DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.41)

Number of enzymes:	1
Number of disease:	4
Number of reactomes:	3
Number of reactions:	7

Search results (EC number: 3.4.21.41)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013743	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0014954	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0015699	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0020684	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome