DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.3.86)

Number of enzymes:	5
Number of disease:	17
Number of reactomes:	12
Number of reactions:	35

Search results (EC number: 3.1.3.86)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0007342	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0008944	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0008995	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0008996	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0009567	INPP5K	Q9BT40	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome
MONDO:0009785	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0010013	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0010359	OCRL	Q01968	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Vesicle-mediated transport	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855213 ( R-HSA-1855204 ) R-HSA-1855213 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9017488 ( R-HSA-9013409 ) R-HSA-9017488 Reaction Name: RHOJ GAPs stimulate RHOJ GTPase activity See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0010645	OCRL	Q01968	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Vesicle-mediated transport	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855213 ( R-HSA-1855204 ) R-HSA-1855213 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9017488 ( R-HSA-9013409 ) R-HSA-9017488 Reaction Name: RHOJ GAPs stimulate RHOJ GTPase activity See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0012423	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0012640	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0012945	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0012986	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0016364	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0018998	INPP5E	Q9NRR6	3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-5624958 R-HSA-5624958 Reactome Name: ARL13B-mediated ciliary trafficking of INPP5E See in Reactome	R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5620920 R-HSA-5620920 Reactome Name: Cargo trafficking to the periciliary membrane See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-5624953 ( R-HSA-5624958 ) R-HSA-5624953 Reaction Name: ARL13B binds INPP5E See in Reactome R-HSA-5624954 ( R-HSA-5624958 ) R-HSA-5624954 Reaction Name: INPP5E translocates to the primary cilium See in Reactome R-HSA-5624956 ( R-HSA-5624958 ) R-HSA-5624956 Reaction Name: PDE6D binds INPP5E See in Reactome R-HSA-5638012 ( R-HSA-5624958 ) R-HSA-5638012 Reaction Name: PDE6D dissociates from ARL13B:INPP5E See in Reactome
MONDO:0024607	INPP5K	Q9BT40	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome