DAR - Bologna Biocomputing Group

Search summary (EC number: 3.4.21.22)

Number of enzymes:	1
Number of disease:	7
Number of reactomes:	5
Number of reactions:	9

Search results (EC number: 3.4.21.22)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010432	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0010602	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015715	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015716	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015717	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015788	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0026768	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome