DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.22.63)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	4
Number of reactions:	7

Search results (EC number: 3.4.22.63)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001056	CASP10	Q92851	3.4.22.63	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-6803207 R-HSA-6803207 Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-141310 ( R-HSA-75157 ) R-HSA-141310 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-141316 ( R-HSA-75158 ) R-HSA-141316 Reaction Name: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-6798139 ( R-HSA-6803207 ) R-HSA-6798139 Reaction Name: TP53 stimulates CASP10 expression See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome
MONDO:0011383	CASP10	Q92851	3.4.22.63	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-6803207 R-HSA-6803207 Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-141310 ( R-HSA-75157 ) R-HSA-141310 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-141316 ( R-HSA-75158 ) R-HSA-141316 Reaction Name: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-6798139 ( R-HSA-6803207 ) R-HSA-6798139 Reaction Name: TP53 stimulates CASP10 expression See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome
MONDO:0011508	CASP10	Q92851	3.4.22.63	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-6803207 R-HSA-6803207 Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-141310 ( R-HSA-75157 ) R-HSA-141310 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-141316 ( R-HSA-75158 ) R-HSA-141316 Reaction Name: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 See in Reactome R-HSA-6798139 ( R-HSA-6803207 ) R-HSA-6798139 Reaction Name: TP53 stimulates CASP10 expression See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome