DAR - Bologna Biocomputing Group

Search summary (EC number: 3.5.1.98)

Number of enzymes:	3
Number of disease:	4
Number of reactomes:	16
Number of reactions:	33

Search results (EC number: 3.5.1.98)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010463	HDAC6	Q9UBN7	3.5.1.98 3.5.1.-	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9613829 R-HSA-9613829 Reactome Name: Chaperone Mediated Autophagy See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-9615710 R-HSA-9615710 Reactome Name: Late endosomal microautophagy See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Organelle biogenesis and maintenance Cellular responses to stimuli Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5618331 ( R-HSA-5617833 ) R-HSA-5618331 Reaction Name: HDAC6 deacetylates microtubules See in Reactome R-HSA-9008389 ( R-HSA-8878166; R-HSA-8940973 ) R-HSA-9008389 Reaction Name: RUNX2 binds HDAC6 See in Reactome R-HSA-9008433 ( R-HSA-8878166 ) R-HSA-9008433 Reaction Name: RUNX2 binds CDKN1A gene promoter See in Reactome R-HSA-9008456 ( R-HSA-8878166 ) R-HSA-9008456 Reaction Name: CDKN1A gene expression is inhibited by RUNX2 See in Reactome R-HSA-9615721 ( R-HSA-9613829; R-HSA-9615710 ) R-HSA-9615721 Reaction Name: HSPA8 binds substrate See in Reactome R-HSA-9620197 ( R-HSA-9613829 ) R-HSA-9620197 Reaction Name: HSPA8:Substrate binds LAMP2a See in Reactome R-HSA-9622831 ( R-HSA-9613829 ) R-HSA-9622831 Reaction Name: Substrate:LAMP2a binds HSP90 See in Reactome R-HSA-9622840 ( R-HSA-9613829 ) R-HSA-9622840 Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate See in Reactome R-HSA-9624158 ( R-HSA-9613829 ) R-HSA-9624158 Reaction Name: Substrate:LAMP2a:HSP90 polymerizes See in Reactome R-HSA-9625188 ( R-HSA-9613829 ) R-HSA-9625188 Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation See in Reactome R-HSA-9625196 ( R-HSA-9613829 ) R-HSA-9625196 Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8 See in Reactome R-HSA-9625197 ( R-HSA-9613829 ) R-HSA-9625197 Reaction Name: GFAP binds LAMP2a multimer See in Reactome R-HSA-9626060 ( R-HSA-9613829 ) R-HSA-9626060 Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer See in Reactome R-HSA-9631065 ( R-HSA-9615710 ) R-HSA-9631065 Reaction Name: Substrate translocates into late endosomal lumen See in Reactome R-HSA-9631068 ( R-HSA-9615710 ) R-HSA-9631068 Reaction Name: HSPA8:substrate binds late endosomal phospholipids See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646348 ( R-HSA-9646399 ) R-HSA-9646348 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9646383 ( R-HSA-9646399 ) R-HSA-9646383 Reaction Name: Dynein motors transport misfolded proteins See in Reactome R-HSA-9646390 ( R-HSA-9646399 ) R-HSA-9646390 Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule See in Reactome R-HSA-9646679 ( R-HSA-9646399 ) R-HSA-9646679 Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome See in Reactome R-HSA-9646685 ( R-HSA-9646399 ) R-HSA-9646685 Reaction Name: Aggresome dissociates from dynein and microtubule See in Reactome
MONDO:0010471	HDAC8	Q9BY41	3.5.1.98 3.5.1.-	R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Gene expression (Transcription) Chromatin organization Cell Cycle Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-3782637 ( R-HSA-3214815 ) R-HSA-3782637 Reaction Name: HDAC8 deacetylates histones See in Reactome
MONDO:0010665	HDAC8	Q9BY41	3.5.1.98 3.5.1.-	R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Gene expression (Transcription) Chromatin organization Cell Cycle Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-3782637 ( R-HSA-3214815 ) R-HSA-3782637 Reaction Name: HDAC8 deacetylates histones See in Reactome
MONDO:0010886	HDAC4	P56524	3.5.1.98	R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-8941284 R-HSA-8941284 Reactome Name: RUNX2 regulates chondrocyte maturation See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-4615872 ( R-HSA-4551638 ) R-HSA-4615872 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1 See in Reactome R-HSA-4615987 ( R-HSA-4551638 ) R-HSA-4615987 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3 See in Reactome R-HSA-4720432 ( R-HSA-4090294 ) R-HSA-4720432 Reaction Name: HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 See in Reactome R-HSA-4720446 ( R-HSA-4090294 ) R-HSA-4720446 Reaction Name: HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 See in Reactome R-HSA-8952062 ( R-HSA-8951936 ) R-HSA-8952062 Reaction Name: CCND1 recruits HDAC4 to RUNX3 See in Reactome R-HSA-8952069 ( R-HSA-8951936 ) R-HSA-8952069 Reaction Name: HDAC4 deacetylates RUNX3 See in Reactome R-HSA-9008326 ( R-HSA-8878166; R-HSA-8941284 ) R-HSA-9008326 Reaction Name: RUNX2 binds HDAC4 See in Reactome