DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.45)

Number of enzymes:	1
Number of disease:	4
Number of reactomes:	1
Number of reactions:	10

Search results (EC number: 3.4.21.45)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007471	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0012594	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0013041	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome
MONDO:0014189	CFI	P05156	3.4.21.45	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-3266557 ( R-HSA-977606 ) R-HSA-3266557 Reaction Name: Factor I cleaves iC3b See in Reactome R-HSA-976743 ( R-HSA-977606 ) R-HSA-976743 Reaction Name: Factor I inactivates plasma Factor H-bound C3b See in Reactome R-HSA-976801 ( R-HSA-977606 ) R-HSA-976801 Reaction Name: Complement factor I complex formation See in Reactome R-HSA-976810 ( R-HSA-977606 ) R-HSA-976810 Reaction Name: Complement factor I binds to extracellular Factor H:C3b See in Reactome R-HSA-977359 ( R-HSA-977606 ) R-HSA-977359 Reaction Name: Complement factor I binds to membrane-associated Factor H:C3b See in Reactome R-HSA-977371 ( R-HSA-977606 ) R-HSA-977371 Reaction Name: Factor I inactivates Factor H-boundC3b See in Reactome R-HSA-977602 ( R-HSA-977606 ) R-HSA-977602 Reaction Name: Complement factor I binds to MCP, CR1:C4b, C3b See in Reactome R-HSA-977615 ( R-HSA-977606 ) R-HSA-977615 Reaction Name: Factor I inactivates MCP/CR1-bound C4b/C3b See in Reactome R-HSA-981637 ( R-HSA-977606 ) R-HSA-981637 Reaction Name: Complement factor I inactivates C4BP-bound C4b See in Reactome R-HSA-981658 ( R-HSA-977606 ) R-HSA-981658 Reaction Name: Complement factor I binds C4BP See in Reactome