MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011537 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011738 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011789 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011962 |
MONDO:0011962
Disease Name: endometrial cancer
OMIM id: OMIM:608089
All associated enzymes in DAR:
PTEN
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0013092 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0015293 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0016995 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0017571 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018338 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018872 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8851011
Reaction Name: TRIM27 polyubiquitinates PTEN
|