MONDO:0007648 |
MAP3K6 |
O95382 |
2.7.11.25
|
|
|
|
|
MONDO:0008005 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0008464 |
MAP3K20 |
Q9NYL2 |
2.7.11.25
|
|
|
|
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
MAP3K8 |
P41279 |
2.7.11.25
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1280218
R-HSA-9020702
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-389356
R-HSA-166166
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-446652
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
|
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-392530
(
R-HSA-389357
)
R-HSA-451634
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-451634
Reaction Name: NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
See in Reactome
R-HSA-451649
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684248
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684248
Reaction Name: SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
See in Reactome
R-HSA-5684250
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684250
Reaction Name: SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
See in Reactome
R-HSA-5684261
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684273
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684273
Reaction Name: 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
|
MONDO:0009711 |
MAP3K20 |
Q9NYL2 |
2.7.11.25
|
|
|
|
|
MONDO:0013410 |
MAP3K1 |
Q13233 |
2.7.11.25
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
|
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-168898
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
|
R-HSA-166869
(
R-HSA-166058;
R-HSA-975138;
R-HSA-975871
)
R-HSA-2730868
(
R-HSA-2871796
)
R-HSA-2730868
Reaction Name: Phosphorylation of MEK7 by MEKK1
See in Reactome
R-HSA-2730887
(
R-HSA-2871796
)
R-HSA-2730887
Reaction Name: Autophosphorylation and activation of MEKK1
See in Reactome
R-HSA-2730896
(
R-HSA-2871796
)
R-HSA-2730896
Reaction Name: Phosphorylation of MEK4 by MEKK1
See in Reactome
R-HSA-933528
(
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
|
MONDO:0014816 |
MAP3K20 |
Q9NYL2 |
2.7.11.25
|
|
|
|
|
MONDO:0014935 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
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Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0018642 |
MAP3K14 |
Q99558 |
2.7.11.25
|
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-5676594
R-HSA-5676594
Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5607764
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
|
Immune System
|
R-HSA-392530
(
R-HSA-389357
)
R-HSA-5607720
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607720
Reaction Name: p100:RELB binds active NIK:p-IKKA dimer
See in Reactome
R-HSA-5607721
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607722
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607722
Reaction Name: Active NIK phosphorylates IKKA dimer
See in Reactome
R-HSA-5607723
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607723
Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
See in Reactome
R-HSA-5607725
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607725
Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
See in Reactome
R-HSA-5607726
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607726
Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
See in Reactome
R-HSA-5668414
(
R-HSA-5668541
)
R-HSA-5668414
Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
See in Reactome
R-HSA-5668417
(
R-HSA-5668541
)
R-HSA-5668417
Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
See in Reactome
R-HSA-5668454
(
R-HSA-5668541
)
R-HSA-5668454
Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3
See in Reactome
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5668534
(
R-HSA-5668541
)
R-HSA-5668534
Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
See in Reactome
R-HSA-5668543
(
R-HSA-5668541
)
R-HSA-5668545
(
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5668545
Reaction Name: NIK autophosphorylates on T559
See in Reactome
R-HSA-5676593
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676593
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
See in Reactome
R-HSA-5676595
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676596
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
See in Reactome
R-HSA-5676598
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676598
Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK
See in Reactome
|
MONDO:0054695 |
MAP3K20 |
Q9NYL2 |
2.7.11.25
|
|
|
|
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