DAR - Bologna Biocomputing Group

Search summary (EC number: 3.1.1.3)

Number of enzymes:	5
Number of disease:	5
Number of reactomes:	7
Number of reactions:	17

Search results (EC number: 3.1.1.3)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0012348	CEL	P19835	3.1.1.6 3.1.1.13 3.1.1.3	R-HSA-192456 R-HSA-192456 Reactome Name: Digestion of dietary lipid See in Reactome	R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	Digestion and absorption	R-HSA-192417 ( R-HSA-192456 ) R-HSA-192417 Reaction Name: Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) See in Reactome R-HSA-192425 ( R-HSA-192456 ) R-HSA-192425 Reaction Name: Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) See in Reactome R-HSA-192430 ( R-HSA-192456 ) R-HSA-192430 Reaction Name: Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) See in Reactome
MONDO:0012545	PNPLA2	Q96AD5	3.1.1.3	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-1482883 R-HSA-1482883 Reactome Name: Acyl chain remodeling of DAG and TAG See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1482647 ( R-HSA-1482883 ) R-HSA-1482647 Reaction Name: 2-MAG and DAG are transacylated to TAG by PNPLA2/3 See in Reactome R-HSA-1482654 ( R-HSA-1482883 ) R-HSA-1482654 Reaction Name: 2-MAG is transacylated to DAG by PNPLA2/3 See in Reactome R-HSA-1482777 ( R-HSA-1482883 ) R-HSA-1482777 Reaction Name: TAG is hydrolyzed to DAG by PNPLA2/3 See in Reactome R-HSA-1482811 ( R-HSA-1482883 ) R-HSA-1482811 Reaction Name: DAG is hydrolyzed to 2-MAG by PNPLA2/3 See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0013533	LIPC	P11150	3.1.1.5 3.1.1.32 3.1.1.3	R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8964026 R-HSA-8964026 Reactome Name: Chylomicron clearance See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome	Transport of small molecules	R-HSA-174657 ( R-HSA-8964026 ) R-HSA-174657 Reaction Name: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex See in Reactome R-HSA-5694109 ( R-HSA-8963889 ) R-HSA-5694109 Reaction Name: LIPC dimer hydrolyses TAG to DAG and FA See in Reactome R-HSA-6785178 ( R-HSA-8963889 ) R-HSA-6785178 Reaction Name: LMF1,2 transport LIPC dimer from ER lumen to extracellular region See in Reactome R-HSA-6785181 ( R-HSA-8963889 ) R-HSA-6785181 Reaction Name: LMF1,2 bind LIPC dimer See in Reactome R-HSA-6785213 ( R-HSA-8963889 ) R-HSA-6785213 Reaction Name: LIPC dimer binds heparin See in Reactome
MONDO:0013700	PNLIP	P16233	3.1.1.3	R-HSA-192456 R-HSA-192456 Reactome Name: Digestion of dietary lipid See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome	R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8935690 R-HSA-8935690 Reactome Name: Digestion See in Reactome	Sensory Perception Digestion and absorption Metabolism	R-HSA-192422 ( R-HSA-192456 ) R-HSA-192422 Reaction Name: Digestion of triacylglycerols by extracellular PTL:colipase See in Reactome R-HSA-192434 ( R-HSA-192456 ) R-HSA-192434 Reaction Name: Digestion of diacylglycerols by extracellular PTL:colipase See in Reactome R-HSA-192475 ( R-HSA-192456 ) R-HSA-192475 Reaction Name: Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 See in Reactome R-HSA-975593 ( R-HSA-192456; R-HSA-975634 ) R-HSA-975593 Reaction Name: PNLIP:CLPS hydrolyses RPALM to atROL and PALM See in Reactome
MONDO:0021105	PNPLA3	Q9NST1	2.3.1.51 3.1.1.3	R-HSA-1482883 R-HSA-1482883 Reactome Name: Acyl chain remodeling of DAG and TAG See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome	Metabolism	R-HSA-1482647 ( R-HSA-1482883 ) R-HSA-1482647 Reaction Name: 2-MAG and DAG are transacylated to TAG by PNPLA2/3 See in Reactome R-HSA-1482654 ( R-HSA-1482883 ) R-HSA-1482654 Reaction Name: 2-MAG is transacylated to DAG by PNPLA2/3 See in Reactome R-HSA-1482777 ( R-HSA-1482883 ) R-HSA-1482777 Reaction Name: TAG is hydrolyzed to DAG by PNPLA2/3 See in Reactome R-HSA-1482811 ( R-HSA-1482883 ) R-HSA-1482811 Reaction Name: DAG is hydrolyzed to 2-MAG by PNPLA2/3 See in Reactome