DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.34)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	8

Search results (EC number: 3.4.21.34)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0012901	KLKB1	P03952	3.4.21.34	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome	Extracellular matrix organization Hemostasis	R-HSA-158218 ( R-HSA-140837 ) R-HSA-158218 Reaction Name: prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer See in Reactome R-HSA-158251 ( R-HSA-140837 ) R-HSA-158251 Reaction Name: prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer See in Reactome R-HSA-158311 ( R-HSA-140837 ) R-HSA-158311 Reaction Name: kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin See in Reactome R-HSA-158313 ( R-HSA-140837 ) R-HSA-158313 Reaction Name: factor XII -> factor XIIa See in Reactome R-HSA-158340 ( R-HSA-140837 ) R-HSA-158340 Reaction Name: kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin See in Reactome R-HSA-158399 ( R-HSA-140837 ) R-HSA-158399 Reaction Name: kallikrein binds SERPING1 See in Reactome R-HSA-1592316 ( R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome