DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.4.11)

Number of enzymes:	7
Number of disease:	12
Number of reactomes:	19
Number of reactions:	53

Search results (EC number: 3.1.4.11)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0004948	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0007295	PLCB1	Q9NQ66	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-399997 R-HSA-399997 Reactome Name: Acetylcholine regulates insulin secretion See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-434316 R-HSA-434316 Reactome Name: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion See in Reactome R-HSA-500657 R-HSA-500657 Reactome Name: Presynaptic function of Kainate receptors See in Reactome R-HSA-418217 R-HSA-418217 Reactome Name: G beta:gamma signalling through PLC beta See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-451326 R-HSA-451326 Reactome Name: Activation of kainate receptors upon glutamate binding See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Neuronal System Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398040 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398040 Reaction Name: Gbeta:gamma activation of PLC beta See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome R-HSA-398193 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398193 Reaction Name: PLC beta-mediated PIP2 hydrolysis See in Reactome R-HSA-399998 ( R-HSA-399997; R-HSA-434316 ) R-HSA-399998 Reaction Name: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-400023 ( R-HSA-399997; R-HSA-434316 ) R-HSA-400023 Reaction Name: Gq alpha activates Phospholipase C beta See in Reactome R-HSA-500717 ( R-HSA-500657 ) R-HSA-500717 Reaction Name: Activation of GRIK3 homomer See in Reactome
MONDO:0007900	PLCD1	P51178	3.1.4.11	R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome
MONDO:0011234	PLCB4	Q15147	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome
MONDO:0012546	PLCE1	Q9P212	3.1.4.11	R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome
MONDO:0013389	PLCB1	Q9NQ66	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-399997 R-HSA-399997 Reactome Name: Acetylcholine regulates insulin secretion See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-434316 R-HSA-434316 Reactome Name: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion See in Reactome R-HSA-500657 R-HSA-500657 Reactome Name: Presynaptic function of Kainate receptors See in Reactome R-HSA-418217 R-HSA-418217 Reactome Name: G beta:gamma signalling through PLC beta See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-451326 R-HSA-451326 Reactome Name: Activation of kainate receptors upon glutamate binding See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Neuronal System Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398040 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398040 Reaction Name: Gbeta:gamma activation of PLC beta See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome R-HSA-398193 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398193 Reaction Name: PLC beta-mediated PIP2 hydrolysis See in Reactome R-HSA-399998 ( R-HSA-399997; R-HSA-434316 ) R-HSA-399998 Reaction Name: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-400023 ( R-HSA-399997; R-HSA-434316 ) R-HSA-400023 Reaction Name: Gq alpha activates Phospholipase C beta See in Reactome R-HSA-500717 ( R-HSA-500657 ) R-HSA-500717 Reaction Name: Activation of GRIK3 homomer See in Reactome
MONDO:0013766	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0013845	PLCB4	Q15147	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome
MONDO:0013944	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0014970	PLCZ1	Q86YW0	3.1.4.11	R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome
MONDO:0016557	PLCD1	P51178	3.1.4.11	R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome
MONDO:0030074	PLCB3	Q01970	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-399997 R-HSA-399997 Reactome Name: Acetylcholine regulates insulin secretion See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-434316 R-HSA-434316 Reactome Name: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion See in Reactome R-HSA-500657 R-HSA-500657 Reactome Name: Presynaptic function of Kainate receptors See in Reactome R-HSA-418217 R-HSA-418217 Reactome Name: G beta:gamma signalling through PLC beta See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-451326 R-HSA-451326 Reactome Name: Activation of kainate receptors upon glutamate binding See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Neuronal System Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398040 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398040 Reaction Name: Gbeta:gamma activation of PLC beta See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome R-HSA-398193 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398193 Reaction Name: PLC beta-mediated PIP2 hydrolysis See in Reactome R-HSA-399998 ( R-HSA-399997; R-HSA-434316 ) R-HSA-399998 Reaction Name: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-400023 ( R-HSA-399997; R-HSA-434316 ) R-HSA-400023 Reaction Name: Gq alpha activates Phospholipase C beta See in Reactome R-HSA-500717 ( R-HSA-500657 ) R-HSA-500717 Reaction Name: Activation of GRIK3 homomer See in Reactome