DAR - Bologna Biocomputing Group

Search results (EC number: 3.6.4.13)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	DHX16	O60231	3.6.4.13	R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome	Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome
MONDO:0001071	DHX34	Q14147	3.6.4.13
MONDO:0001071	DHX30	Q7L2E3	3.6.4.13
MONDO:0001071	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome
MONDO:0001071	DDX54	Q8TDD1	3.6.4.13
MONDO:0001149	DHX34	Q14147	3.6.4.13
MONDO:0005260	DHX30	Q7L2E3	3.6.4.13
MONDO:0006033	BRIP1	Q9BX63	3.6.4.13	R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) DNA Repair Metabolism Cell Cycle	R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome
MONDO:0007354	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome
MONDO:0007774	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0008267	DDX59	Q5T1V6	3.6.4.13
MONDO:0008939	DDX3X	O00571	3.6.4.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0009021	DDX3X	O00571	3.6.4.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0009022	DHX16	O60231	3.6.4.13	R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome	Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome
MONDO:0009998	EIF4A3	P38919	3.6.4.13	R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-975957 R-HSA-975957 Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome R-HSA-159236 R-HSA-159236 Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-72187 R-HSA-72187 Reactome Name: mRNA 3'-end processing See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-73856 R-HSA-73856 Reactome Name: RNA Polymerase II Transcription Termination See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-72202 R-HSA-72202 Reactome Name: Transport of Mature Transcript to Cytoplasm See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-927802 R-HSA-927802 Reactome Name: Nonsense-Mediated Decay (NMD) See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Immune System Developmental Biology	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-159101 ( R-HSA-159236 ) R-HSA-159101 Reaction Name: NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) See in Reactome R-HSA-1678842 ( R-HSA-1169408 ) R-HSA-1678842 Reaction Name: Competitive inhibition of translation initiation by ISGylated 4EHP See in Reactome R-HSA-429955 ( R-HSA-429947 ) R-HSA-429955 Reaction Name: CCR4-NOT complex deadenylates mRNA See in Reactome R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-430021 ( R-HSA-429947 ) R-HSA-430021 Reaction Name: PAN2-PAN3 complex partially deadenylates mRNA See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-72180 ( R-HSA-72187; R-HSA-73856 ) R-HSA-72180 Reaction Name: Cleavage of mRNA at the 3'-end See in Reactome R-HSA-72185 ( R-HSA-72187 ) R-HSA-72185 Reaction Name: mRNA polyadenylation See in Reactome R-HSA-75096 ( R-HSA-159236 ) R-HSA-75096 Reaction Name: Docking of the TAP:EJC Complex with the NPC See in Reactome R-HSA-75097 ( R-HSA-159236 ) R-HSA-75097 Reaction Name: Transport of the export-competent mRNP complex through the NPC See in Reactome R-HSA-75098 ( R-HSA-159236 ) R-HSA-75098 Reaction Name: mRNP complex dissociates from cytosolic face of NPC See in Reactome R-HSA-8849157 ( R-HSA-72187 ) R-HSA-8849157 Reaction Name: TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally See in Reactome R-HSA-8941312 ( R-HSA-429947 ) R-HSA-8941312 Reaction Name: ZCCHC6, ZCCHC11 are mRNA uridyltransferases See in Reactome R-HSA-9014610 ( R-HSA-9010553 ) R-HSA-9014610 Reaction Name: Translation of ROBO3.2 mRNA initiates NMD See in Reactome R-HSA-9014652 ( R-HSA-9010553 ) R-HSA-9014652 Reaction Name: Translation of ROBO3.2 mRNA is negatively regulated by NMD See in Reactome R-HSA-927813 ( R-HSA-975957 ) R-HSA-927813 Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A See in Reactome R-HSA-927832 ( R-HSA-975957 ) R-HSA-927832 Reaction Name: UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex See in Reactome R-HSA-927836 ( R-HSA-975957 ) R-HSA-927836 Reaction Name: SMG6 hydrolyzes mRNA with premature termination codon See in Reactome R-HSA-927889 ( R-HSA-975957 ) R-HSA-927889 Reaction Name: SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) See in Reactome
MONDO:0010107	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome
MONDO:0010497	DDX3X	O00571	3.6.4.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0011436	IGHMBP2	P38935	3.6.4.12 3.6.4.13
MONDO:0012187	BRIP1	Q9BX63	3.6.4.13	R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) DNA Repair Metabolism Cell Cycle	R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome
MONDO:0012422	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0012477	SNRNP200	O75643	3.6.4.13	R-HSA-72165 R-HSA-72165 Reactome Name: mRNA Splicing - Minor Pathway See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome	Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-72127 ( R-HSA-72163 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-75079 ( R-HSA-72165 ) R-HSA-75079 Reaction Name: Formation of AT-AC C complex See in Reactome R-HSA-75081 ( R-HSA-72165 ) R-HSA-75081 Reaction Name: Formation of AT-AC B Complex See in Reactome R-HSA-75082 ( R-HSA-72165 ) R-HSA-75082 Reaction Name: ATAC spliceosome mediated Lariat formation,5' splice site cleavage See in Reactome R-HSA-75083 ( R-HSA-72165 ) R-HSA-75083 Reaction Name: ATAC spliceosome mediated 3' splice site cleavage, exon ligation See in Reactome
MONDO:0014367	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014511	IGHMBP2	P38935	3.6.4.12 3.6.4.13
MONDO:0014575	DDX58	O95786	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System Metabolism of proteins	R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-168935 ( R-HSA-168928 ) R-HSA-168935 Reaction Name: viral dsRNA binds DDX58 See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5696564 ( R-HSA-5689880 ) R-HSA-5696564 Reaction Name: USP25 deubiquitinates DDX58 See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-8985153 ( R-HSA-8983711 ) R-HSA-8985153 Reaction Name: OASL binds DDX58 See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936390 ( R-HSA-168928; R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-936563 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936563 Reaction Name: ISGylation of DDX58 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014809	DDX41	Q9UJV9	3.6.4.13	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3134822 ( R-HSA-1834941 ) R-HSA-3134822 Reaction Name: DDX41 binds viral dsDNA See in Reactome R-HSA-3134946 ( R-HSA-3134975 ) R-HSA-3134946 Reaction Name: DDX41 ubiquitination by TRIM21 See in Reactome R-HSA-9013869 ( R-HSA-1834941 ) R-HSA-9013869 Reaction Name: DDX41 binds bacterial c-di-AMP, c-di-GMP See in Reactome
MONDO:0015362	IGHMBP2	P38935	3.6.4.12 3.6.4.13
MONDO:0016392	DDX3X	O00571	3.6.4.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0016419	BRIP1	Q9BX63	3.6.4.13	R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) DNA Repair Metabolism Cell Cycle	R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome
MONDO:0016674	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome
MONDO:0018393	FANCM	Q8IYD8	3.6.4.13	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785087 ( R-HSA-6783310 ) R-HSA-6785087 Reaction Name: FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA See in Reactome R-HSA-6785126 ( R-HSA-6783310 ) R-HSA-6785126 Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs) See in Reactome R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6785607 ( R-HSA-6783310 ) R-HSA-6785607 Reaction Name: FANCM binds FAAP24 See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome R-HSA-6786155 ( R-HSA-6783310 ) R-HSA-6786155 Reaction Name: POLN binds ICL-DNA See in Reactome R-HSA-6786166 ( R-HSA-6783310 ) R-HSA-6786166 Reaction Name: Translesion synthesis across unhooked ICL by POLN See in Reactome R-HSA-6786171 ( R-HSA-6783310 ) R-HSA-6786171 Reaction Name: FANCD2 deubiquitination by USP1:WDR48 See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome
MONDO:0018393	TDRD9	Q8NDG6	3.6.4.13	R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome	Gene expression (Transcription)	R-HSA-5601883 ( R-HSA-5601884 ) R-HSA-5601883 Reaction Name: Complexed PIWIL4 binds cleaved transposon RNA See in Reactome R-HSA-5601897 ( R-HSA-5601884 ) R-HSA-5601897 Reaction Name: MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events See in Reactome R-HSA-5601919 ( R-HSA-5601884 ) R-HSA-5601919 Reaction Name: Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH See in Reactome R-HSA-5629237 ( R-HSA-5601884 ) R-HSA-5629237 Reaction Name: HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH See in Reactome
MONDO:0018709	DDX3X	O00571	3.6.4.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0019391	FANCM	Q8IYD8	3.6.4.13	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785087 ( R-HSA-6783310 ) R-HSA-6785087 Reaction Name: FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA See in Reactome R-HSA-6785126 ( R-HSA-6783310 ) R-HSA-6785126 Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs) See in Reactome R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6785607 ( R-HSA-6783310 ) R-HSA-6785607 Reaction Name: FANCM binds FAAP24 See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome R-HSA-6786155 ( R-HSA-6783310 ) R-HSA-6786155 Reaction Name: POLN binds ICL-DNA See in Reactome R-HSA-6786166 ( R-HSA-6783310 ) R-HSA-6786166 Reaction Name: Translesion synthesis across unhooked ICL by POLN See in Reactome R-HSA-6786171 ( R-HSA-6783310 ) R-HSA-6786171 Reaction Name: FANCD2 deubiquitination by USP1:WDR48 See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome
MONDO:0019636	DHX34	Q14147	3.6.4.13
MONDO:0019637	DDX54	Q8TDD1	3.6.4.13
MONDO:0020851	TDRD9	Q8NDG6	3.6.4.13	R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome	Gene expression (Transcription)	R-HSA-5601883 ( R-HSA-5601884 ) R-HSA-5601883 Reaction Name: Complexed PIWIL4 binds cleaved transposon RNA See in Reactome R-HSA-5601897 ( R-HSA-5601884 ) R-HSA-5601897 Reaction Name: MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events See in Reactome R-HSA-5601919 ( R-HSA-5601884 ) R-HSA-5601919 Reaction Name: Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH See in Reactome R-HSA-5629237 ( R-HSA-5601884 ) R-HSA-5629237 Reaction Name: HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH See in Reactome
MONDO:0024535	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0032604	DHX38	Q92620	3.6.4.13	R-HSA-72187 R-HSA-72187 Reactome Name: mRNA 3'-end processing See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-73856 R-HSA-73856 Reactome Name: RNA Polymerase II Transcription Termination See in Reactome R-HSA-159236 R-HSA-159236 Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript See in Reactome	R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72202 R-HSA-72202 Reactome Name: Transport of Mature Transcript to Cytoplasm See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-159101 ( R-HSA-159236 ) R-HSA-159101 Reaction Name: NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) See in Reactome R-HSA-72124 ( R-HSA-72163 ) R-HSA-72124 Reaction Name: Formation of the Spliceosomal A Complex See in Reactome R-HSA-72127 ( R-HSA-72163 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-72180 ( R-HSA-72187; R-HSA-73856 ) R-HSA-72180 Reaction Name: Cleavage of mRNA at the 3'-end See in Reactome R-HSA-72185 ( R-HSA-72187 ) R-HSA-72185 Reaction Name: mRNA polyadenylation See in Reactome R-HSA-75096 ( R-HSA-159236 ) R-HSA-75096 Reaction Name: Docking of the TAP:EJC Complex with the NPC See in Reactome R-HSA-8849157 ( R-HSA-72187 ) R-HSA-8849157 Reaction Name: TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally See in Reactome
MONDO:0032851	DDX6	P26196	3.6.4.13	R-HSA-430039 R-HSA-430039 Reactome Name: mRNA decay by 5' to 3' exoribonuclease See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Metabolism of RNA	R-HSA-429860 ( R-HSA-430039 ) R-HSA-429860 Reaction Name: DCP1-DCP2 complex decaps mRNA See in Reactome
MONDO:0032888	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome
MONDO:0032890	DHX16	O60231	3.6.4.13	R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome	Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome
MONDO:0054732	FANCM	Q8IYD8	3.6.4.13	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785087 ( R-HSA-6783310 ) R-HSA-6785087 Reaction Name: FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA See in Reactome R-HSA-6785126 ( R-HSA-6783310 ) R-HSA-6785126 Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs) See in Reactome R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6785607 ( R-HSA-6783310 ) R-HSA-6785607 Reaction Name: FANCM binds FAAP24 See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome R-HSA-6786155 ( R-HSA-6783310 ) R-HSA-6786155 Reaction Name: POLN binds ICL-DNA See in Reactome R-HSA-6786166 ( R-HSA-6783310 ) R-HSA-6786166 Reaction Name: Translesion synthesis across unhooked ICL by POLN See in Reactome R-HSA-6786171 ( R-HSA-6783310 ) R-HSA-6786171 Reaction Name: FANCD2 deubiquitination by USP1:WDR48 See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome
MONDO:0054862	FANCM	Q8IYD8	3.6.4.13	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785087 ( R-HSA-6783310 ) R-HSA-6785087 Reaction Name: FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA See in Reactome R-HSA-6785126 ( R-HSA-6783310 ) R-HSA-6785126 Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs) See in Reactome R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6785607 ( R-HSA-6783310 ) R-HSA-6785607 Reaction Name: FANCM binds FAAP24 See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome R-HSA-6786155 ( R-HSA-6783310 ) R-HSA-6786155 Reaction Name: POLN binds ICL-DNA See in Reactome R-HSA-6786166 ( R-HSA-6783310 ) R-HSA-6786166 Reaction Name: Translesion synthesis across unhooked ICL by POLN See in Reactome R-HSA-6786171 ( R-HSA-6783310 ) R-HSA-6786171 Reaction Name: FANCD2 deubiquitination by USP1:WDR48 See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome
MONDO:0060596	DDX6	P26196	3.6.4.13	R-HSA-430039 R-HSA-430039 Reactome Name: mRNA decay by 5' to 3' exoribonuclease See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Metabolism of RNA	R-HSA-429860 ( R-HSA-430039 ) R-HSA-429860 Reaction Name: DCP1-DCP2 complex decaps mRNA See in Reactome
MONDO:0060622	DHX30	Q7L2E3	3.6.4.13
MONDO:8000015	DHX37	Q8IY37	3.6.4.13	R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-6790901 R-HSA-6790901 Reactome Name: rRNA modification in the nucleus and cytosol See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6790906 ( R-HSA-6790901 ) R-HSA-6790906 Reaction Name: EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 See in Reactome R-HSA-6791221 ( R-HSA-6791226 ) R-HSA-6791221 Reaction Name: 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA See in Reactome R-HSA-6791222 ( R-HSA-6791226 ) R-HSA-6791222 Reaction Name: 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA See in Reactome R-HSA-6791227 ( R-HSA-6791226 ) R-HSA-6791227 Reaction Name: 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA See in Reactome R-HSA-6791228 ( R-HSA-6791226 ) R-HSA-6791228 Reaction Name: 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA See in Reactome

Number of enzymes:	18
Number of disease:	41
Number of reactomes:	37
Number of reactions:	122

Search summary (EC number: 3.6.4.13)

Search results (EC number: 3.6.4.13)

MONDO:0001071

R-HSA-72163

R-HSA-8953854

R-HSA-72203

R-HSA-72172

R-HSA-156661

R-HSA-72130

R-HSA-72139

R-HSA-72143

R-HSA-72160

MONDO:0001071

MONDO:0001071

MONDO:0001071

R-HSA-6791226

R-HSA-6790901

R-HSA-8953854

R-HSA-8868773

R-HSA-72312

R-HSA-6790906

R-HSA-6791221

R-HSA-6791222

R-HSA-6791227

R-HSA-6791228

MONDO:0001071

MONDO:0001149

MONDO:0005260

MONDO:0006033

R-HSA-5693568

R-HSA-2564830

R-HSA-5693554

R-HSA-6804756

R-HSA-5693579

R-HSA-5693607

R-HSA-5685942

R-HSA-5685938

R-HSA-5693616

R-HSA-69473

R-HSA-3700989

R-HSA-5633007

R-HSA-69481

R-HSA-212436

R-HSA-74160

R-HSA-5693567

R-HSA-5693538

R-HSA-69620

R-HSA-73894

R-HSA-1430728

R-HSA-1640170

R-HSA-5693532

R-HSA-5693537

R-HSA-73857

R-HSA-2564828

R-HSA-5684875

R-HSA-5684882

R-HSA-5684887

R-HSA-5685011

R-HSA-5685156

R-HSA-5685341

R-HSA-5685838

R-HSA-5685985

R-HSA-5685994

R-HSA-5686410

R-HSA-5686440

R-HSA-5686469

R-HSA-5686483

R-HSA-5686642

R-HSA-5686657

R-HSA-5693539

R-HSA-5693542

R-HSA-5693561

R-HSA-5693564

R-HSA-5693580

R-HSA-5693584

R-HSA-5693589

R-HSA-5693593

R-HSA-5693620

R-HSA-6799332

MONDO:0007354