MONDO:0007664 |
CYP1B1 |
Q16678 |
4.2.1.152
1.14.14.1
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211976
R-HSA-2142670
R-HSA-2142670
Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211951
(
R-HSA-211976
)
R-HSA-2161795
(
R-HSA-2142816
)
R-HSA-2161795
Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
See in Reactome
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161890
(
R-HSA-2142670
)
R-HSA-2161890
Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
See in Reactome
R-HSA-2161899
(
R-HSA-2142670
)
R-HSA-2161899
Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|
MONDO:0007781 |
PTGIS |
Q16647 |
4.2.1.152
5.3.99.4
|
R-HSA-197264
R-HSA-193807
R-HSA-193807
Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
See in Reactome
R-HSA-211994
R-HSA-211994
Reactome Name: Sterols are 12-hydroxylated by CYP8B1
See in Reactome
R-HSA-193368
R-HSA-193368
Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
See in Reactome
R-HSA-193775
R-HSA-193775
Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
See in Reactome
R-HSA-2162123
R-HSA-2162123
Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
See in Reactome
R-HSA-211979
|
R-HSA-196807
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-194068
R-HSA-194068
Reactome Name: Bile acid and bile salt metabolism
See in Reactome
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-211976
R-HSA-8978868
R-HSA-192105
R-HSA-192105
Reactome Name: Synthesis of bile acids and bile salts
See in Reactome
R-HSA-2142753
R-HSA-556833
R-HSA-1430728
R-HSA-196849
R-HSA-196849
Reactome Name: Metabolism of water-soluble vitamins and cofactors
See in Reactome
R-HSA-8957322
|
Metabolism
|
R-HSA-192157
(
R-HSA-193368;
R-HSA-211976;
R-HSA-211994
)
R-HSA-192157
Reaction Name: CYP8B1 12-hydroxylates 4CHOL7aOLONE
See in Reactome
R-HSA-193709
(
R-HSA-193775;
R-HSA-211976;
R-HSA-211994
)
R-HSA-193709
Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL
See in Reactome
R-HSA-193845
(
R-HSA-193807;
R-HSA-211976;
R-HSA-211994
)
R-HSA-193845
Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,27DONE
See in Reactome
R-HSA-76496
(
R-HSA-197264;
R-HSA-211979;
R-HSA-2162123
)
R-HSA-76496
Reaction Name: PTGIS, CYP8A1 isomerise PGH2 to PGI2
See in Reactome
|
MONDO:0009274 |
TBXAS1 |
P24557 |
4.2.1.152
5.3.99.5
|
R-HSA-211979
R-HSA-2162123
R-HSA-2162123
Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-2161613
(
R-HSA-2162123
)
R-HSA-2161613
Reaction Name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1
See in Reactome
R-HSA-76500
(
R-HSA-211979;
R-HSA-2162123
)
|
MONDO:0009277 |
MONDO:0009277
Disease Name: glaucoma 3A
OMIM id: OMIM:231300
Orphanet id: Orphanet:98977
All associated enzymes in DAR:
CYP1B1
. The disease is also associated to other non-enzyme proteins (not in DAR).
CYP1B1 |
Q16678 |
4.2.1.152
1.14.14.1
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211976
R-HSA-2142670
R-HSA-2142670
Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211951
(
R-HSA-211976
)
R-HSA-2161795
(
R-HSA-2142816
)
R-HSA-2161795
Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
See in Reactome
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161890
(
R-HSA-2142670
)
R-HSA-2161890
Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
See in Reactome
R-HSA-2161899
(
R-HSA-2142670
)
R-HSA-2161899
Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|
MONDO:0010968 |
CYP1B1 |
Q16678 |
4.2.1.152
1.14.14.1
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211976
R-HSA-2142670
R-HSA-2142670
Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211951
(
R-HSA-211976
)
R-HSA-2161795
(
R-HSA-2142816
)
R-HSA-2161795
Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
See in Reactome
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161890
(
R-HSA-2142670
)
R-HSA-2161890
Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
See in Reactome
R-HSA-2161899
(
R-HSA-2142670
)
R-HSA-2161899
Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|
MONDO:0011414 |
MONDO:0011414
Disease Name: Peters anomaly
OMIM id: OMIM:612968
Orphanet id: Orphanet:708
All associated enzymes in DAR:
CYP1B1
. The disease is also associated to other non-enzyme proteins (not in DAR).
CYP1B1 |
Q16678 |
4.2.1.152
1.14.14.1
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211976
R-HSA-2142670
R-HSA-2142670
Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211951
(
R-HSA-211976
)
R-HSA-2161795
(
R-HSA-2142816
)
R-HSA-2161795
Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
See in Reactome
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161890
(
R-HSA-2142670
)
R-HSA-2161890
Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
See in Reactome
R-HSA-2161899
(
R-HSA-2142670
)
R-HSA-2161899
Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|
MONDO:0011680 |
ALOXE3 |
Q9BYJ1 |
5.4.4.7
4.2.1.152
|
R-HSA-2142712
R-HSA-2142712
Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
|
Metabolism
|
R-HSA-8942208
(
R-HSA-2142712
)
R-HSA-8942208
Reaction Name: ALOXE3 isomerises 12R-HpETE to HXA3
See in Reactome
|
MONDO:0015016 |
CYP1B1 |
Q16678 |
4.2.1.152
1.14.14.1
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211976
R-HSA-2142670
R-HSA-2142670
Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211951
(
R-HSA-211976
)
R-HSA-2161795
(
R-HSA-2142816
)
R-HSA-2161795
Reaction Name: Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
See in Reactome
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161890
(
R-HSA-2142670
)
R-HSA-2161890
Reaction Name: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
See in Reactome
R-HSA-2161899
(
R-HSA-2142670
)
R-HSA-2161899
Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|