MONDO:0005012 |
PPP6C |
O00743 |
3.1.3.16
|
R-HSA-171319
R-HSA-171319
Reactome Name: Telomere Extension By Telomerase
See in Reactome
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
|
R-HSA-180786
R-HSA-157579
R-HSA-392499
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1640170
R-HSA-73886
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-5653656
|
Metabolism of proteins
Cell Cycle
Vesicle-mediated transport
|
R-HSA-163096
(
R-HSA-171319
)
R-HSA-163096
Reaction Name: Recruitment of Telomerase RNP to the Telomeric Chromosome End
See in Reactome
R-HSA-5694421
(
R-HSA-204005
)
R-HSA-9686524
(
R-HSA-171319
)
R-HSA-9686524
Reaction Name: PP6-PPP6R3 dephosphorylates TERF2
See in Reactome
|
MONDO:0005097 |
PPP6C |
O00743 |
3.1.3.16
|
R-HSA-171319
R-HSA-171319
Reactome Name: Telomere Extension By Telomerase
See in Reactome
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
|
R-HSA-180786
R-HSA-157579
R-HSA-392499
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1640170
R-HSA-73886
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-5653656
|
Metabolism of proteins
Cell Cycle
Vesicle-mediated transport
|
R-HSA-163096
(
R-HSA-171319
)
R-HSA-163096
Reaction Name: Recruitment of Telomerase RNP to the Telomeric Chromosome End
See in Reactome
R-HSA-5694421
(
R-HSA-204005
)
R-HSA-9686524
(
R-HSA-171319
)
R-HSA-9686524
Reaction Name: PP6-PPP6R3 dephosphorylates TERF2
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007236 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0007256 |
CDKN3 |
Q16667 |
3.1.3.16
3.1.3.48
|
|
|
|
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008170 |
PPM1D |
O15297 |
3.1.3.16
|
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
|
R-HSA-212436
R-HSA-74160
R-HSA-73857
|
Gene expression (Transcription)
|
R-HSA-9008822
(
R-HSA-8878166
)
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008995 |
FIG4 |
Q92562 |
3.1.3.16
3.1.3.-
3.1.3.36
3.1.3.86
|
R-HSA-1660514
R-HSA-1660514
Reactome Name: Synthesis of PIPs at the Golgi membrane
See in Reactome
R-HSA-1660516
R-HSA-1660516
Reactome Name: Synthesis of PIPs at the early endosome membrane
See in Reactome
R-HSA-1660517
R-HSA-1660517
Reactome Name: Synthesis of PIPs at the late endosome membrane
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-1483257
R-HSA-1483255
|
Metabolism
|
R-HSA-1675866
(
R-HSA-1660517
)
R-HSA-1675866
Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675910
(
R-HSA-1660517
)
R-HSA-1675910
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675921
(
R-HSA-1660514
)
R-HSA-1675921
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
See in Reactome
R-HSA-1676005
(
R-HSA-1660514
)
R-HSA-1676005
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
See in Reactome
R-HSA-1676020
(
R-HSA-1660517
)
R-HSA-1676020
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
See in Reactome
R-HSA-1676168
(
R-HSA-1660516
)
R-HSA-1676168
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
See in Reactome
R-HSA-1676174
(
R-HSA-1660516
)
R-HSA-1676174
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
See in Reactome
|
MONDO:0009072 |
PPP1CB |
P62140 |
3.1.3.16
3.1.3.53
|
R-HSA-400253
R-HSA-5625900
R-HSA-5625740
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-163560
R-HSA-5627117
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-5673000
R-HSA-5627123
|
R-HSA-195258
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-194315
R-HSA-453274
R-HSA-556833
R-HSA-69278
R-HSA-1430728
R-HSA-162582
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-8979227
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-5684996
R-HSA-69275
R-HSA-5673001
|
Circadian Clock
Metabolism
Signal Transduction
Cell Cycle
|
R-HSA-163568
(
R-HSA-163560
)
R-HSA-163568
Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate
See in Reactome
R-HSA-178178
(
R-HSA-2173788
)
R-HSA-178189
(
R-HSA-2173788
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-3002811
(
R-HSA-2565942
)
R-HSA-3002811
Reaction Name: Myosin phosphatase dephosphorylates PLK1
See in Reactome
R-HSA-400382
(
R-HSA-400253
)
R-HSA-400382
Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins
See in Reactome
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419232
(
R-HSA-5625740;
R-HSA-5627117;
R-HSA-5627123
)
R-HSA-419232
Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain
See in Reactome
R-HSA-5668947
(
R-HSA-5627123
)
R-HSA-5668947
Reaction Name: PAK1 phosphorylates myosin phosphatase
See in Reactome
R-HSA-5668978
(
R-HSA-5627123
)
R-HSA-5668978
Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
See in Reactome
R-HSA-5671772
(
R-HSA-5625740
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-9658445
(
R-HSA-5673000
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011258 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0011402 |
CTDP1 |
Q9Y5B0 |
3.1.3.16
|
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-212436
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73857
R-HSA-74160
|
Gene expression (Transcription)
|
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112381
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112381
Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-112392
(
R-HSA-674695
)
R-HSA-112392
Reaction Name: Resumption of elongation after recovery from pausing
See in Reactome
R-HSA-112395
(
R-HSA-674695
)
R-HSA-112395
Reaction Name: Abortive termination of elongation after arrest
See in Reactome
R-HSA-112396
(
R-HSA-75955
)
R-HSA-112396
Reaction Name: Separation of elongating transcript from template
See in Reactome
R-HSA-113402
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-113402
Reaction Name: Formation of DSIF:NELF:early elongation complex
See in Reactome
R-HSA-113407
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-113407
Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated)
See in Reactome
R-HSA-113409
(
R-HSA-674695
)
R-HSA-113409
Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF
See in Reactome
R-HSA-113411
(
R-HSA-674695
)
R-HSA-113411
Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
See in Reactome
R-HSA-113412
(
R-HSA-75955
)
R-HSA-113412
Reaction Name: Pol II elongation complex moves on the template as transcript elongates
See in Reactome
R-HSA-113413
(
R-HSA-674695
)
R-HSA-113413
Reaction Name: TFIIS-mediated recovery of elongation from arrest
See in Reactome
R-HSA-113414
(
R-HSA-674695
)
R-HSA-113414
Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
See in Reactome
R-HSA-113429
(
R-HSA-674695
)
R-HSA-113429
Reaction Name: Elongating transcript encounters a lesion in the template
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
|
MONDO:0011537 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011738 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011789 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011962 |
MONDO:0011962
Disease Name: endometrial cancer
OMIM id: OMIM:608089
All associated enzymes in DAR:
PTEN
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0012091 |
CDC14A |
Q9UNH5 |
3.1.3.16
3.1.3.48
|
R-HSA-5687128
R-HSA-176407
R-HSA-176407
Reactome Name: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
See in Reactome
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69278
R-HSA-1640170
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-174124
(
R-HSA-176407
)
R-HSA-174124
Reaction Name: Dephosphorylation of phospho-Cdh1
See in Reactome
R-HSA-5692749
(
R-HSA-5687128
)
R-HSA-5692754
(
R-HSA-5687128
)
R-HSA-5692754
Reaction Name: CDC14A,B dephosphorylate p-3S,T MAPK6
See in Reactome
R-HSA-5692764
(
R-HSA-5687128
)
|
MONDO:0012640 |
FIG4 |
Q92562 |
3.1.3.16
3.1.3.-
3.1.3.36
3.1.3.86
|
R-HSA-1660514
R-HSA-1660514
Reactome Name: Synthesis of PIPs at the Golgi membrane
See in Reactome
R-HSA-1660516
R-HSA-1660516
Reactome Name: Synthesis of PIPs at the early endosome membrane
See in Reactome
R-HSA-1660517
R-HSA-1660517
Reactome Name: Synthesis of PIPs at the late endosome membrane
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-1483257
R-HSA-1483255
|
Metabolism
|
R-HSA-1675866
(
R-HSA-1660517
)
R-HSA-1675866
Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675910
(
R-HSA-1660517
)
R-HSA-1675910
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675921
(
R-HSA-1660514
)
R-HSA-1675921
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
See in Reactome
R-HSA-1676005
(
R-HSA-1660514
)
R-HSA-1676005
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
See in Reactome
R-HSA-1676020
(
R-HSA-1660517
)
R-HSA-1676020
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
See in Reactome
R-HSA-1676168
(
R-HSA-1660516
)
R-HSA-1676168
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
See in Reactome
R-HSA-1676174
(
R-HSA-1660516
)
R-HSA-1676174
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
See in Reactome
|
MONDO:0012945 |
FIG4 |
Q92562 |
3.1.3.16
3.1.3.-
3.1.3.36
3.1.3.86
|
R-HSA-1660514
R-HSA-1660514
Reactome Name: Synthesis of PIPs at the Golgi membrane
See in Reactome
R-HSA-1660516
R-HSA-1660516
Reactome Name: Synthesis of PIPs at the early endosome membrane
See in Reactome
R-HSA-1660517
R-HSA-1660517
Reactome Name: Synthesis of PIPs at the late endosome membrane
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-1483257
R-HSA-1483255
|
Metabolism
|
R-HSA-1675866
(
R-HSA-1660517
)
R-HSA-1675866
Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675910
(
R-HSA-1660517
)
R-HSA-1675910
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675921
(
R-HSA-1660514
)
R-HSA-1675921
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
See in Reactome
R-HSA-1676005
(
R-HSA-1660514
)
R-HSA-1676005
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
See in Reactome
R-HSA-1676020
(
R-HSA-1660517
)
R-HSA-1676020
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
See in Reactome
R-HSA-1676168
(
R-HSA-1660516
)
R-HSA-1676168
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
See in Reactome
R-HSA-1676174
(
R-HSA-1660516
)
R-HSA-1676174
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
See in Reactome
|
MONDO:0012986 |
FIG4 |
Q92562 |
3.1.3.16
3.1.3.-
3.1.3.36
3.1.3.86
|
R-HSA-1660514
R-HSA-1660514
Reactome Name: Synthesis of PIPs at the Golgi membrane
See in Reactome
R-HSA-1660516
R-HSA-1660516
Reactome Name: Synthesis of PIPs at the early endosome membrane
See in Reactome
R-HSA-1660517
R-HSA-1660517
Reactome Name: Synthesis of PIPs at the late endosome membrane
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-1483257
R-HSA-1483255
|
Metabolism
|
R-HSA-1675866
(
R-HSA-1660517
)
R-HSA-1675866
Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675910
(
R-HSA-1660517
)
R-HSA-1675910
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675921
(
R-HSA-1660514
)
R-HSA-1675921
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
See in Reactome
R-HSA-1676005
(
R-HSA-1660514
)
R-HSA-1676005
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
See in Reactome
R-HSA-1676020
(
R-HSA-1660517
)
R-HSA-1676020
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
See in Reactome
R-HSA-1676168
(
R-HSA-1660516
)
R-HSA-1676168
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
See in Reactome
R-HSA-1676174
(
R-HSA-1660516
)
R-HSA-1676174
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
See in Reactome
|
MONDO:0013092 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0014057 |
PPM1K |
Q8N3J5 |
3.1.3.16
|
R-HSA-70895
R-HSA-70895
Reactome Name: Branched-chain amino acid catabolism
See in Reactome
|
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-1430728
|
Metabolism
|
R-HSA-5693153
(
R-HSA-70895
)
R-HSA-5693153
Reaction Name: PPM1K dephosphorylates p-BCKDH
See in Reactome
|
MONDO:0014105 |
DUSP6 |
Q16828 |
3.1.3.16
3.1.3.48
|
R-HSA-202670
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-198753
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5684996
R-HSA-5673001
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-449147
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-203797
(
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
|
MONDO:0015293 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0015802 |
PPP3CA |
Q08209 |
3.1.3.16
|
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-4086398
R-HSA-180024
R-HSA-2025928
R-HSA-5607763
R-HSA-5607763
Reactome Name: CLEC7A (Dectin-1) induces NFAT activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-195721
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-418594
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-388396
R-HSA-168249
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-5607764
R-HSA-111885
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-201783
(
R-HSA-180024
)
R-HSA-201783
Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin
See in Reactome
R-HSA-201787
(
R-HSA-180024
)
R-HSA-201787
Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-2025882
(
R-HSA-2025928
)
R-HSA-2025882
Reaction Name: Calcineurin dephosphorylates NFATC1,2,3
See in Reactome
R-HSA-2025890
(
R-HSA-2025928
)
R-HSA-2730849
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730849
Reaction Name: Calcineurin binds and dephosphorylates NFAT
See in Reactome
R-HSA-2730867
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730867
Reaction Name: Translocation of CaN:CaM:NFAT to nucleus
See in Reactome
R-HSA-2730872
(
R-HSA-2871809;
R-HSA-4086398;
R-HSA-5607763
)
R-HSA-4551451
(
R-HSA-4086398
)
R-HSA-4551451
Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
See in Reactome
R-HSA-4551465
(
R-HSA-4086398
)
R-HSA-4551465
Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus
See in Reactome
|
MONDO:0016419 |
PPM1D |
O15297 |
3.1.3.16
|
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
|
R-HSA-212436
R-HSA-74160
R-HSA-73857
|
Gene expression (Transcription)
|
R-HSA-9008822
(
R-HSA-8878166
)
|
MONDO:0016995 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0017571 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018338 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018614 |
PPP3CA |
Q08209 |
3.1.3.16
|
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-4086398
R-HSA-180024
R-HSA-2025928
R-HSA-5607763
R-HSA-5607763
Reactome Name: CLEC7A (Dectin-1) induces NFAT activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-195721
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-418594
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-388396
R-HSA-168249
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-5607764
R-HSA-111885
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-201783
(
R-HSA-180024
)
R-HSA-201783
Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin
See in Reactome
R-HSA-201787
(
R-HSA-180024
)
R-HSA-201787
Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-2025882
(
R-HSA-2025928
)
R-HSA-2025882
Reaction Name: Calcineurin dephosphorylates NFATC1,2,3
See in Reactome
R-HSA-2025890
(
R-HSA-2025928
)
R-HSA-2730849
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730849
Reaction Name: Calcineurin binds and dephosphorylates NFAT
See in Reactome
R-HSA-2730867
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730867
Reaction Name: Translocation of CaN:CaM:NFAT to nucleus
See in Reactome
R-HSA-2730872
(
R-HSA-2871809;
R-HSA-4086398;
R-HSA-5607763
)
R-HSA-4551451
(
R-HSA-4086398
)
R-HSA-4551451
Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
See in Reactome
R-HSA-4551465
(
R-HSA-4086398
)
R-HSA-4551465
Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus
See in Reactome
|
MONDO:0018872 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018997 |
PPP1CB |
P62140 |
3.1.3.16
3.1.3.53
|
R-HSA-400253
R-HSA-5625900
R-HSA-5625740
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-163560
R-HSA-5627117
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-5673000
R-HSA-5627123
|
R-HSA-195258
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-194315
R-HSA-453274
R-HSA-556833
R-HSA-69278
R-HSA-1430728
R-HSA-162582
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-8979227
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-5684996
R-HSA-69275
R-HSA-5673001
|
Circadian Clock
Metabolism
Signal Transduction
Cell Cycle
|
R-HSA-163568
(
R-HSA-163560
)
R-HSA-163568
Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate
See in Reactome
R-HSA-178178
(
R-HSA-2173788
)
R-HSA-178189
(
R-HSA-2173788
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-3002811
(
R-HSA-2565942
)
R-HSA-3002811
Reaction Name: Myosin phosphatase dephosphorylates PLK1
See in Reactome
R-HSA-400382
(
R-HSA-400253
)
R-HSA-400382
Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins
See in Reactome
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419232
(
R-HSA-5625740;
R-HSA-5627117;
R-HSA-5627123
)
R-HSA-419232
Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain
See in Reactome
R-HSA-5668947
(
R-HSA-5627123
)
R-HSA-5668947
Reaction Name: PAK1 phosphorylates myosin phosphatase
See in Reactome
R-HSA-5668978
(
R-HSA-5627123
)
R-HSA-5668978
Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
See in Reactome
R-HSA-5671772
(
R-HSA-5625740
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-9658445
(
R-HSA-5673000
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0019002 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0020630 |
PPP3CA |
Q08209 |
3.1.3.16
|
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-4086398
R-HSA-180024
R-HSA-2025928
R-HSA-5607763
R-HSA-5607763
Reactome Name: CLEC7A (Dectin-1) induces NFAT activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-195721
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-418594
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-388396
R-HSA-168249
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-5607764
R-HSA-111885
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-201783
(
R-HSA-180024
)
R-HSA-201783
Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin
See in Reactome
R-HSA-201787
(
R-HSA-180024
)
R-HSA-201787
Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-2025882
(
R-HSA-2025928
)
R-HSA-2025882
Reaction Name: Calcineurin dephosphorylates NFATC1,2,3
See in Reactome
R-HSA-2025890
(
R-HSA-2025928
)
R-HSA-2730849
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730849
Reaction Name: Calcineurin binds and dephosphorylates NFAT
See in Reactome
R-HSA-2730867
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730867
Reaction Name: Translocation of CaN:CaM:NFAT to nucleus
See in Reactome
R-HSA-2730872
(
R-HSA-2871809;
R-HSA-4086398;
R-HSA-5607763
)
R-HSA-4551451
(
R-HSA-4086398
)
R-HSA-4551451
Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
See in Reactome
R-HSA-4551465
(
R-HSA-4086398
)
R-HSA-4551465
Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus
See in Reactome
|
MONDO:0021067 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0021427 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0023122 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0024532 |
EYA1 |
Q99502 |
3.1.3.16
3.1.3.48
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
|
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
|
DNA Repair
|
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
|
MONDO:0032642 |
PPP3CA |
Q08209 |
3.1.3.16
|
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-4086398
R-HSA-180024
R-HSA-2025928
R-HSA-5607763
R-HSA-5607763
Reactome Name: CLEC7A (Dectin-1) induces NFAT activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-195721
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-418594
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-388396
R-HSA-168249
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-5607764
R-HSA-111885
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-201783
(
R-HSA-180024
)
R-HSA-201783
Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin
See in Reactome
R-HSA-201787
(
R-HSA-180024
)
R-HSA-201787
Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-2025882
(
R-HSA-2025928
)
R-HSA-2025882
Reaction Name: Calcineurin dephosphorylates NFATC1,2,3
See in Reactome
R-HSA-2025890
(
R-HSA-2025928
)
R-HSA-2730849
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730849
Reaction Name: Calcineurin binds and dephosphorylates NFAT
See in Reactome
R-HSA-2730867
(
R-HSA-2871809;
R-HSA-5607763
)
R-HSA-2730867
Reaction Name: Translocation of CaN:CaM:NFAT to nucleus
See in Reactome
R-HSA-2730872
(
R-HSA-2871809;
R-HSA-4086398;
R-HSA-5607763
)
R-HSA-4551451
(
R-HSA-4086398
)
R-HSA-4551451
Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
See in Reactome
R-HSA-4551465
(
R-HSA-4086398
)
R-HSA-4551465
Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus
See in Reactome
|
MONDO:0032697 |
PPP2CA |
P67775 |
3.1.3.16
|
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-198753
R-HSA-2995383
R-HSA-2995383
Reactome Name: Initiation of Nuclear Envelope (NE) Reformation
See in Reactome
R-HSA-4641262
R-HSA-4641262
Reactome Name: Disassembly of the destruction complex and recruitment of AXIN to the membrane
See in Reactome
R-HSA-5673000
R-HSA-180024
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2465910
R-HSA-2465910
Reactome Name: MASTL Facilitates Mitotic Progression
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-389513
R-HSA-196299
R-HSA-196299
Reactome Name: Beta-catenin phosphorylation cascade
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-432142
R-HSA-113501
R-HSA-113501
Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-5663220
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-69273
R-HSA-69273
Reactome Name: Cyclin A/B1/B2 associated events during G2/M transition
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-163767
R-HSA-163767
Reactome Name: PP2A-mediated dephosphorylation of key metabolic factors
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-975957
R-HSA-975957
Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-202670
R-HSA-68877
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-70326
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-418594
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-194315
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-1257604
R-HSA-1640170
R-HSA-5684996
R-HSA-1280218
R-HSA-5673001
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-71387
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-69620
R-HSA-69236
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-448424
R-HSA-418346
R-HSA-388396
R-HSA-166166
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-5654743
R-HSA-69275
R-HSA-5654741
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-168256
R-HSA-8953854
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-68882
R-HSA-2995410
R-HSA-2995410
Reactome Name: Nuclear Envelope (NE) Reassembly
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-168898
R-HSA-187037
R-HSA-5633007
R-HSA-450294
R-HSA-195721
R-HSA-166520
R-HSA-372790
R-HSA-5654738
R-HSA-69206
R-HSA-5654736
R-HSA-111885
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-109582
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-113510
R-HSA-113510
Reactome Name: E2F mediated regulation of DNA replication
See in Reactome
R-HSA-927802
R-HSA-69618
R-HSA-162582
R-HSA-68875
|
Metabolism
Cell Cycle
Gene expression (Transcription)
Immune System
Metabolism of RNA
Hemostasis
Signal Transduction
|
R-HSA-113503
(
R-HSA-113501
)
R-HSA-113503
Reaction Name: PP2A mediated localization of RB1 protein in chromatin
See in Reactome
R-HSA-1295599
(
R-HSA-1295596
)
R-HSA-1295599
Reaction Name: SPRY2 translocates to the plasma membrane
See in Reactome
R-HSA-1295609
(
R-HSA-1295596
)
R-HSA-1295609
Reaction Name: SRC phosphorylates SPRY2 on Y55 and Y227
See in Reactome
R-HSA-1295613
(
R-HSA-1295596
)
R-HSA-1295622
(
R-HSA-1295596
)
R-HSA-1295632
(
R-HSA-1295596
)
R-HSA-1363274
(
R-HSA-69231
)
R-HSA-1363274
Reaction Name: Dephosphorylation of p107 (RBL1) by PP2A
See in Reactome
R-HSA-1363276
(
R-HSA-69231
)
R-HSA-1363276
Reaction Name: Dephosphorylation of p130 (RBL2) by PP2A
See in Reactome
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1549564
(
R-HSA-1295596
)
R-HSA-163688
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-163688
Reaction Name: Dephosphorylation of pChREBP (Thr 666) by PP2A
See in Reactome
R-HSA-163689
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-163689
Reaction Name: Dephosphorylation of pChREBP (Ser 196) by PP2A
See in Reactome
R-HSA-163750
(
R-HSA-163685;
R-HSA-163767;
R-HSA-9634600
)
R-HSA-163750
Reaction Name: Dephosphorylation of phosphoPFKFB1 by PP2A complex
See in Reactome
R-HSA-163769
(
R-HSA-163685
)
R-HSA-163769
Reaction Name: Activation of PP2A by Xylulose-5-phosphate
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-164056
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-164056
Reaction Name: Dephosphorylation of pChREBP (Ser 568) by PP2A
See in Reactome
R-HSA-195251
(
R-HSA-195253
)
R-HSA-195251
Reaction Name: Assembly of the destruction complex
See in Reactome
R-HSA-195275
(
R-HSA-195253
)
R-HSA-195275
Reaction Name: Phosphorylation of APC component of the destruction complex
See in Reactome
R-HSA-195280
(
R-HSA-195253
)
R-HSA-195280
Reaction Name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
See in Reactome
R-HSA-195283
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195283
Reaction Name: Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
See in Reactome
R-HSA-195287
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195287
Reaction Name: Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
See in Reactome
R-HSA-195300
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195300
Reaction Name: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
See in Reactome
R-HSA-195304
(
R-HSA-195253
)
R-HSA-195304
Reaction Name: Association of beta-catenin with the destruction complex
See in Reactome
R-HSA-195318
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195318
Reaction Name: Phosphorylation of beta-catenin at Ser45 by CK1 alpha
See in Reactome
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-201685
(
R-HSA-4641262
)
R-HSA-201685
Reaction Name: Beta-catenin is released from the destruction complex
See in Reactome
R-HSA-201790
(
R-HSA-180024
)
R-HSA-201790
Reaction Name: DARPP-32 is dephosphorylated on Thr75 by PP2A
See in Reactome
R-HSA-2130279
(
R-HSA-195253
)
R-HSA-2130279
Reaction Name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-2130286
(
R-HSA-195253
)
R-HSA-2130286
Reaction Name: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
See in Reactome
R-HSA-2430552
(
R-HSA-2465910
)
R-HSA-2430552
Reaction Name: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2995388
(
R-HSA-2995383
)
R-HSA-3601585
(
R-HSA-4641262
)
R-HSA-3601585
Reaction Name: PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex
See in Reactome
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-388809
(
R-HSA-389513
)
R-HSA-388833
(
R-HSA-389513
)
R-HSA-389532
(
R-HSA-389513
)
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-4088141
(
R-HSA-69273
)
R-HSA-4088141
Reaction Name: PP2A-PPP2R2A dephosphorylates FOXM1
See in Reactome
R-HSA-432143
(
R-HSA-432142
)
R-HSA-5229343
(
R-HSA-195253
)
R-HSA-5229343
Reaction Name: AXIN is phosphorylated in the destruction complex
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-5672957
(
R-HSA-5673000
)
R-HSA-5672961
(
R-HSA-5673000
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5675431
(
R-HSA-5675221
)
R-HSA-6792863
(
R-HSA-6804757
)
R-HSA-6792863
Reaction Name: PP2A-PP2R5C dephosphorylates MDM2
See in Reactome
R-HSA-6792871
(
R-HSA-6804757
)
R-HSA-6792871
Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2
See in Reactome
R-HSA-6811454
(
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-6811504
(
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8856945
(
R-HSA-69273
)
R-HSA-8856951
(
R-HSA-69273
)
R-HSA-8857925
(
R-HSA-199418;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-927813
(
R-HSA-975957
)
R-HSA-927813
Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
See in Reactome
R-HSA-927830
(
R-HSA-975957
)
R-HSA-927830
Reaction Name: Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
See in Reactome
R-HSA-927836
(
R-HSA-975957
)
R-HSA-927836
Reaction Name: SMG6 hydrolyzes mRNA with premature termination codon
See in Reactome
R-HSA-934559
(
R-HSA-1295596
)
R-HSA-934559
Reaction Name: SPRY2 is phosphorylated by phosphorylated MNK1
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
R-HSA-9667965
(
R-HSA-2995383
)
|
MONDO:0044318 |
PPM1D |
O15297 |
3.1.3.16
|
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
|
R-HSA-212436
R-HSA-74160
R-HSA-73857
|
Gene expression (Transcription)
|
R-HSA-9008822
(
R-HSA-8878166
)
|
MONDO:0044638 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044704 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044705 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044740 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0054588 |
PPP1CB |
P62140 |
3.1.3.16
3.1.3.53
|
R-HSA-400253
R-HSA-5625900
R-HSA-5625740
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-163560
R-HSA-5627117
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-5673000
R-HSA-5627123
|
R-HSA-195258
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-194315
R-HSA-453274
R-HSA-556833
R-HSA-69278
R-HSA-1430728
R-HSA-162582
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-8979227
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-5684996
R-HSA-69275
R-HSA-5673001
|
Circadian Clock
Metabolism
Signal Transduction
Cell Cycle
|
R-HSA-163568
(
R-HSA-163560
)
R-HSA-163568
Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate
See in Reactome
R-HSA-178178
(
R-HSA-2173788
)
R-HSA-178189
(
R-HSA-2173788
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-3002811
(
R-HSA-2565942
)
R-HSA-3002811
Reaction Name: Myosin phosphatase dephosphorylates PLK1
See in Reactome
R-HSA-400382
(
R-HSA-400253
)
R-HSA-400382
Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins
See in Reactome
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419232
(
R-HSA-5625740;
R-HSA-5627117;
R-HSA-5627123
)
R-HSA-419232
Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain
See in Reactome
R-HSA-5668947
(
R-HSA-5627123
)
R-HSA-5668947
Reaction Name: PAK1 phosphorylates myosin phosphatase
See in Reactome
R-HSA-5668978
(
R-HSA-5627123
)
R-HSA-5668978
Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
See in Reactome
R-HSA-5671772
(
R-HSA-5625740
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-9658445
(
R-HSA-5673000
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|