DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.4)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	2
Number of reactions:	8

Search results (EC number: 3.4.21.4)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008185	PRSS1	P07477	3.4.21.4	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	Extracellular matrix organization Metabolism	R-HSA-1592316 ( R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-1604722 ( R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-3132753 ( R-HSA-196741 ) R-HSA-3132753 Reaction Name: Pancreatic proteases degrade TCN1:RCbl See in Reactome
MONDO:0013543	PRSS1	P07477	3.4.21.4	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	Extracellular matrix organization Metabolism	R-HSA-1592316 ( R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-1604722 ( R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-3132753 ( R-HSA-196741 ) R-HSA-3132753 Reaction Name: Pancreatic proteases degrade TCN1:RCbl See in Reactome
MONDO:0018989	PRSS1	P07477	3.4.21.4	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	Extracellular matrix organization Metabolism	R-HSA-1592316 ( R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-1604722 ( R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-3132753 ( R-HSA-196741 ) R-HSA-3132753 Reaction Name: Pancreatic proteases degrade TCN1:RCbl See in Reactome