MONDO:0001071 |
MONDO:0001071
Disease Name: intellectual disability
Orphanet id: Orphanet:319658
All associated enzymes in DAR:
CYP2U1
DHX16
CBS
POLG
UFSP2
P4HTM
PDIA3
DHX30
TET3
ALG3
NAGLU
CHD3
SMPD1
DHX34
GCH1
CARNMT1
CYP27A1
ABCD1
CHD2
DDX54
INO80
PTPN4
DHX37
PTPN4 |
P29074 |
3.1.3.48
|
R-HSA-9008059
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-9022699
R-HSA-9022699
Reactome Name: MECP2 regulates neuronal receptors and channels
See in Reactome
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-449147
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-168898
R-HSA-168249
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-446652
R-HSA-73857
|
Gene expression (Transcription)
Immune System
|
R-HSA-2201341
(
R-HSA-166016
)
R-HSA-9006585
(
R-HSA-9022699
)
R-HSA-9006585
Reaction Name: PTPN4 gene expression is stimulated by MECP2
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
|
MONDO:0002049 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0005062 |
MONDO:0005062
Disease Name: lymphoma
OMIM id: OMIM:605027
Orphanet id: Orphanet:223735
All associated enzymes in DAR:
PTPN11
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0005392 |
MONDO:0005392
Disease Name: scoliosis
All associated enzymes in DAR:
PTPN11
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PTPN12 |
Q05209 |
3.1.3.48
|
R-HSA-186797
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-182971
R-HSA-9008059
|
R-HSA-449147
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1227986
R-HSA-177929
R-HSA-162582
R-HSA-446652
|
Immune System
Signal Transduction
|
R-HSA-1963578
(
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-8863804
(
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864036
(
R-HSA-186797
)
R-HSA-8864036
Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021
See in Reactome
R-HSA-8934465
(
R-HSA-1250196
)
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PTPRJ |
Q12913 |
3.1.3.48
|
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-6798695
R-HSA-9706369
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-6806834
R-HSA-168256
R-HSA-168249
R-HSA-202403
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807008
(
R-HSA-6807004
)
R-HSA-9698408
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007236 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0007256 |
CDKN3 |
Q16667 |
3.1.3.16
3.1.3.48
|
|
|
|
|
MONDO:0007915 |
PTPN22 |
Q9Y2R2 |
3.1.3.48
|
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168256
R-HSA-202403
R-HSA-1280218
|
Immune System
|
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855375
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007979 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008104 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008383 |
PTPN22 |
Q9Y2R2 |
3.1.3.48
|
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168256
R-HSA-202403
R-HSA-1280218
|
Immune System
|
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855375
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
|
MONDO:0008586 |
PTPN14 |
Q15678 |
3.1.3.48
|
R-HSA-9008059
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-446652
|
Immune System
|
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
|
MONDO:0008661 |
PTPN22 |
Q9Y2R2 |
3.1.3.48
|
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168256
R-HSA-202403
R-HSA-1280218
|
Immune System
|
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855375
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
|
MONDO:0009100 |
MONDO:0009100
Disease Name: IDDM 1
OMIM id: OMIM:222100
All associated enzymes in DAR:
PTPN22
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTPN22 |
Q9Y2R2 |
3.1.3.48
|
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168256
R-HSA-202403
R-HSA-1280218
|
Immune System
|
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855375
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011031 |
EYA4 |
O95677 |
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0011258 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0011537 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011541 |
EYA4 |
O95677 |
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0011738 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011789 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011908 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0011962 |
MONDO:0011962
Disease Name: endometrial cancer
OMIM id: OMIM:608089
All associated enzymes in DAR:
PTEN
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0012091 |
CDC14A |
Q9UNH5 |
3.1.3.16
3.1.3.48
|
R-HSA-5687128
R-HSA-176407
R-HSA-176407
Reactome Name: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
See in Reactome
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69278
R-HSA-1640170
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-174124
(
R-HSA-176407
)
R-HSA-174124
Reaction Name: Dephosphorylation of phospho-Cdh1
See in Reactome
R-HSA-5692749
(
R-HSA-5687128
)
R-HSA-5692754
(
R-HSA-5687128
)
R-HSA-5692754
Reaction Name: CDC14A,B dephosphorylate p-3S,T MAPK6
See in Reactome
R-HSA-5692764
(
R-HSA-5687128
)
|
MONDO:0012163 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0012371 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0013092 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0013249 |
PTPRQ |
Q9UMZ3 |
3.1.3.-
3.1.3.48
|
|
|
|
|
MONDO:0013308 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0013324 |
PTPN14 |
Q15678 |
3.1.3.48
|
R-HSA-9008059
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-446652
|
Immune System
|
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
|
MONDO:0013619 |
PTPRO |
Q16827 |
3.1.3.48
|
R-HSA-9034015
|
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-166520
R-HSA-162582
|
Signal Transduction
|
R-HSA-9603719
(
R-HSA-9034015
)
R-HSA-9603719
Reaction Name: Protein tyrosine phosphatases dephosphorylate NTRK3
See in Reactome
|
MONDO:0014105 |
DUSP6 |
Q16828 |
3.1.3.16
3.1.3.48
|
R-HSA-202670
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-198753
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5684996
R-HSA-5673001
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-449147
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-203797
(
R-HSA-166016;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
|
MONDO:0014231 |
DNAJC6 |
O75061 |
3.1.3.48
|
R-HSA-432722
R-HSA-432722
Reactome Name: Golgi Associated Vesicle Biogenesis
See in Reactome
R-HSA-8856828
R-HSA-432720
|
R-HSA-199991
R-HSA-199992
R-HSA-199992
Reactome Name: trans-Golgi Network Vesicle Budding
See in Reactome
R-HSA-5653656
|
Vesicle-mediated transport
|
R-HSA-421836
(
R-HSA-432722
)
R-HSA-421836
Reaction Name: trans-Golgi Network Derived Vesicle Uncoating
See in Reactome
R-HSA-432688
(
R-HSA-432720
)
R-HSA-432688
Reaction Name: trans-Golgi Network Derived Lysosomal Vesicle Uncoating
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
|
MONDO:0014450 |
PTPRF |
P10586 |
3.1.3.48
|
R-HSA-8849932
R-HSA-8849932
Reactome Name: Synaptic adhesion-like molecules
See in Reactome
R-HSA-388844
R-HSA-388844
Reactome Name: Receptor-type tyrosine-protein phosphatases
See in Reactome
|
R-HSA-112316
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
|
Neuronal System
|
R-HSA-388824
(
R-HSA-388844
)
R-HSA-388824
Reaction Name: PTPRF, PTPRS, PTPRD bind Liprins
See in Reactome
R-HSA-6798258
(
R-HSA-388844
)
R-HSA-6798258
Reaction Name: PRTPRF, PTPRS, PTPRD bind LRRC4B
See in Reactome
R-HSA-8855648
(
R-HSA-8849932
)
|
MONDO:0015293 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0015702 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0016225 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
|
MONDO:0016995 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0016996 |
PTPRS |
Q13332 |
3.1.3.48
|
R-HSA-3000178
R-HSA-9034015
R-HSA-8849932
R-HSA-8849932
Reactome Name: Synaptic adhesion-like molecules
See in Reactome
R-HSA-388844
R-HSA-388844
Reactome Name: Receptor-type tyrosine-protein phosphatases
See in Reactome
|
R-HSA-166520
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-112316
R-HSA-162582
|
Extracellular matrix organization
Neuronal System
Signal Transduction
|
R-HSA-2467659
(
R-HSA-3000178
)
R-HSA-388824
(
R-HSA-388844
)
R-HSA-388824
Reaction Name: PTPRF, PTPRS, PTPRD bind Liprins
See in Reactome
R-HSA-6798257
(
R-HSA-388844
)
R-HSA-6798258
(
R-HSA-388844
)
R-HSA-6798258
Reaction Name: PRTPRF, PTPRS, PTPRD bind LRRC4B
See in Reactome
R-HSA-8855648
(
R-HSA-8849932
)
R-HSA-9603719
(
R-HSA-9034015
)
R-HSA-9603719
Reaction Name: Protein tyrosine phosphatases dephosphorylate NTRK3
See in Reactome
|
MONDO:0017571 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018338 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018872 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0019002 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0019087 |
PTPN3 |
P26045 |
3.1.3.48
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-182971
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5684996
R-HSA-177929
R-HSA-162582
R-HSA-5673001
|
Signal Transduction
|
R-HSA-8867047
(
R-HSA-182971
)
R-HSA-8867654
(
R-HSA-5675221
)
R-HSA-8867654
Reaction Name: PTPN3 binds p-T183,Y185 MAPK12
See in Reactome
R-HSA-8867658
(
R-HSA-5675221
)
R-HSA-8868118
(
R-HSA-5675221
)
|
MONDO:0021067 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0021427 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0021571 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0023122 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0024532 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0030046 |
PTPN23 |
Q9H3S7 |
3.1.3.48
|
R-HSA-9008059
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-446652
|
Immune System
|
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
|
MONDO:0033260 |
PTPRQ |
Q9UMZ3 |
3.1.3.-
3.1.3.48
|
|
|
|
|
MONDO:0044638 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044704 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044705 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044740 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0100082 |
PTPN11 |
Q06124 |
3.1.3.48
|
R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Cell-Cell communication
Developmental Biology
Gene expression (Transcription)
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-166016;
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
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R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
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