DAR - Bologna Biocomputing Group

Search results (EC number: 3.4.19.12)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001149	ALG13	Q9NP73	2.4.1.141 3.4.19.12	R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-446207 ( R-HSA-446193 ) R-HSA-446207 Reaction Name: ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP See in Reactome
MONDO:0006292	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0006486	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0007565	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome
MONDO:0009050	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome
MONDO:0009693	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0010472	ALG13	Q9NP73	2.4.1.141 3.4.19.12	R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-446207 ( R-HSA-446193 ) R-HSA-446207 Reaction Name: ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP See in Reactome
MONDO:0010487	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0010502	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0010510	USP27X	A6NNY8	3.4.19.12
MONDO:0010767	USP9Y	O00507	3.4.19.12
MONDO:0013340	UCHL1	P09936	3.4.19.12	R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-5690319 ( R-HSA-5689603 ) R-HSA-5690319 Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts See in Reactome
MONDO:0013692	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0014209	UCHL1	P09936	3.4.19.12	R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-5690319 ( R-HSA-5689603 ) R-HSA-5690319 Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts See in Reactome
MONDO:0014761	TNFAIP3	P21580	2.3.2.- 3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690845 ( R-HSA-5689896 ) R-HSA-5690845 Reaction Name: TNIPs bind TNFAIP3 (A20) See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5693055 ( R-HSA-5357905 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-688136 ( R-HSA-168638; R-HSA-5689896 ) R-HSA-688136 Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-937337 ( R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome
MONDO:0014805	USP7	Q93009	3.4.19.12	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins DNA Repair Signal Transduction	R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3215310 ( R-HSA-6804757 ) R-HSA-3215310 Reaction Name: USP7 deubiquitinates TP53 and counteracts MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014912	OTULIN	Q96BN8	3.4.19.12	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-8853515 ( R-HSA-8866652 ) R-HSA-8853515 Reaction Name: OTULIN,USP5 cleaves UBC yielding ubiquitin See in Reactome R-HSA-8853529 ( R-HSA-8866652 ) R-HSA-8853529 Reaction Name: OTULIN,USP5 cleaves UBB yielding ubiquitin See in Reactome
MONDO:0016642	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0017174	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017175	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017176	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0018416	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome
MONDO:0018821	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0019181	ALG13	Q9NP73	2.4.1.141 3.4.19.12	R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-446207 ( R-HSA-446193 ) R-HSA-446207 Reaction Name: ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP See in Reactome
MONDO:0019438	BAP1	Q92560	3.4.19.12	R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	Metabolism of proteins DNA Repair	R-HSA-5689630 ( R-HSA-5689603 ) R-HSA-5689630 Reaction Name: BAP1 binds BAP1-interacting complex See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5690759 ( R-HSA-5689603 ) R-HSA-5690759 Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 See in Reactome R-HSA-5690785 ( R-HSA-5689603 ) R-HSA-5690785 Reaction Name: BAP1 binds Ub-HCFC1 See in Reactome R-HSA-5690790 ( R-HSA-5689603 ) R-HSA-5690790 Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0025351	OTUD5	Q96G74	3.4.19.12	R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-936381 ( R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome
MONDO:0030872	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome
MONDO:0032662	EIF3F	O00303	3.4.19.12	R-HSA-72695 R-HSA-72695 Reactome Name: Formation of the ternary complex, and subsequently, the 43S complex See in Reactome R-HSA-72649 R-HSA-72649 Reactome Name: Translation initiation complex formation See in Reactome R-HSA-156827 R-HSA-156827 Reactome Name: L13a-mediated translational silencing of Ceruloplasmin expression See in Reactome R-HSA-72702 R-HSA-72702 Reactome Name: Ribosomal scanning and start codon recognition See in Reactome R-HSA-72689 R-HSA-72689 Reactome Name: Formation of a pool of free 40S subunits See in Reactome R-HSA-72706 R-HSA-72706 Reactome Name: GTP hydrolysis and joining of the 60S ribosomal subunit See in Reactome	R-HSA-72662 R-HSA-72662 Reactome Name: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S See in Reactome R-HSA-72613 R-HSA-72613 Reactome Name: Eukaryotic Translation Initiation See in Reactome R-HSA-72737 R-HSA-72737 Reactome Name: Cap-dependent Translation Initiation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism of proteins	R-HSA-156808 ( R-HSA-72649 ) R-HSA-156808 Reaction Name: Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation See in Reactome R-HSA-156823 ( R-HSA-156827 ) R-HSA-156823 Reaction Name: Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA See in Reactome R-HSA-157849 ( R-HSA-72649 ) R-HSA-157849 Reaction Name: Formation of translation initiation complexes containing mRNA that does not circularize See in Reactome R-HSA-72619 ( R-HSA-72706 ) R-HSA-72619 Reaction Name: eIF2:GTP is hydrolyzed, eIFs are released See in Reactome R-HSA-72621 ( R-HSA-72702 ) R-HSA-72621 Reaction Name: Ribosomal scanning See in Reactome R-HSA-72676 ( R-HSA-72689 ) R-HSA-72676 Reaction Name: eIF3 and eIF1A bind to the 40S subunit See in Reactome R-HSA-72691 ( R-HSA-72695 ) R-HSA-72691 Reaction Name: Formation of the 43S pre-initiation complex See in Reactome R-HSA-72697 ( R-HSA-72702 ) R-HSA-72697 Reaction Name: Start codon recognition See in Reactome
MONDO:0032794	USP45	Q70EL2	3.4.19.12	R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome	DNA Repair	R-HSA-5696465 ( R-HSA-5696395 ) R-HSA-5696465 Reaction Name: USP45 deubiquitinates ERCC1 See in Reactome
MONDO:0042977	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome
MONDO:0044319	OTUD6B	Q8N6M0	3.4.19.12

