HSA-77352 ) R-HSA-77314 Reaction Name: Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA See in Reactome R-HSA-77325 ( R-HSA-77350 ) R-HSA-77325 Reaction Name: trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA See in Reactome R-HSA-77333 ( R-HSA-77348 ) R-HSA-77333 Reaction Name: trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA See in Reactome R-HSA-77344 ( R-HSA-77346 ) R-HSA-77344 Reaction Name: trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA See in Reactome
MONDO:0016573	HADHA	P40939	2.3.1.- 1.1.1.211 4.2.1.17	R-HSA-77288 R-HSA-77288 Reactome Name: mitochondrial fatty acid beta-oxidation of unsaturated fatty acids See in Reactome R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77285 R-HSA-77285 Reactome Name: Beta oxidation of myristoyl-CoA to lauroyl-CoA See in Reactome R-HSA-77305 R-HSA-77305 Reactome Name: Beta oxidation of palmitoyl-CoA to myristoyl-CoA See in Reactome R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-109339 ( R-HSA-77288 ) R-HSA-109339 Reaction Name: Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation See in Reactome R-HSA-109342 ( R-HSA-77288 ) R-HSA-109342 Reaction Name: Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation See in Reactome R-HSA-1482775 ( R-HSA-1482798 ) R-HSA-1482775 Reaction Name: MLCL is acylated to CL by HADH (IM) See in Reactome R-HSA-77271 ( R-HSA-77285 ) R-HSA-77271 Reaction Name: 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA See in Reactome R-HSA-77277 ( R-HSA-77285 ) R-HSA-77277 Reaction Name: trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA See in Reactome R-HSA-77283 ( R-HSA-77285 ) R-HSA-77283 Reaction Name: (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H See in Reactome R-HSA-77301 ( R-HSA-77305 ) R-HSA-77301 Reaction Name: trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA See in Reactome R-HSA-77303 ( R-HSA-77305 ) R-HSA-77303 Reaction Name: (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H See in Reactome R-HSA-77304 ( R-HSA-77305 ) R-HSA-77304 Reaction Name: 3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA See in Reactome R-HSA-77309 ( R-HSA-77310 ) R-HSA-77309 Reaction Name: 3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA See in Reactome R-HSA-77321 ( R-HSA-77350 ) R-HSA-77321 Reaction Name: 3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA See in Reactome R-HSA-77329 ( R-HSA-77348 ) R-HSA-77329 Reaction Name: 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA See in Reactome R-HSA-77340 ( R-HSA-77346 ) R-HSA-77340 Reaction Name: 3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA See in Reactome