DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.6)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	6
Number of reactions:	13

Search results (EC number: 3.4.21.6)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002049	F10	P00742	3.4.21.6	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140686 ( R-HSA-140875 ) R-HSA-140686 Reaction Name: factor Va + factor Xa -> Va:Xa complex (prothrombinase) See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140736 ( R-HSA-140834 ) R-HSA-140736 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140769 ( R-HSA-140834 ) R-HSA-140769 Reaction Name: factor VII -> factor VIIa See in Reactome R-HSA-140777 ( R-HSA-140834 ) R-HSA-140777 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) See in Reactome R-HSA-140825 ( R-HSA-140834 ) R-HSA-140825 Reaction Name: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-159733 ( R-HSA-159782 ) R-HSA-159733 Reaction Name: Furin cleaves pro-factor X to factor X See in Reactome R-HSA-159757 ( R-HSA-159763 ) R-HSA-159757 Reaction Name: Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159819 ( R-HSA-159740 ) R-HSA-159819 Reaction Name: GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) See in Reactome R-HSA-9015111 ( R-HSA-140875 ) R-HSA-9015111 Reaction Name: Factor Xa inhibitors binds Xa See in Reactome R-HSA-9015122 ( R-HSA-140875 ) R-HSA-9015122 Reaction Name: Factor Xa inhibitors bind Va:Xa See in Reactome
MONDO:0009212	F10	P00742	3.4.21.6	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140686 ( R-HSA-140875 ) R-HSA-140686 Reaction Name: factor Va + factor Xa -> Va:Xa complex (prothrombinase) See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140736 ( R-HSA-140834 ) R-HSA-140736 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140769 ( R-HSA-140834 ) R-HSA-140769 Reaction Name: factor VII -> factor VIIa See in Reactome R-HSA-140777 ( R-HSA-140834 ) R-HSA-140777 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) See in Reactome R-HSA-140825 ( R-HSA-140834 ) R-HSA-140825 Reaction Name: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-159733 ( R-HSA-159782 ) R-HSA-159733 Reaction Name: Furin cleaves pro-factor X to factor X See in Reactome R-HSA-159757 ( R-HSA-159763 ) R-HSA-159757 Reaction Name: Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159819 ( R-HSA-159740 ) R-HSA-159819 Reaction Name: GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) See in Reactome R-HSA-9015111 ( R-HSA-140875 ) R-HSA-9015111 Reaction Name: Factor Xa inhibitors binds Xa See in Reactome R-HSA-9015122 ( R-HSA-140875 ) R-HSA-9015122 Reaction Name: Factor Xa inhibitors bind Va:Xa See in Reactome