Number of enzymes:	16
Number of disease:	31
Number of reactomes:	34
Number of reactions:	86

Search summary (EC number: 3.4.19.12)

Search results (EC number: 3.4.19.12)

MONDO:0001149

R-HSA-446193

R-HSA-446203

R-HSA-392499

R-HSA-597592

R-HSA-446207

MONDO:0006292

R-HSA-5693565

R-HSA-5689603

R-HSA-5688426

R-HSA-5693606

R-HSA-392499

R-HSA-73894

R-HSA-597592

R-HSA-5693532

R-HSA-5689630

R-HSA-5689649

R-HSA-5690759

R-HSA-5690785

R-HSA-5690790

R-HSA-9700998

R-HSA-9701000

R-HSA-9701003

MONDO:0006486

R-HSA-5693565

R-HSA-5689603

R-HSA-5688426

R-HSA-5693606

R-HSA-392499

R-HSA-73894

R-HSA-597592

R-HSA-5693532

R-HSA-5689630

R-HSA-5689649

R-HSA-5690759

R-HSA-5690785

R-HSA-5690790

R-HSA-9700998

R-HSA-9701000

R-HSA-9701003

MONDO:0007565

R-HSA-5357786

R-HSA-168638

R-HSA-5357956

R-HSA-5689880

R-HSA-936440

R-HSA-5357905

R-HSA-5688426

R-HSA-168256

R-HSA-392499

R-HSA-168643

R-HSA-168928

R-HSA-597592

R-HSA-73887

R-HSA-75893

R-HSA-168249

R-HSA-162582

R-HSA-140978

R-HSA-5357776

R-HSA-5357831

R-HSA-5357845

R-HSA-5357860

R-HSA-5357928

R-HSA-5696627

R-HSA-741411

R-HSA-936390

MONDO:0009050

R-HSA-6807004

R-HSA-4641263

R-HSA-5689880

R-HSA-1358803

R-HSA-6806834

R-HSA-195721

R-HSA-5688426

R-HSA-392499

R-HSA-1227986

R-HSA-9006934

R-HSA-201681