DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.4.35)

Number of enzymes:	7
Number of disease:	9
Number of reactomes:	6
Number of reactions:	9

Search results (EC number: 3.1.4.35)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008099	PDE6B	P35913	3.1.4.35	R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome R-HSA-2485179 R-HSA-2485179 Reactome Name: Activation of the phototransduction cascade See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Sensory Perception Signal Transduction	R-HSA-2584246 ( R-HSA-2514859 ) R-HSA-2584246 Reaction Name: GNAT1-GTP hydrolyses its bound GTP to GDP See in Reactome R-HSA-4086392 ( R-HSA-4086398 ) R-HSA-4086392 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-4086393 ( R-HSA-4086398 ) R-HSA-4086393 Reaction Name: G alpha t2 binds and activates PDE6 See in Reactome R-HSA-74059 ( R-HSA-2485179 ) R-HSA-74059 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-74065 ( R-HSA-2485179 ) R-HSA-74065 Reaction Name: GNAT1-GTP binds PDE6 and activates it See in Reactome
MONDO:0012398	PDE6H	Q13956	3.1.4.35
MONDO:0012505	PDE11A	Q9HCR9	3.1.4.53 3.1.4.35	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0013129	PDE6C	P51160	3.1.4.35
MONDO:0013315	PDE6G	P18545	3.1.4.35	R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome R-HSA-2485179 R-HSA-2485179 Reactome Name: Activation of the phototransduction cascade See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Sensory Perception Signal Transduction	R-HSA-2584246 ( R-HSA-2514859 ) R-HSA-2584246 Reaction Name: GNAT1-GTP hydrolyses its bound GTP to GDP See in Reactome R-HSA-4086392 ( R-HSA-4086398 ) R-HSA-4086392 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-4086393 ( R-HSA-4086398 ) R-HSA-4086393 Reaction Name: G alpha t2 binds and activates PDE6 See in Reactome R-HSA-74059 ( R-HSA-2485179 ) R-HSA-74059 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-74065 ( R-HSA-2485179 ) R-HSA-74065 Reaction Name: GNAT1-GTP binds PDE6 and activates it See in Reactome
MONDO:0013429	PDE6B	P35913	3.1.4.35	R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome R-HSA-2485179 R-HSA-2485179 Reactome Name: Activation of the phototransduction cascade See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Sensory Perception Signal Transduction	R-HSA-2584246 ( R-HSA-2514859 ) R-HSA-2584246 Reaction Name: GNAT1-GTP hydrolyses its bound GTP to GDP See in Reactome R-HSA-4086392 ( R-HSA-4086398 ) R-HSA-4086392 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-4086393 ( R-HSA-4086398 ) R-HSA-4086393 Reaction Name: G alpha t2 binds and activates PDE6 See in Reactome R-HSA-74059 ( R-HSA-2485179 ) R-HSA-74059 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-74065 ( R-HSA-2485179 ) R-HSA-74065 Reaction Name: GNAT1-GTP binds PDE6 and activates it See in Reactome
MONDO:0013437	PDE6A	P16499	3.1.4.35	R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-2514859 R-HSA-2514859 Reactome Name: Inactivation, recovery and regulation of the phototransduction cascade See in Reactome R-HSA-2485179 R-HSA-2485179 Reactome Name: Activation of the phototransduction cascade See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2514856 R-HSA-2514856 Reactome Name: The phototransduction cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Sensory Perception Signal Transduction	R-HSA-2584246 ( R-HSA-2514859 ) R-HSA-2584246 Reaction Name: GNAT1-GTP hydrolyses its bound GTP to GDP See in Reactome R-HSA-4086392 ( R-HSA-4086398 ) R-HSA-4086392 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-4086393 ( R-HSA-4086398 ) R-HSA-4086393 Reaction Name: G alpha t2 binds and activates PDE6 See in Reactome R-HSA-74059 ( R-HSA-2485179 ) R-HSA-74059 Reaction Name: PDE6 hydrolyses cGMP to GMP See in Reactome R-HSA-74065 ( R-HSA-2485179 ) R-HSA-74065 Reaction Name: GNAT1-GTP binds PDE6 and activates it See in Reactome
MONDO:0018852	PDE6C	P51160	3.1.4.35
MONDO:0029137	PDE1C	Q14123	3.1.4.- 3.1.4.35	R-HSA-111957 R-HSA-111957 Reactome Name: Cam-PDE 1 activation See in Reactome	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome	Signal Transduction	R-HSA-111955 ( R-HSA-111957 ) R-HSA-111955 Reaction Name: cAMP hydrolysis by Cam-PDE 1 See in Reactome R-HSA-111956 ( R-HSA-111957 ) R-HSA-111956 Reaction Name: Calmodulin activates Cam-PDE 1 See in Reactome