DAR - Bologna Biocomputing Group

Search summary (EC number: 3.2.1.52)

Number of enzymes:	2
Number of disease:	7
Number of reactomes:	5
Number of reactions:	9

Search results (EC number: 3.2.1.52)

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0017721	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017722	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017723	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017724	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017725	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017726	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017728	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome

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