DAR - Bologna Biocomputing Group

Search summary (EC number: 2.7.11.23)

Number of enzymes:	3
Number of disease:	3
Number of reactomes:	7
Number of reactions:	22

Search results (EC number: 2.7.11.23)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005061	CDK12	Q9NYV4	2.7.11.22 2.7.11.23	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription)	R-HSA-6797090 ( R-HSA-212436; R-HSA-6796648 ) R-HSA-6797090 Reaction Name: CCNK binds CDK12 See in Reactome R-HSA-6797606 ( R-HSA-212436; R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-212436; R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-212436; R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome
MONDO:0032897	CDK8	P49336	2.7.11.22 2.7.11.23	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism Signal Transduction Developmental Biology	R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-212352 ( R-HSA-212436 ) R-HSA-212352 Reaction Name: Formation of ARC coactivator complex See in Reactome R-HSA-212380 ( R-HSA-212436 ) R-HSA-212380 Reaction Name: Formation of TRAP coactivator complex See in Reactome R-HSA-212432 ( R-HSA-212436 ) R-HSA-212432 Reaction Name: Formation of DRIP coactivator complex See in Reactome R-HSA-2176475 ( R-HSA-212436; R-HSA-2173796 ) R-HSA-2176475 Reaction Name: Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome
MONDO:0044302	CDK13	Q14004	2.7.11.22 2.7.11.23	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Immune System Gene expression (Transcription)	R-HSA-6797100 ( R-HSA-6796648 ) R-HSA-6797100 Reaction Name: CCNK binds CDK13 See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome