DAR - Bologna Biocomputing Group

Search results (EC number: 2.7.11.30)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002049	ACVRL1	P37023	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8858369 ( R-HSA-201451 ) R-HSA-8858369 Reaction Name: ACVRL1 binds BMP9,BMP10 See in Reactome
MONDO:0002911	ACVR1	Q04771	2.7.11.30
MONDO:0005036	ACVR1	Q04771	2.7.11.30
MONDO:0005580	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0007216	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0007522	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007566	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007606	ACVR1	Q04771	2.7.11.30
MONDO:0007606	BMPR2	Q13873	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0007947	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007947	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0008276	BMPR1A	P36894	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0008703	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0008717	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0009231	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0009857	AMHR2	Q16671	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8858346 ( R-HSA-201451 ) R-HSA-8858346 Reaction Name: AMHR2 binds AMH See in Reactome
MONDO:0010880	ACVRL1	P37023	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8858369 ( R-HSA-201451 ) R-HSA-8858369 Reaction Name: ACVRL1 binds BMP9,BMP10 See in Reactome
MONDO:0012212	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0012212	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0012274	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0012405	BMPR1A	P36894	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0012427	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0013403	ACVR2B	Q13705	2.7.11.30	R-HSA-1433617 R-HSA-1433617 Reactome Name: Regulation of signaling by NODAL See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1181149 ( R-HSA-1502540 ) R-HSA-1181149 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin See in Reactome R-HSA-1181153 ( R-HSA-1502540 ) R-HSA-1181153 Reaction Name: Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B See in Reactome R-HSA-1181155 ( R-HSA-1181150 ) R-HSA-1181155 Reaction Name: The NODAL Receptor binds NODAL ligands See in Reactome R-HSA-1181156 ( R-HSA-1181150 ) R-HSA-1181156 Reaction Name: Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL See in Reactome R-HSA-1181351 ( R-HSA-1181150; R-HSA-1433617 ) R-HSA-1181351 Reaction Name: LEFTY binds the EGF-CFC coreceptor in the NODAL receptor See in Reactome R-HSA-1181355 ( R-HSA-1181150 ) R-HSA-1181355 Reaction Name: Phosphorylation of R-SMAD2/3 by NODAL receptor See in Reactome R-HSA-1225894 ( R-HSA-1181150 ) R-HSA-1225894 Reaction Name: Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL See in Reactome R-HSA-1549526 ( R-HSA-1502540 ) R-HSA-1549526 Reaction Name: Phosphorylation of SMAD2,3 by Activin:Activin Receptor See in Reactome R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome R-HSA-2470483 ( R-HSA-1502540 ) R-HSA-2470483 Reaction Name: Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C See in Reactome R-HSA-2470508 ( R-HSA-1502540 ) R-HSA-2470508 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin See in Reactome
MONDO:0013695	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0014798	BMPR1B	O00238	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0017152	BMPR2	Q13873	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0019625	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0019625	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0020713	BMPR2	Q13873	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome
MONDO:0024533	ACVRL1	P37023	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8858369 ( R-HSA-201451 ) R-HSA-8858369 Reaction Name: ACVRL1 binds BMP9,BMP10 See in Reactome
MONDO:0024533	BMPR2	Q13873	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome

Number of enzymes:	9
Number of disease:	26
Number of reactomes:	9
Number of reactions:	46

Search summary (EC number: 2.7.11.30)

Search results (EC number: 2.7.11.30)

MONDO:0002049

R-HSA-201451

R-HSA-9006936

R-HSA-162582

R-HSA-8858369

MONDO:0002911

MONDO:0005036

MONDO:0005580

R-HSA-2173791

R-HSA-5689603

R-HSA-2173789

R-HSA-2173788

R-HSA-170834

R-HSA-5688426

R-HSA-392499

R-HSA-9006936

R-HSA-597592

R-HSA-162582

R-HSA-170835

R-HSA-170843

R-HSA-170846

R-HSA-170850

R-HSA-170861

R-HSA-170868

R-HSA-173483

R-HSA-173512

R-HSA-178178

R-HSA-178189

R-HSA-178218

R-HSA-2127562

R-HSA-2128994

R-HSA-2134519

R-HSA-2134532

R-HSA-2160931

R-HSA-2160932

R-HSA-2160935

R-HSA-2169046

R-HSA-2169050

R-HSA-2179291

R-HSA-2179293

R-HSA-4332235

R-HSA-4332236

MONDO:0007216

R-HSA-201451

R-HSA-9006936

R-HSA-162582

R-HSA-201443

R-HSA-201453

R-HSA-201457

R-HSA-201475

R-HSA-201476

R-HSA-201648

R-HSA-201821

R-HSA-202604

MONDO:0007522

R-HSA-2173791

R-HSA-5689880

R-HSA-5689603

R-HSA-2173789

R-HSA-2173788

R-HSA-170834

R-HSA-5688426

R-HSA-392499

R-HSA-9006936

R-HSA-597592

R-HSA-162582

R-HSA-170835

R-HSA-170843

R-HSA-170846

R-HSA-170850

R-HSA-170868

R-HSA-173483

R-HSA-173512

R-HSA-178178

R-HSA-178189

R-HSA-178218

R-HSA-2127562

R-HSA-2128994