DAR - Bologna Biocomputing Group

Search summary (EC number: 4.2.1.152)

Number of enzymes:	4
Number of disease:	8
Number of reactomes:	11
Number of reactions:	13

Search results (EC number: 4.2.1.152)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007664	CYP1B1	Q16678	4.2.1.152 1.14.14.1	R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211951 ( R-HSA-211976 ) R-HSA-211951 Reaction Name: CYP1B1 4-hydroxylates EST17b See in Reactome R-HSA-2161795 ( R-HSA-2142816 ) R-HSA-2161795 Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161890 ( R-HSA-2142670 ) R-HSA-2161890 Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome
MONDO:0007781	PTGIS	Q16647	4.2.1.152 5.3.99.4	R-HSA-197264 R-HSA-197264 Reactome Name: Nicotinamide salvaging See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-211994 R-HSA-211994 Reactome Name: Sterols are 12-hydroxylated by CYP8B1 See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome	R-HSA-196807 R-HSA-196807 Reactome Name: Nicotinate metabolism See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192157 ( R-HSA-193368; R-HSA-211976; R-HSA-211994 ) R-HSA-192157 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7aOLONE See in Reactome R-HSA-193709 ( R-HSA-193775; R-HSA-211976; R-HSA-211994 ) R-HSA-193709 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL See in Reactome R-HSA-193845 ( R-HSA-193807; R-HSA-211976; R-HSA-211994 ) R-HSA-193845 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,27DONE See in Reactome R-HSA-76496 ( R-HSA-197264; R-HSA-211979; R-HSA-2162123 ) R-HSA-76496 Reaction Name: PTGIS, CYP8A1 isomerise PGH2 to PGI2 See in Reactome
MONDO:0009274	TBXAS1	P24557	4.2.1.152 5.3.99.5	R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-2161613 ( R-HSA-2162123 ) R-HSA-2161613 Reaction Name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 See in Reactome R-HSA-76500 ( R-HSA-211979; R-HSA-2162123 ) R-HSA-76500 Reaction Name: TBXAS1 isomerises PGH2 to TXA2 See in Reactome
MONDO:0009277	CYP1B1	Q16678	4.2.1.152 1.14.14.1	R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211951 ( R-HSA-211976 ) R-HSA-211951 Reaction Name: CYP1B1 4-hydroxylates EST17b See in Reactome R-HSA-2161795 ( R-HSA-2142816 ) R-HSA-2161795 Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161890 ( R-HSA-2142670 ) R-HSA-2161890 Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome
MONDO:0010968	CYP1B1	Q16678	4.2.1.152 1.14.14.1	R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211951 ( R-HSA-211976 ) R-HSA-211951 Reaction Name: CYP1B1 4-hydroxylates EST17b See in Reactome R-HSA-2161795 ( R-HSA-2142816 ) R-HSA-2161795 Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161890 ( R-HSA-2142670 ) R-HSA-2161890 Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome
MONDO:0011414	CYP1B1	Q16678	4.2.1.152 1.14.14.1	R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211951 ( R-HSA-211976 ) R-HSA-211951 Reaction Name: CYP1B1 4-hydroxylates EST17b See in Reactome R-HSA-2161795 ( R-HSA-2142816 ) R-HSA-2161795 Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161890 ( R-HSA-2142670 ) R-HSA-2161890 Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome
MONDO:0011680	ALOXE3	Q9BYJ1	5.4.4.7 4.2.1.152	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8942208 ( R-HSA-2142712 ) R-HSA-8942208 Reaction Name: ALOXE3 isomerises 12R-HpETE to HXA3 See in Reactome
MONDO:0015016	CYP1B1	Q16678	4.2.1.152 1.14.14.1	R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211951 ( R-HSA-211976 ) R-HSA-211951 Reaction Name: CYP1B1 4-hydroxylates EST17b See in Reactome R-HSA-2161795 ( R-HSA-2142816 ) R-HSA-2161795 Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161890 ( R-HSA-2142670 ) R-HSA-2161890 Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome