DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.1.32)

Number of enzymes:	2
Number of disease:	3
Number of reactomes:	5
Number of reactions:	12

Search results (EC number: 3.1.1.32)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007759	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0009387	LPL	P06858	3.1.1.34 3.1.1.32	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-8963901 R-HSA-8963901 Reactome Name: Chylomicron remodeling See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Sensory Perception Metabolism Developmental Biology	R-HSA-174757 ( R-HSA-8963901 ) R-HSA-174757 Reaction Name: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols See in Reactome R-HSA-2395768 ( R-HSA-975634 ) R-HSA-2395768 Reaction Name: LPL hydrolyses TGs from mature CMs See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-6784628 ( R-HSA-8963889 ) R-HSA-6784628 Reaction Name: PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784676 ( R-HSA-8963889 ) R-HSA-6784676 Reaction Name: PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer See in Reactome R-HSA-6784861 ( R-HSA-8963889 ) R-HSA-6784861 Reaction Name: HSPG binds LPL dimer See in Reactome R-HSA-8857928 ( R-HSA-8963889 ) R-HSA-8857928 Reaction Name: GPIHBP1 binds HSPG:LPL dimer See in Reactome
MONDO:0013533	LIPC	P11150	3.1.1.5 3.1.1.32 3.1.1.3	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8964026 R-HSA-8964026 Reactome Name: Chylomicron clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome	Transport of small molecules	R-HSA-174657 ( R-HSA-8964026 ) R-HSA-174657 Reaction Name: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex See in Reactome R-HSA-5694109 ( R-HSA-8963889 ) R-HSA-5694109 Reaction Name: LIPC dimer hydrolyses TAG to DAG and FA See in Reactome R-HSA-6785178 ( R-HSA-8963889 ) R-HSA-6785178 Reaction Name: LMF1,2 transport LIPC dimer from ER lumen to extracellular region See in Reactome R-HSA-6785181 ( R-HSA-8963889 ) R-HSA-6785181 Reaction Name: LMF1,2 bind LIPC dimer See in Reactome R-HSA-6785213 ( R-HSA-8963889 ) R-HSA-6785213 Reaction Name: LIPC dimer binds heparin See in Reactome