DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.1.5)

Number of enzymes:	5
Number of disease:	16
Number of reactomes:	17
Number of reactions:	28

Search results (EC number: 3.1.1.5)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000437	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0001149	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0008935	PNPLA6	Q8IY17	3.1.1.5	R-HSA-6814848 R-HSA-6814848 Reactome Name: Glycerophospholipid catabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-6814254 ( R-HSA-6814848 ) R-HSA-6814254 Reaction Name: PNPLA6 hydrolyzes LysoPtdCho See in Reactome
MONDO:0008939	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0008980	PNPLA6	Q8IY17	3.1.1.5	R-HSA-6814848 R-HSA-6814848 Reactome Name: Glycerophospholipid catabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-6814254 ( R-HSA-6814848 ) R-HSA-6814254 Reaction Name: PNPLA6 hydrolyzes LysoPtdCho See in Reactome
MONDO:0009514	PNPLA6	Q8IY17	3.1.1.5	R-HSA-6814848 R-HSA-6814848 Reactome Name: Glycerophospholipid catabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-6814254 ( R-HSA-6814848 ) R-HSA-6814254 Reaction Name: PNPLA6 hydrolyzes LysoPtdCho See in Reactome
MONDO:0010152	PNPLA6	Q8IY17	3.1.1.5	R-HSA-6814848 R-HSA-6814848 Reactome Name: Glycerophospholipid catabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-6814254 ( R-HSA-6814848 ) R-HSA-6814254 Reaction Name: PNPLA6 hydrolyzes LysoPtdCho See in Reactome
MONDO:0012444	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0012787	PNPLA6	Q8IY17	3.1.1.5	R-HSA-6814848 R-HSA-6814848 Reactome Name: Glycerophospholipid catabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-6814254 ( R-HSA-6814848 ) R-HSA-6814254 Reaction Name: PNPLA6 hydrolyzes LysoPtdCho See in Reactome
MONDO:0013060	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0013533	LIPC	P11150	3.1.1.5 3.1.1.32 3.1.1.3	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8964026 R-HSA-8964026 Reactome Name: Chylomicron clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome	Transport of small molecules	R-HSA-174657 ( R-HSA-8964026 ) R-HSA-174657 Reaction Name: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex See in Reactome R-HSA-5694109 ( R-HSA-8963889 ) R-HSA-5694109 Reaction Name: LIPC dimer hydrolyses TAG to DAG and FA See in Reactome R-HSA-6785178 ( R-HSA-8963889 ) R-HSA-6785178 Reaction Name: LMF1,2 transport LIPC dimer from ER lumen to extracellular region See in Reactome R-HSA-6785181 ( R-HSA-8963889 ) R-HSA-6785181 Reaction Name: LMF1,2 bind LIPC dimer See in Reactome R-HSA-6785213 ( R-HSA-8963889 ) R-HSA-6785213 Reaction Name: LIPC dimer binds heparin See in Reactome
MONDO:0016392	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0016825	PNPLA8	Q9NP80	3.1.1.- 3.1.1.5	R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome	Metabolism	R-HSA-1482816 ( R-HSA-1482788 ) R-HSA-1482816 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[6] See in Reactome R-HSA-1482887 ( R-HSA-1482839 ) R-HSA-1482887 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[3] See in Reactome
MONDO:0018765	PLA2G4A	P47712	3.1.1.4 3.1.1.5	R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-1483166 R-HSA-1483166 Reactome Name: Synthesis of PA See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482801 R-HSA-1482801 Reactome Name: Acyl chain remodelling of PS See in Reactome R-HSA-1482925 R-HSA-1482925 Reactome Name: Acyl chain remodelling of PG See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-1482922 R-HSA-1482922 Reactome Name: Acyl chain remodelling of PI See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome R-HSA-1483115 R-HSA-1483115 Reactome Name: Hydrolysis of LPC See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Hemostasis Signal Transduction Vesicle-mediated transport	R-HSA-111881 ( R-HSA-111995 ) R-HSA-111881 Reaction Name: Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase See in Reactome R-HSA-111883 ( R-HSA-111995; R-HSA-2142753 ) R-HSA-111883 Reaction Name: Hydrolysis of phosphatidylcholine See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1482604 ( R-HSA-1483166 ) R-HSA-1482604 Reaction Name: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) See in Reactome R-HSA-1482612 ( R-HSA-1483115 ) R-HSA-1482612 Reaction Name: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] See in Reactome R-HSA-1482656 ( R-HSA-1483166 ) R-HSA-1482656 Reaction Name: PA is hydrolysed to 1-acyl LPA by PLA2[1] See in Reactome R-HSA-1482685 ( R-HSA-1483115 ) R-HSA-1482685 Reaction Name: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] See in Reactome R-HSA-1482759 ( R-HSA-1482798 ) R-HSA-1482759 Reaction Name: MLCL is hydrolyzed to DLCL by PLA2G4A (IM) See in Reactome R-HSA-1482771 ( R-HSA-1482801 ) R-HSA-1482771 Reaction Name: PS is hydrolyzed to 1-acyl LPS by PLA2[9] See in Reactome R-HSA-1482825 ( R-HSA-1482922 ) R-HSA-1482825 Reaction Name: PI is hydrolyzed to 1-acyl LPI by PLA2[11] See in Reactome R-HSA-1482828 ( R-HSA-1482839 ) R-HSA-1482828 Reaction Name: PE is hydrolyzed to 2-acyl LPE by PLA2[4] See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482862 ( R-HSA-1482788 ) R-HSA-1482862 Reaction Name: PC is hydrolysed to 2-acyl LPC by PLA2[7] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-1482897 ( R-HSA-1482801 ) R-HSA-1482897 Reaction Name: PS is hydrolyzed to 2-acyl LPS by PLA2[10] See in Reactome R-HSA-1482900 ( R-HSA-1482925 ) R-HSA-1482900 Reaction Name: PG is hydrolyzed to 1-acyl LPG by PLA2[1] See in Reactome R-HSA-428961 ( R-HSA-418592; R-HSA-432142 ) R-HSA-428961 Reaction Name: Phosphorylation of cPLA2 by MAPK p38 alpha See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0018794	PLA2G4A	P47712	3.1.1.4 3.1.1.5	R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-1483166 R-HSA-1483166 Reactome Name: Synthesis of PA See in Reactome R-HSA-418592 R-HSA-418592 Reactome Name: ADP signalling through P2Y purinoceptor 1 See in Reactome R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482801 R-HSA-1482801 Reactome Name: Acyl chain remodelling of PS See in Reactome R-HSA-1482925 R-HSA-1482925 Reactome Name: Acyl chain remodelling of PG See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-1482922 R-HSA-1482922 Reactome Name: Acyl chain remodelling of PI See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome R-HSA-1483115 R-HSA-1483115 Reactome Name: Hydrolysis of LPC See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-392518 R-HSA-392518 Reactome Name: Signal amplification See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Hemostasis Signal Transduction Vesicle-mediated transport	R-HSA-111881 ( R-HSA-111995 ) R-HSA-111881 Reaction Name: Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase See in Reactome R-HSA-111883 ( R-HSA-111995; R-HSA-2142753 ) R-HSA-111883 Reaction Name: Hydrolysis of phosphatidylcholine See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1482604 ( R-HSA-1483166 ) R-HSA-1482604 Reaction Name: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) See in Reactome R-HSA-1482612 ( R-HSA-1483115 ) R-HSA-1482612 Reaction Name: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] See in Reactome R-HSA-1482656 ( R-HSA-1483166 ) R-HSA-1482656 Reaction Name: PA is hydrolysed to 1-acyl LPA by PLA2[1] See in Reactome R-HSA-1482685 ( R-HSA-1483115 ) R-HSA-1482685 Reaction Name: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] See in Reactome R-HSA-1482759 ( R-HSA-1482798 ) R-HSA-1482759 Reaction Name: MLCL is hydrolyzed to DLCL by PLA2G4A (IM) See in Reactome R-HSA-1482771 ( R-HSA-1482801 ) R-HSA-1482771 Reaction Name: PS is hydrolyzed to 1-acyl LPS by PLA2[9] See in Reactome R-HSA-1482825 ( R-HSA-1482922 ) R-HSA-1482825 Reaction Name: PI is hydrolyzed to 1-acyl LPI by PLA2[11] See in Reactome R-HSA-1482828 ( R-HSA-1482839 ) R-HSA-1482828 Reaction Name: PE is hydrolyzed to 2-acyl LPE by PLA2[4] See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482862 ( R-HSA-1482788 ) R-HSA-1482862 Reaction Name: PC is hydrolysed to 2-acyl LPC by PLA2[7] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-1482897 ( R-HSA-1482801 ) R-HSA-1482897 Reaction Name: PS is hydrolyzed to 2-acyl LPS by PLA2[10] See in Reactome R-HSA-1482900 ( R-HSA-1482925 ) R-HSA-1482900 Reaction Name: PG is hydrolyzed to 1-acyl LPG by PLA2[1] See in Reactome R-HSA-428961 ( R-HSA-418592; R-HSA-432142 ) R-HSA-428961 Reaction Name: Phosphorylation of cPLA2 by MAPK p38 alpha See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0024457	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome