MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0014873 |
NEK9 |
Q8TD19 |
2.7.11.1
|
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-2980767
R-HSA-2980767
Reactome Name: Activation of NIMA Kinases NEK9, NEK6, NEK7
See in Reactome
R-HSA-3301854
R-HSA-3301854
Reactome Name: Nuclear Pore Complex (NPC) Disassembly
See in Reactome
|
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-2980766
R-HSA-68875
|
Cell Cycle
|
R-HSA-2980720
(
R-HSA-2980767
)
R-HSA-2980720
Reaction Name: NEK9 binds NEK6/NEK7 in the cytosol
See in Reactome
R-HSA-2984220
(
R-HSA-2980767
)
R-HSA-2984226
(
R-HSA-2980767
)
R-HSA-2984258
(
R-HSA-2980767
)
R-HSA-2990880
(
R-HSA-3301854
)
R-HSA-2990880
Reaction Name: NEK6/NEK7 phosphorylates NUP98
See in Reactome
R-HSA-9648017
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
Reaction Name: NEK6 and NEK7 phosphorylate EML4
See in Reactome
|
MONDO:0017939 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0054754 |
TBK1 |
Q9UHD2 |
2.7.11.1
|
R-HSA-3270619
R-HSA-3270619
Reactome Name: IRF3-mediated induction of type I IFN
See in Reactome
R-HSA-933541
R-HSA-3134975
R-HSA-3134975
Reactome Name: Regulation of innate immune responses to cytosolic DNA
See in Reactome
R-HSA-9013973
R-HSA-9013973
Reactome Name: TICAM1-dependent activation of IRF3/IRF7
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-1606341
R-HSA-1606341
Reactome Name: IRF3 mediated activation of type 1 IFN
See in Reactome
R-HSA-3249367
R-HSA-3249367
Reactome Name: STAT6-mediated induction of chemokines
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-9008059
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168898
R-HSA-449147
R-HSA-168256
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168249
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-1834941
R-HSA-1834941
Reactome Name: STING mediated induction of host immune responses
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-446652
|
Immune System
|
R-HSA-1606324
(
R-HSA-1606341
)
R-HSA-1606324
Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
See in Reactome
R-HSA-1606327
(
R-HSA-1606341
)
R-HSA-1606327
Reaction Name: Phosphorylation and release of IRF3
See in Reactome
R-HSA-1606345
(
R-HSA-1606341
)
R-HSA-1606345
Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1
See in Reactome
R-HSA-166245
(
R-HSA-936964
)
R-HSA-166245
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-1834939
(
R-HSA-3270619
)
R-HSA-2396002
(
R-HSA-3270619
)
R-HSA-2396002
Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex
See in Reactome
R-HSA-2396007
(
R-HSA-3270619
)
R-HSA-2396007
Reaction Name: IRF3 is phosphorylated by TBK1
See in Reactome
R-HSA-3249371
(
R-HSA-3249367
)
R-HSA-3249371
Reaction Name: TBK1 phosphorylates STAT6 at Ser407
See in Reactome
R-HSA-3249378
(
R-HSA-3249367
)
R-HSA-3249386
(
R-HSA-3134975
)
R-HSA-3249386
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-3249390
(
R-HSA-3249367
)
R-HSA-3249390
Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex
See in Reactome
R-HSA-3249392
(
R-HSA-3134975
)
R-HSA-3249392
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
See in Reactome
R-HSA-8948703
(
R-HSA-3134975
)
R-HSA-8948703
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-8948709
(
R-HSA-3134975
)
R-HSA-8948709
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
See in Reactome
R-HSA-9008684
(
R-HSA-9008059
)
R-HSA-9013978
(
R-HSA-9013973
)
R-HSA-9013978
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
See in Reactome
R-HSA-9013979
(
R-HSA-9013973
)
R-HSA-9013979
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
See in Reactome
R-HSA-9013986
(
R-HSA-9013973
)
R-HSA-9013986
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
See in Reactome
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-936941
(
R-HSA-936964
)
R-HSA-936941
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
See in Reactome
R-HSA-937337
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
R-HSA-9679819
(
R-HSA-1606341
)
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9709831
(
R-HSA-168928
)
R-HSA-9709852
(
R-HSA-168928
)
R-HSA-9709852
Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3
See in Reactome
|
MONDO:0008869 |
ATR |
Q13535 |
2.7.11.1
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-69473
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-6783310
R-HSA-176187
R-HSA-176187
Reactome Name: Activation of ATR in response to replication stress
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-5633007
R-HSA-69481
R-HSA-69620
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-2262752
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-1500620
R-HSA-5693538
R-HSA-1640170
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Cell Cycle
DNA Repair
Reproduction
|
R-HSA-176116
(
R-HSA-176187;
R-HSA-69473
)
R-HSA-176116
Reaction Name: Recruitment and activation of Chk1
See in Reactome
R-HSA-176250
(
R-HSA-176187
)
R-HSA-176250
Reaction Name: Binding of ATR-ATRIP to the RPA-ssDNA complex
See in Reactome
R-HSA-176298
(
R-HSA-176187
)
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693561
(
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
|
MONDO:0060671 |
CILK1 |
Q9UPZ9 |
2.7.11.1
|
|
|
|
|
MONDO:0009759 |
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0017193 |
RPS6KA3 |
P51812 |
2.7.11.1
|
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-198753
R-HSA-437239
R-HSA-199920
R-HSA-444257
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-2559583
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-2262752
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8953897
R-HSA-1266738
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-166520
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-9675108
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-373760
R-HSA-388396
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-372790
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-416476
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Cellular responses to stimuli
Developmental Biology
Neuronal System
Signal Transduction
|
R-HSA-198746
(
R-HSA-166058;
R-HSA-198753;
R-HSA-2559582;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
(
R-HSA-166058;
R-HSA-199920;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
Reaction Name: RSK1/2/3 phosphorylates CREB at Serine 133
See in Reactome
R-HSA-374696
(
R-HSA-437239
)
R-HSA-374696
Reaction Name: Phosphorylation of L1 by p90rsk
See in Reactome
R-HSA-3857328
(
R-HSA-2559582
)
R-HSA-3857328
Reaction Name: RPS6KA1/2/3 phosphorylates CEBPB on S321
See in Reactome
R-HSA-442724
(
R-HSA-442742
)
R-HSA-442724
Reaction Name: Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
See in Reactome
R-HSA-442739
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
Reaction Name: p-S363,S380,T573 RS6K translocates to the nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9620004
(
R-HSA-442742;
R-HSA-444257
)
|
MONDO:0015802 |
TAOK1 |
Q7L7X3 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0014908 |
CIT |
O14578 |
2.7.11.1
|
R-HSA-5625900
R-HSA-9013149
R-HSA-9013106
R-HSA-9013026
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671972
(
R-HSA-5625900
)
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
|
MONDO:0017884 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0000141 |
BUB1 |
O43683 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0018507 |
VRK1 |
Q99986 |
2.7.11.1
|
R-HSA-2995383
R-HSA-2995383
Reactome Name: Initiation of Nuclear Envelope (NE) Reformation
See in Reactome
R-HSA-2980766
|
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-2995410
R-HSA-2995410
Reactome Name: Nuclear Envelope (NE) Reassembly
See in Reactome
R-HSA-68875
|
Cell Cycle
|
R-HSA-2993898
(
R-HSA-2980766
)
R-HSA-2995389
(
R-HSA-2995383
)
|
MONDO:0008280 |
STK11 |
Q15831 |
2.7.11.1
|
R-HSA-163680
R-HSA-163680
Reactome Name: AMPK inhibits chREBP transcriptional activation activity
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-9614085
R-HSA-74160
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-165159
R-HSA-212436
R-HSA-1430728
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism
Signal Transduction
|
R-HSA-164151
(
R-HSA-163680
)
R-HSA-164151
Reaction Name: LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
See in Reactome
R-HSA-200421
(
R-HSA-380972
)
R-HSA-200421
Reaction Name: Activation of cytosolic AMPK by phosphorylation
See in Reactome
R-HSA-3222006
(
R-HSA-6804756
)
R-HSA-3222006
Reaction Name: STK11 (LKB1) phosphorylates NUAK1
See in Reactome
R-HSA-3222020
(
R-HSA-6804756
)
R-HSA-380942
(
R-HSA-380972
)
R-HSA-380942
Reaction Name: LKB1 forms a trimeric complex with STRAD and MO25
See in Reactome
R-HSA-6805035
(
R-HSA-6804756
)
R-HSA-9625378
(
R-HSA-9614657
)
R-HSA-9625378
Reaction Name: STK11 gene transcription is stimulated by FOXO3,FOXO4
See in Reactome
|
OMIM:619575 |
TAOK1 |
Q7L7X3 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0013611 |
MAK |
P20794 |
2.7.11.1
|
|
|
|
|
MONDO:0018823 |
TAF1 |
P21675 |
2.7.11.1
2.3.1.48
|
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-212436
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73857
R-HSA-5633007
R-HSA-74160
|
Gene expression (Transcription)
|
R-HSA-109636
(
R-HSA-73779
)
R-HSA-109636
Reaction Name: Recognition and Binding of Core Promoter Elements by TFIID
See in Reactome
R-HSA-109637
(
R-HSA-73779
)
R-HSA-109637
Reaction Name: Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex
See in Reactome
R-HSA-109638
(
R-HSA-73779
)
R-HSA-109638
Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
See in Reactome
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-6805399
(
R-HSA-6804756
)
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-75095
(
R-HSA-73779
)
R-HSA-75095
Reaction Name: Binding of TFIIE to the growing preinitiation complex
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
|
MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0000468 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0002407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008104 |
RAF1 |
P04049 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5621575
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-2672351
R-HSA-392517
R-HSA-5673000
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-168256
R-HSA-983712
R-HSA-168249
R-HSA-382551
R-HSA-1280218
R-HSA-5673001
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
|
Immune System
Transport of small molecules
Hemostasis
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-392835
(
R-HSA-392517
)
R-HSA-392835
Reaction Name: Rap1 sequesters Raf1 to inhibit ERK cascade
See in Reactome
R-HSA-443439
(
R-HSA-430116
)
R-HSA-443831
(
R-HSA-430116
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005335 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0014870 |
NEK9 |
Q8TD19 |
2.7.11.1
|
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-2980767
R-HSA-2980767
Reactome Name: Activation of NIMA Kinases NEK9, NEK6, NEK7
See in Reactome
R-HSA-3301854
R-HSA-3301854
Reactome Name: Nuclear Pore Complex (NPC) Disassembly
See in Reactome
|
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-2980766
R-HSA-68875
|
Cell Cycle
|
R-HSA-2980720
(
R-HSA-2980767
)
R-HSA-2980720
Reaction Name: NEK9 binds NEK6/NEK7 in the cytosol
See in Reactome
R-HSA-2984220
(
R-HSA-2980767
)
R-HSA-2984226
(
R-HSA-2980767
)
R-HSA-2984258
(
R-HSA-2980767
)
R-HSA-2990880
(
R-HSA-3301854
)
R-HSA-2990880
Reaction Name: NEK6/NEK7 phosphorylates NUP98
See in Reactome
R-HSA-9648017
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
Reaction Name: NEK6 and NEK7 phosphorylate EML4
See in Reactome
|
MONDO:0009696 |
CILK1 |
Q9UPZ9 |
2.7.11.1
|
|
|
|
|
MONDO:0018466 |
LRRK2 |
Q5S007 |
3.6.5.-
2.7.11.1
|
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
|
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-8848021
R-HSA-162582
|
Signal Transduction
|
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
|
MONDO:0013379 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0017564 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0010150 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0008840 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0020492 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0007154 |
MAP4K4 |
O95819 |
2.7.11.1
|
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
|
R-HSA-8953897
R-HSA-2262752
R-HSA-2559583
|
Cellular responses to stimuli
|
R-HSA-3225851
(
R-HSA-2559580
)
R-HSA-3225851
Reaction Name: ROS oxidize thioredoxin and activate MAP3K5
See in Reactome
R-HSA-3225867
(
R-HSA-2559580
)
R-HSA-3225867
Reaction Name: Expression of MINK1/TNIK is positively regulated by ROS
See in Reactome
|
MONDO:0013444 |
NEK8 |
Q86SG6 |
2.7.11.1
|
|
|
|
|
MONDO:0054837 |
TLK2 |
Q86UE8 |
2.7.11.1
|
|
|
|
|
MONDO:0011190 |
NEK8 |
Q86SG6 |
2.7.11.1
|
|
|
|
|
MONDO:0005012 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0020492 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0013125 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0010361 |
PAK3 |
O75914 |
2.7.11.1
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-428540
R-HSA-3928664
R-HSA-5687128
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-5621575
R-HSA-9013420
R-HSA-9013409
R-HSA-389359
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-9013148
R-HSA-9013149
R-HSA-5627123
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-1280218
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-202403
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-2682334
R-HSA-195258
R-HSA-373755
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Developmental Biology
Signal Transduction
|
R-HSA-389788
(
R-HSA-388841;
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-428531
(
R-HSA-428540
)
R-HSA-430183
(
R-HSA-202433
)
R-HSA-442832
(
R-HSA-5627123
)
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
Reaction Name: PAK1-3 phosphorylates VE-cadherin
See in Reactome
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5687086
(
R-HSA-5687128
)
R-HSA-5687086
Reaction Name: PAK1,2,3 phosphorylates MAPK6,4
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
|
MONDO:0014174 |
NEK8 |
Q86SG6 |
2.7.11.1
|
|
|
|
|
MONDO:0015461 |
CILK1 |
Q9UPZ9 |
2.7.11.1
|
|
|
|
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0018266 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
BUB1 |
O43683 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0008104 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0016996 |
AURKB |
Q96GD4 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-194315
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-5633007
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-69620
R-HSA-69278
R-HSA-2990846
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-68882
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-195258
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Gene expression (Transcription)
Metabolism of proteins
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174088
(
R-HSA-174178
)
R-HSA-174088
Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174195
(
R-HSA-174178
)
R-HSA-174195
Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-4655355
(
R-HSA-4615885
)
R-HSA-4655355
Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-6805122
(
R-HSA-6804756
)
R-HSA-6805126
(
R-HSA-6804756
)
R-HSA-9023132
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-9023132
Reaction Name: AURKB phosphorylates MECP2 at S423
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0054838 |
ALPK3 |
Q96L96 |
2.7.11.1
|
|
|
|
|
MONDO:0000087 |
MONDO:0000087
Disease Name: polymicrogyria
Orphanet id: Orphanet:35981
All associated enzymes in DAR:
AKT3
. The disease is also associated to other non-enzyme proteins (not in DAR).
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0017177 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0024309 |
WNK1 |
Q9H4A3 |
2.7.11.1
|
R-HSA-2672351
|
R-HSA-983712
R-HSA-382551
|
Transport of small molecules
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
|
MONDO:0009642 |
NEK1 |
Q96PY6 |
2.7.11.1
|
|
|
|
|
MONDO:0011176 |
TRPM7 |
Q96QT4 |
2.7.11.1
|
R-HSA-3295583
|
R-HSA-983712
R-HSA-382551
R-HSA-2672351
|
Transport of small molecules
|
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
|
MONDO:0010108 |
STK10 |
O94804 |
2.7.11.1
|
R-HSA-6798695
R-HSA-9013106
R-HSA-9013026
R-HSA-8980692
|
R-HSA-9012999
R-HSA-168256
R-HSA-168249
R-HSA-194315
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0023122 |
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0054750 |
NEK1 |
Q96PY6 |
2.7.11.1
|
|
|
|
|
MONDO:0032599 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-166058;
R-HSA-168928;
R-HSA-1810476;
R-HSA-1834949;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476;
R-HSA-1834949
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-209087
(
R-HSA-9020702
)
R-HSA-209087
Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-166058;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5684267
(
R-HSA-166058;
R-HSA-5684264;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-166058;
R-HSA-5684264;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0012691 |
RAF1 |
P04049 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5621575
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-2672351
R-HSA-392517
R-HSA-5673000
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-168256
R-HSA-983712
R-HSA-168249
R-HSA-382551
R-HSA-1280218
R-HSA-5673001
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
|
Immune System
Transport of small molecules
Hemostasis
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-392835
(
R-HSA-392517
)
R-HSA-392835
Reaction Name: Rap1 sequesters Raf1 to inhibit ERK cascade
See in Reactome
R-HSA-443439
(
R-HSA-430116
)
R-HSA-443831
(
R-HSA-430116
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0014893 |
CSNK2A1 |
P68400 |
2.7.11.1
|
R-HSA-445144
R-HSA-1483191
R-HSA-6814122
R-HSA-6814122
Reactome Name: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
See in Reactome
R-HSA-8939243
R-HSA-8939243
Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-201688
R-HSA-2514853
R-HSA-2514853
Reactome Name: Condensation of Prometaphase Chromosomes
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-8934903
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-1640170
R-HSA-373760
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-69278
R-HSA-390466
R-HSA-390466
Reactome Name: Chaperonin-mediated protein folding
See in Reactome
R-HSA-556833
R-HSA-9612973
R-HSA-9663891
R-HSA-392499
R-HSA-68886
R-HSA-5205647
R-HSA-1632852
R-HSA-195721
R-HSA-391251
R-HSA-6807070
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-1483257
R-HSA-422475
R-HSA-68877
R-HSA-162582
|
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Autophagy
Metabolism of proteins
Signal Transduction
|
R-HSA-201717
(
R-HSA-201688
)
R-HSA-201717
Reaction Name: CSNK2-mediated phosphorylation of DVL
See in Reactome
R-HSA-2529020
(
R-HSA-2514853;
R-HSA-68877
)
R-HSA-2529020
Reaction Name: CK2 phosphorylates condensin I subunits
See in Reactome
R-HSA-392752
(
R-HSA-445144
)
R-HSA-6805059
(
R-HSA-6804756
)
R-HSA-6805061
(
R-HSA-6804756
)
R-HSA-6814409
(
R-HSA-6814122
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8873929
(
R-HSA-1483191
)
R-HSA-8873929
Reaction Name: Casein kinase II phosphorylates STARD10
See in Reactome
R-HSA-8932322
()
R-HSA-8937989
(
R-HSA-8939243
)
R-HSA-8948039
(
R-HSA-1632852;
R-HSA-8934903
)
R-HSA-8948039
Reaction Name: FUNDC1 is phosphorylated by CK2
See in Reactome
|
MONDO:0008056 |
DMPK |
Q09013 |
2.7.11.1
|
R-HSA-5578775
|
R-HSA-397014
R-HSA-5576891
|
Muscle contraction
|
R-HSA-5578777
(
R-HSA-5578775
)
|
MONDO:0011240 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0017402 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0015372 |
TRPM7 |
Q96QT4 |
2.7.11.1
|
R-HSA-3295583
|
R-HSA-983712
R-HSA-382551
R-HSA-2672351
|
Transport of small molecules
|
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
|
MONDO:0010747 |
TAF1 |
P21675 |
2.7.11.1
2.3.1.48
|
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-212436
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73857
R-HSA-5633007
R-HSA-74160
|
Gene expression (Transcription)
|
R-HSA-109636
(
R-HSA-73779
)
R-HSA-109636
Reaction Name: Recognition and Binding of Core Promoter Elements by TFIID
See in Reactome
R-HSA-109637
(
R-HSA-73779
)
R-HSA-109637
Reaction Name: Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex
See in Reactome
R-HSA-109638
(
R-HSA-73779
)
R-HSA-109638
Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
See in Reactome
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-6805399
(
R-HSA-6804756
)
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-75095
(
R-HSA-73779
)
R-HSA-75095
Reaction Name: Binding of TFIIE to the growing preinitiation complex
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
|
MONDO:0010500 |
TAF1 |
P21675 |
2.7.11.1
2.3.1.48
|
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-212436
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73857
R-HSA-5633007
R-HSA-74160
|
Gene expression (Transcription)
|
R-HSA-109636
(
R-HSA-73779
)
R-HSA-109636
Reaction Name: Recognition and Binding of Core Promoter Elements by TFIID
See in Reactome
R-HSA-109637
(
R-HSA-73779
)
R-HSA-109637
Reaction Name: Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex
See in Reactome
R-HSA-109638
(
R-HSA-73779
)
R-HSA-109638
Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
See in Reactome
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-6805399
(
R-HSA-6804756
)
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-75095
(
R-HSA-73779
)
R-HSA-75095
Reaction Name: Binding of TFIIE to the growing preinitiation complex
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
|
MONDO:0014595 |
SIK1 |
P57059 |
2.7.11.1
|
R-HSA-400253
|
|
Circadian Clock
|
R-HSA-549533
(
R-HSA-400253
)
|
MONDO:0033008 |
TP53RK |
Q96S44 |
3.6.-.-
2.7.11.1
|
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-6782315
R-HSA-6782315
Reactome Name: tRNA modification in the nucleus and cytosol
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-8953854
R-HSA-72306
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
|
R-HSA-6784494
(
R-HSA-6782315
)
R-HSA-6784494
Reaction Name: EKC complex threonylcarbamoylates A37 of tRNAs
See in Reactome
R-HSA-6805479
(
R-HSA-6804756
)
|
MONDO:0018907 |
MONDO:0018907
Disease Name: craniopharyngioma
Orphanet id: Orphanet:54595
All associated enzymes in DAR:
BRAF
. The disease is also associated to other non-enzyme proteins (not in DAR).
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0011613 |
PINK1 |
Q9BXM7 |
2.7.11.1
|
R-HSA-5205685
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
|
R-HSA-1632852
R-HSA-9612973
R-HSA-9614085
R-HSA-74160
R-HSA-9663891
R-HSA-212436
R-HSA-5205647
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
|
R-HSA-5205652
(
R-HSA-1632852;
R-HSA-5205685
)
R-HSA-5205652
Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane.
See in Reactome
R-HSA-5205661
(
R-HSA-1632852;
R-HSA-5205685
)
R-HSA-5205661
Reaction Name: Pink1 is recruited from the cytoplasm to the mitochondria
See in Reactome
R-HSA-5205672
(
R-HSA-1632852;
R-HSA-5205685
)
R-HSA-5205672
Reaction Name: Uncleaved Pink1 accumulates in damaged mitochondria
See in Reactome
R-HSA-5205681
(
R-HSA-1632852;
R-HSA-5205685
)
R-HSA-5205681
Reaction Name: Pink1 is cleaved on healthy mitochondria
See in Reactome
R-HSA-5205682
(
R-HSA-1632852;
R-HSA-5205685
)
R-HSA-5205682
Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates
See in Reactome
R-HSA-9621289
(
R-HSA-9614657
)
R-HSA-9621289
Reaction Name: PINK1 gene expression is stimulated by FOXO1,FOXO3
See in Reactome
|
MONDO:0017812 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0010417 |
CASK |
O14936 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
R-HSA-212676
R-HSA-212676
Reactome Name: Dopamine Neurotransmitter Release Cycle
See in Reactome
R-HSA-6794361
R-HSA-3000170
R-HSA-373753
R-HSA-9609736
R-HSA-9609736
Reactome Name: Assembly and cell surface presentation of NMDA receptors
See in Reactome
|
R-HSA-9659379
R-HSA-1500931
R-HSA-9709957
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-3000171
R-HSA-3000171
Reactome Name: Non-integrin membrane-ECM interactions
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-112310
|
Cell-Cell communication
Sensory Perception
Extracellular matrix organization
Neuronal System
|
R-HSA-2750181
(
R-HSA-3000170
)
R-HSA-373722
(
R-HSA-373753
)
R-HSA-380574
(
R-HSA-212676
)
R-HSA-380574
Reaction Name: Dopamine synaptic vesicle docking and priming
See in Reactome
R-HSA-5336443
(
R-HSA-212676
)
R-HSA-6794352
(
R-HSA-6794361
)
R-HSA-6794352
Reaction Name: NRXNs binds CASK tripartite complex
See in Reactome
R-HSA-6797553
(
R-HSA-6794361
)
R-HSA-6797568
(
R-HSA-6794361
)
R-HSA-9610408
(
R-HSA-9609736
)
R-HSA-9610408
Reaction Name: GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17
See in Reactome
R-HSA-9610627
(
R-HSA-9609736
)
R-HSA-9610627
Reaction Name: KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
See in Reactome
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0030036 |
EIF2AK1 |
Q9BQI3 |
2.7.11.1
|
R-HSA-9648895
R-HSA-9648895
Reactome Name: Response of EIF2AK1 (HRI) to heme deficiency
See in Reactome
|
R-HSA-8953897
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-9648880
(
R-HSA-9648895
)
R-HSA-9648880
Reaction Name: Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer
See in Reactome
R-HSA-9648883
(
R-HSA-9648895
)
R-HSA-9648883
Reaction Name: p-T-EIF2AK1:ferriheme dimer autophosphorylates
See in Reactome
R-HSA-9648888
(
R-HSA-9648895
)
R-HSA-9648888
Reaction Name: p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)
See in Reactome
|
MONDO:0015278 |
STK11 |
Q15831 |
2.7.11.1
|
R-HSA-163680
R-HSA-163680
Reactome Name: AMPK inhibits chREBP transcriptional activation activity
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-9614085
R-HSA-74160
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-165159
R-HSA-212436
R-HSA-1430728
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism
Signal Transduction
|
R-HSA-164151
(
R-HSA-163680
)
R-HSA-164151
Reaction Name: LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
See in Reactome
R-HSA-200421
(
R-HSA-380972
)
R-HSA-200421
Reaction Name: Activation of cytosolic AMPK by phosphorylation
See in Reactome
R-HSA-3222006
(
R-HSA-6804756
)
R-HSA-3222006
Reaction Name: STK11 (LKB1) phosphorylates NUAK1
See in Reactome
R-HSA-3222020
(
R-HSA-6804756
)
R-HSA-380942
(
R-HSA-380972
)
R-HSA-380942
Reaction Name: LKB1 forms a trimeric complex with STRAD and MO25
See in Reactome
R-HSA-6805035
(
R-HSA-6804756
)
R-HSA-9625378
(
R-HSA-9614657
)
R-HSA-9625378
Reaction Name: STK11 gene transcription is stimulated by FOXO3,FOXO4
See in Reactome
|
MONDO:0008318 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013412 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0019438 |
LATS1 |
O95835 |
2.7.11.1
|
R-HSA-2028269
|
R-HSA-162582
|
Signal Transduction
|
R-HSA-2028555
(
R-HSA-2028269
)
R-HSA-2028555
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
See in Reactome
R-HSA-2028589
(
R-HSA-2028269
)
R-HSA-2028589
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
See in Reactome
R-HSA-2028598
(
R-HSA-2028269
)
R-HSA-2028598
Reaction Name: Phosphorylation of YAP by LATS1
See in Reactome
R-HSA-2028626
(
R-HSA-2028269
)
R-HSA-2028626
Reaction Name: Phosphorylated MOB1A proteins associate with LATS proteins
See in Reactome
R-HSA-2028673
(
R-HSA-2028269
)
R-HSA-2028673
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
See in Reactome
R-HSA-2028679
(
R-HSA-2028269
)
R-HSA-2028679
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
See in Reactome
R-HSA-2038398
(
R-HSA-2028269
)
R-HSA-2038398
Reaction Name: KIBRA (WWC1) binds LATS proteins
See in Reactome
R-HSA-2059926
(
R-HSA-2028269
)
R-HSA-2059926
Reaction Name: NPHP4 protein binds LATS proteins
See in Reactome
R-HSA-2060328
(
R-HSA-2028269
)
R-HSA-2060328
Reaction Name: Phosphorylation of WWTR1 (TAZ) by LATS1
See in Reactome
|
MONDO:0012714 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0017101 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0013999 |
ALPK1 |
Q96QP1 |
2.7.11.1
|
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-9645394
(
R-HSA-9645460
)
R-HSA-9645394
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645414
(
R-HSA-9645460
)
R-HSA-9645414
Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
See in Reactome
R-HSA-9645428
(
R-HSA-9645460
)
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-9645481
(
R-HSA-9645460
)
R-HSA-9645501
(
R-HSA-9645460
)
R-HSA-9645501
Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex
See in Reactome
R-HSA-9645520
(
R-HSA-9645460
)
R-HSA-9645520
Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
See in Reactome
R-HSA-9645524
(
R-HSA-9645460
)
R-HSA-9645535
(
R-HSA-9645460
)
|
MONDO:0008304 |
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0018935 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0016575 |
STK36 |
Q9NRP7 |
2.7.11.1
|
|
|
|
|
MONDO:0010318 |
CASK |
O14936 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
R-HSA-212676
R-HSA-212676
Reactome Name: Dopamine Neurotransmitter Release Cycle
See in Reactome
R-HSA-6794361
R-HSA-3000170
R-HSA-373753
R-HSA-9609736
R-HSA-9609736
Reactome Name: Assembly and cell surface presentation of NMDA receptors
See in Reactome
|
R-HSA-9659379
R-HSA-1500931
R-HSA-9709957
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-3000171
R-HSA-3000171
Reactome Name: Non-integrin membrane-ECM interactions
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-112310
|
Cell-Cell communication
Sensory Perception
Extracellular matrix organization
Neuronal System
|
R-HSA-2750181
(
R-HSA-3000170
)
R-HSA-373722
(
R-HSA-373753
)
R-HSA-380574
(
R-HSA-212676
)
R-HSA-380574
Reaction Name: Dopamine synaptic vesicle docking and priming
See in Reactome
R-HSA-5336443
(
R-HSA-212676
)
R-HSA-6794352
(
R-HSA-6794361
)
R-HSA-6794352
Reaction Name: NRXNs binds CASK tripartite complex
See in Reactome
R-HSA-6797553
(
R-HSA-6794361
)
R-HSA-6797568
(
R-HSA-6794361
)
R-HSA-9610408
(
R-HSA-9609736
)
R-HSA-9610408
Reaction Name: GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17
See in Reactome
R-HSA-9610627
(
R-HSA-9609736
)
R-HSA-9610627
Reaction Name: KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
See in Reactome
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0009821 |
FAM20C |
Q8IXL6 |
2.7.11.1
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
|
MONDO:0016419 |
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0011996 |
BCR |
P11274 |
2.7.11.1
|
R-HSA-9013106
R-HSA-8980692
R-HSA-9013026
R-HSA-9013423
R-HSA-9013404
R-HSA-9013149
R-HSA-9013148
|
R-HSA-162582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-9013022
(
R-HSA-9013026
)
R-HSA-9013022
Reaction Name: RHOB GAPs stimulate RHOB GTPase activity
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013111
(
R-HSA-9013106
)
R-HSA-9013111
Reaction Name: RHOC GAPs stimulate RHOC GTPase activity
See in Reactome
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014295
(
R-HSA-9013404
)
R-HSA-9014295
Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity
See in Reactome
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9018806
(
R-HSA-9013423
)
R-HSA-9018806
Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity
See in Reactome
|
MONDO:0009461 |
AURKC |
Q9UQB9 |
2.7.11.1
|
|
|
|
|
MONDO:0009192 |
EIF2AK3 |
Q9NZJ5 |
2.7.11.1
|
R-HSA-381042
|
R-HSA-381119
R-HSA-381119
Reactome Name: Unfolded Protein Response (UPR)
See in Reactome
R-HSA-8953897
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-381086
(
R-HSA-381042
)
R-HSA-381086
Reaction Name: Dissociation of PERK:BiP Heterodimer
See in Reactome
R-HSA-381087
(
R-HSA-381042
)
R-HSA-381111
(
R-HSA-381042
)
R-HSA-381111
Reaction Name: EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
See in Reactome
|
MONDO:0016419 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013660 |
NEK9 |
Q8TD19 |
2.7.11.1
|
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-2980767
R-HSA-2980767
Reactome Name: Activation of NIMA Kinases NEK9, NEK6, NEK7
See in Reactome
R-HSA-3301854
R-HSA-3301854
Reactome Name: Nuclear Pore Complex (NPC) Disassembly
See in Reactome
|
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-2980766
R-HSA-68875
|
Cell Cycle
|
R-HSA-2980720
(
R-HSA-2980767
)
R-HSA-2980720
Reaction Name: NEK9 binds NEK6/NEK7 in the cytosol
See in Reactome
R-HSA-2984220
(
R-HSA-2980767
)
R-HSA-2984226
(
R-HSA-2980767
)
R-HSA-2984258
(
R-HSA-2980767
)
R-HSA-2990880
(
R-HSA-3301854
)
R-HSA-2990880
Reaction Name: NEK6/NEK7 phosphorylates NUP98
See in Reactome
R-HSA-9648017
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648089
Reaction Name: NEK6 and NEK7 phosphorylate EML4
See in Reactome
|
MONDO:0012690 |
RAF1 |
P04049 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5621575
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-2672351
R-HSA-392517
R-HSA-5673000
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-168256
R-HSA-983712
R-HSA-168249
R-HSA-382551
R-HSA-1280218
R-HSA-5673001
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
|
Immune System
Transport of small molecules
Hemostasis
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-392835
(
R-HSA-392517
)
R-HSA-392835
Reaction Name: Rap1 sequesters Raf1 to inhibit ERK cascade
See in Reactome
R-HSA-443439
(
R-HSA-430116
)
R-HSA-443831
(
R-HSA-430116
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005611 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0015356 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0017403 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0014267 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-166058;
R-HSA-168928;
R-HSA-1810476;
R-HSA-1834949;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476;
R-HSA-1834949
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-209087
(
R-HSA-9020702
)
R-HSA-209087
Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-166058;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5684267
(
R-HSA-166058;
R-HSA-5684264;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-166058;
R-HSA-5684264;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0013778 |
WNK1 |
Q9H4A3 |
2.7.11.1
|
R-HSA-2672351
|
R-HSA-983712
R-HSA-382551
|
Transport of small molecules
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
|
MONDO:0014641 |
TBK1 |
Q9UHD2 |
2.7.11.1
|
R-HSA-3270619
R-HSA-3270619
Reactome Name: IRF3-mediated induction of type I IFN
See in Reactome
R-HSA-933541
R-HSA-3134975
R-HSA-3134975
Reactome Name: Regulation of innate immune responses to cytosolic DNA
See in Reactome
R-HSA-9013973
R-HSA-9013973
Reactome Name: TICAM1-dependent activation of IRF3/IRF7
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-1606341
R-HSA-1606341
Reactome Name: IRF3 mediated activation of type 1 IFN
See in Reactome
R-HSA-3249367
R-HSA-3249367
Reactome Name: STAT6-mediated induction of chemokines
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-9008059
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168898
R-HSA-449147
R-HSA-168256
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168249
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-1834941
R-HSA-1834941
Reactome Name: STING mediated induction of host immune responses
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-446652
|
Immune System
|
R-HSA-1606324
(
R-HSA-1606341
)
R-HSA-1606324
Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
See in Reactome
R-HSA-1606327
(
R-HSA-1606341
)
R-HSA-1606327
Reaction Name: Phosphorylation and release of IRF3
See in Reactome
R-HSA-1606345
(
R-HSA-1606341
)
R-HSA-1606345
Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1
See in Reactome
R-HSA-166245
(
R-HSA-936964
)
R-HSA-166245
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-1834939
(
R-HSA-3270619
)
R-HSA-2396002
(
R-HSA-3270619
)
R-HSA-2396002
Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex
See in Reactome
R-HSA-2396007
(
R-HSA-3270619
)
R-HSA-2396007
Reaction Name: IRF3 is phosphorylated by TBK1
See in Reactome
R-HSA-3249371
(
R-HSA-3249367
)
R-HSA-3249371
Reaction Name: TBK1 phosphorylates STAT6 at Ser407
See in Reactome
R-HSA-3249378
(
R-HSA-3249367
)
R-HSA-3249386
(
R-HSA-3134975
)
R-HSA-3249386
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-3249390
(
R-HSA-3249367
)
R-HSA-3249390
Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex
See in Reactome
R-HSA-3249392
(
R-HSA-3134975
)
R-HSA-3249392
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
See in Reactome
R-HSA-8948703
(
R-HSA-3134975
)
R-HSA-8948703
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-8948709
(
R-HSA-3134975
)
R-HSA-8948709
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
See in Reactome
R-HSA-9008684
(
R-HSA-9008059
)
R-HSA-9013978
(
R-HSA-9013973
)
R-HSA-9013978
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
See in Reactome
R-HSA-9013979
(
R-HSA-9013973
)
R-HSA-9013979
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
See in Reactome
R-HSA-9013986
(
R-HSA-9013973
)
R-HSA-9013986
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
See in Reactome
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-936941
(
R-HSA-936964
)
R-HSA-936941
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
See in Reactome
R-HSA-937337
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
R-HSA-9679819
(
R-HSA-1606341
)
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9709831
(
R-HSA-168928
)
R-HSA-9709852
(
R-HSA-168928
)
R-HSA-9709852
Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3
See in Reactome
|
MONDO:0005097 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005061 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0011464 |
TTBK2 |
Q6IQ55 |
2.7.11.1
|
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
|
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-5617833
|
Organelle biogenesis and maintenance
|
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
|
MONDO:0014716 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0010108 |
STK11 |
Q15831 |
2.7.11.1
|
R-HSA-163680
R-HSA-163680
Reactome Name: AMPK inhibits chREBP transcriptional activation activity
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-9614085
R-HSA-74160
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-165159
R-HSA-212436
R-HSA-1430728
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism
Signal Transduction
|
R-HSA-164151
(
R-HSA-163680
)
R-HSA-164151
Reaction Name: LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
See in Reactome
R-HSA-200421
(
R-HSA-380972
)
R-HSA-200421
Reaction Name: Activation of cytosolic AMPK by phosphorylation
See in Reactome
R-HSA-3222006
(
R-HSA-6804756
)
R-HSA-3222006
Reaction Name: STK11 (LKB1) phosphorylates NUAK1
See in Reactome
R-HSA-3222020
(
R-HSA-6804756
)
R-HSA-380942
(
R-HSA-380972
)
R-HSA-380942
Reaction Name: LKB1 forms a trimeric complex with STRAD and MO25
See in Reactome
R-HSA-6805035
(
R-HSA-6804756
)
R-HSA-9625378
(
R-HSA-9614657
)
R-HSA-9625378
Reaction Name: STK11 gene transcription is stimulated by FOXO3,FOXO4
See in Reactome
|
MONDO:0016419 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0018876 |
MONDO:0018876
Disease Name: mantle cell lymphoma
Orphanet id: Orphanet:52416
All associated enzymes in DAR:
ATM
. The disease is also associated to other non-enzyme proteins (not in DAR).
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0015447 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0014920 |
MAPKAPK3 |
Q16644 |
2.7.11.1
|
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-4420097
R-HSA-171007
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-168898
R-HSA-166166
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-167044
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-187688
(
R-HSA-171007;
R-HSA-4420097
)
R-HSA-187688
Reaction Name: p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
See in Reactome
R-HSA-3229102
(
R-HSA-2559580
)
R-HSA-3229102
Reaction Name: p-MAPKAPK3 phosphorylates BMI1
See in Reactome
R-HSA-3229138
(
R-HSA-2559580
)
R-HSA-3229138
Reaction Name: MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription
See in Reactome
R-HSA-450222
(
R-HSA-166058;
R-HSA-2559580;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450222
Reaction Name: Active p38 MAPK phosphorylates MAPKAPK2 or 3
See in Reactome
R-HSA-450257
(
R-HSA-166058;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450257
Reaction Name: Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
See in Reactome
R-HSA-450333
(
R-HSA-166058;
R-HSA-2559580;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450333
Reaction Name: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
See in Reactome
R-HSA-5218916
(
R-HSA-4420097
)
R-HSA-5218916
Reaction Name: p-MAPK2/3 phosphorylates HSP27
See in Reactome
|
MONDO:0021040 |
NEK8 |
Q86SG6 |
2.7.11.1
|
|
|
|
|
MONDO:0013038 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014256 |
NEK2 |
P51955 |
2.7.11.1
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-68877
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-453274
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-69278
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-5617833
R-HSA-380287
R-HSA-69275
|
Organelle biogenesis and maintenance
Cell Cycle
|
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320;
R-HSA-68877
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320;
R-HSA-68877
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0016216 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008093 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0007376 |
PIKFYVE |
Q9Y2I7 |
2.7.1.150
2.7.11.1
|
R-HSA-1660514
R-HSA-1660514
Reactome Name: Synthesis of PIPs at the Golgi membrane
See in Reactome
R-HSA-1660516
R-HSA-1660516
Reactome Name: Synthesis of PIPs at the early endosome membrane
See in Reactome
R-HSA-1660517
R-HSA-1660517
Reactome Name: Synthesis of PIPs at the late endosome membrane
See in Reactome
|
R-HSA-556833
R-HSA-1430728
R-HSA-1483257
R-HSA-1483255
|
Metabolism
|
R-HSA-1675866
(
R-HSA-1660517
)
R-HSA-1675866
Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675910
(
R-HSA-1660517
)
R-HSA-1675910
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
See in Reactome
R-HSA-1675921
(
R-HSA-1660514
)
R-HSA-1675921
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
See in Reactome
R-HSA-1676005
(
R-HSA-1660514
)
R-HSA-1676005
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
See in Reactome
R-HSA-1676020
(
R-HSA-1660517
)
R-HSA-1676020
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
See in Reactome
R-HSA-1676168
(
R-HSA-1660516
)
R-HSA-1676168
Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
See in Reactome
R-HSA-1676174
(
R-HSA-1660516
)
R-HSA-1676174
Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
See in Reactome
|
MONDO:0011400 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
OMIM:145400 |
RPS6KA3 |
P51812 |
2.7.11.1
|
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-198753
R-HSA-437239
R-HSA-199920
R-HSA-444257
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-2559583
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-2262752
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8953897
R-HSA-1266738
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-166520
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-9675108
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-373760
R-HSA-388396
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-372790
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-416476
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Cellular responses to stimuli
Developmental Biology
Neuronal System
Signal Transduction
|
R-HSA-198746
(
R-HSA-166058;
R-HSA-198753;
R-HSA-2559582;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
(
R-HSA-166058;
R-HSA-199920;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
Reaction Name: RSK1/2/3 phosphorylates CREB at Serine 133
See in Reactome
R-HSA-374696
(
R-HSA-437239
)
R-HSA-374696
Reaction Name: Phosphorylation of L1 by p90rsk
See in Reactome
R-HSA-3857328
(
R-HSA-2559582
)
R-HSA-3857328
Reaction Name: RPS6KA1/2/3 phosphorylates CEBPB on S321
See in Reactome
R-HSA-442724
(
R-HSA-442742
)
R-HSA-442724
Reaction Name: Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
See in Reactome
R-HSA-442739
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
Reaction Name: p-S363,S380,T573 RS6K translocates to the nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9620004
(
R-HSA-442742;
R-HSA-444257
)
|
MONDO:0012980 |
CILK1 |
Q9UPZ9 |
2.7.11.1
|
|
|
|
|
MONDO:0014396 |
RAF1 |
P04049 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5621575
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-2672351
R-HSA-392517
R-HSA-5673000
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-168256
R-HSA-983712
R-HSA-168249
R-HSA-382551
R-HSA-1280218
R-HSA-5673001
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
|
Immune System
Transport of small molecules
Hemostasis
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-392835
(
R-HSA-392517
)
R-HSA-392835
Reaction Name: Rap1 sequesters Raf1 to inhibit ERK cascade
See in Reactome
R-HSA-443439
(
R-HSA-430116
)
R-HSA-443831
(
R-HSA-430116
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0032914 |
NEK10 |
Q6ZWH5 |
2.7.11.1
|
|
|
|
|
MONDO:0005012 |
ARAF |
P10398 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5673000
|
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-5673001
|
Signal Transduction
|
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005335 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005138 |
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0011240 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0021230 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017401 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0021040 |
STK33 |
Q9BYT3 |
2.7.11.1
|
|
|
|
|
MONDO:0019438 |
SGK1 |
O00141 |
2.7.11.1
|
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-9031628
R-HSA-2672351
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-166520
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-983712
R-HSA-382551
R-HSA-212436
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-187037
R-HSA-73857
|
Gene expression (Transcription)
Transport of small molecules
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-6795460
(
R-HSA-6804757
)
R-HSA-6795473
(
R-HSA-6804757
)
R-HSA-9022764
(
R-HSA-8986944
)
R-HSA-9022764
Reaction Name: SGK1 gene expression is inhibited by MECP2
See in Reactome
R-HSA-9612501
(
R-HSA-9031628
)
R-HSA-9612509
(
R-HSA-9031628
)
|
MONDO:0008959 |
RIPK4 |
P57078 |
2.7.11.1
|
|
|
|
|
MONDO:0013108 |
BCR |
P11274 |
2.7.11.1
|
R-HSA-9013106
R-HSA-8980692
R-HSA-9013026
R-HSA-9013423
R-HSA-9013404
R-HSA-9013149
R-HSA-9013148
|
R-HSA-162582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-194315
R-HSA-9012999
|
Signal Transduction
|
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-9013022
(
R-HSA-9013026
)
R-HSA-9013022
Reaction Name: RHOB GAPs stimulate RHOB GTPase activity
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9013111
(
R-HSA-9013106
)
R-HSA-9013111
Reaction Name: RHOC GAPs stimulate RHOC GTPase activity
See in Reactome
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014295
(
R-HSA-9013404
)
R-HSA-9014295
Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity
See in Reactome
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9018806
(
R-HSA-9013423
)
R-HSA-9018806
Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity
See in Reactome
|
MONDO:0014080 |
LRRK1 |
Q38SD2 |
2.7.11.1
|
|
|
|
|
MONDO:0014088 |
CSNK1D |
P48730 |
2.7.11.26
2.7.11.1
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-400253
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-6791226
R-HSA-6791226
Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-380287
R-HSA-68886
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-8953854
R-HSA-8868773
R-HSA-8868773
Reactome Name: rRNA processing in the nucleus and cytosol
See in Reactome
R-HSA-453274
R-HSA-392499
R-HSA-68877
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-69278
R-HSA-72312
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5617833
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-69275
R-HSA-5653656
|
Circadian Clock
Organelle biogenesis and maintenance
Metabolism of RNA
Metabolism of proteins
Cell Cycle
Vesicle-mediated transport
|
R-HSA-1856948
(
R-HSA-400253
)
R-HSA-1856948
Reaction Name: Formation of CRY:PER:Kinase complex
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320;
R-HSA-68877
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320;
R-HSA-68877
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-400256
(
R-HSA-400253
)
R-HSA-400256
Reaction Name: CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer
See in Reactome
R-HSA-400382
(
R-HSA-400253
)
R-HSA-400382
Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins
See in Reactome
R-HSA-549385
(
R-HSA-400253
)
R-HSA-549385
Reaction Name: CRY:PER:Kinase complex translocates to the nucleus
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5694441
(
R-HSA-204005
)
R-HSA-6791223
(
R-HSA-6791226
)
R-HSA-6791223
Reaction Name: 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0016692 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0032908 |
MONDO:0032908
Disease Name: CEBALID syndrome
OMIM id: OMIM:618774
All associated enzymes in DAR:
MTOR
. The disease is also associated to other non-enzyme proteins (not in DAR).
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0009693 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0017102 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0008328 |
TBK1 |
Q9UHD2 |
2.7.11.1
|
R-HSA-3270619
R-HSA-3270619
Reactome Name: IRF3-mediated induction of type I IFN
See in Reactome
R-HSA-933541
R-HSA-3134975
R-HSA-3134975
Reactome Name: Regulation of innate immune responses to cytosolic DNA
See in Reactome
R-HSA-9013973
R-HSA-9013973
Reactome Name: TICAM1-dependent activation of IRF3/IRF7
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-1606341
R-HSA-1606341
Reactome Name: IRF3 mediated activation of type 1 IFN
See in Reactome
R-HSA-3249367
R-HSA-3249367
Reactome Name: STAT6-mediated induction of chemokines
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-9008059
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168898
R-HSA-449147
R-HSA-168256
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168249
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-1834941
R-HSA-1834941
Reactome Name: STING mediated induction of host immune responses
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-446652
|
Immune System
|
R-HSA-1606324
(
R-HSA-1606341
)
R-HSA-1606324
Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
See in Reactome
R-HSA-1606327
(
R-HSA-1606341
)
R-HSA-1606327
Reaction Name: Phosphorylation and release of IRF3
See in Reactome
R-HSA-1606345
(
R-HSA-1606341
)
R-HSA-1606345
Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1
See in Reactome
R-HSA-166245
(
R-HSA-936964
)
R-HSA-166245
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-1834939
(
R-HSA-3270619
)
R-HSA-2396002
(
R-HSA-3270619
)
R-HSA-2396002
Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex
See in Reactome
R-HSA-2396007
(
R-HSA-3270619
)
R-HSA-2396007
Reaction Name: IRF3 is phosphorylated by TBK1
See in Reactome
R-HSA-3249371
(
R-HSA-3249367
)
R-HSA-3249371
Reaction Name: TBK1 phosphorylates STAT6 at Ser407
See in Reactome
R-HSA-3249378
(
R-HSA-3249367
)
R-HSA-3249386
(
R-HSA-3134975
)
R-HSA-3249386
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-3249390
(
R-HSA-3249367
)
R-HSA-3249390
Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex
See in Reactome
R-HSA-3249392
(
R-HSA-3134975
)
R-HSA-3249392
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
See in Reactome
R-HSA-8948703
(
R-HSA-3134975
)
R-HSA-8948703
Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
See in Reactome
R-HSA-8948709
(
R-HSA-3134975
)
R-HSA-8948709
Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
See in Reactome
R-HSA-9008684
(
R-HSA-9008059
)
R-HSA-9013978
(
R-HSA-9013973
)
R-HSA-9013978
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
See in Reactome
R-HSA-9013979
(
R-HSA-9013973
)
R-HSA-9013979
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
See in Reactome
R-HSA-9013986
(
R-HSA-9013973
)
R-HSA-9013986
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
See in Reactome
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-936941
(
R-HSA-936964
)
R-HSA-936941
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
See in Reactome
R-HSA-937337
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
R-HSA-9679819
(
R-HSA-1606341
)
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9709831
(
R-HSA-168928
)
R-HSA-9709852
(
R-HSA-168928
)
R-HSA-9709852
Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3
See in Reactome
|
MONDO:0014876 |
TNIK |
Q9UKE5 |
2.7.11.1
|
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
|
R-HSA-8953897
R-HSA-2262752
R-HSA-2559583
|
Cellular responses to stimuli
|
R-HSA-3225851
(
R-HSA-2559580
)
R-HSA-3225851
Reaction Name: ROS oxidize thioredoxin and activate MAP3K5
See in Reactome
R-HSA-3225867
(
R-HSA-2559580
)
R-HSA-3225867
Reaction Name: Expression of MINK1/TNIK is positively regulated by ROS
See in Reactome
|
MONDO:0019438 |
AURKA |
O14965 |
2.7.11.1
|
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8854521
R-HSA-8854521
Reactome Name: Interaction between PHLDA1 and AURKA
See in Reactome
R-HSA-8854518
R-HSA-6804114
R-HSA-6804114
Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
See in Reactome
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69278
R-HSA-6791312
R-HSA-6791312
Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes
See in Reactome
R-HSA-2990846
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-69275
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
|
R-HSA-174088
(
R-HSA-174178
)
R-HSA-174088
Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174195
(
R-HSA-174178
)
R-HSA-174195
Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-4655404
(
R-HSA-4615885
)
R-HSA-4655404
Reaction Name: SUMOylation of AURKA with SUMO1
See in Reactome
R-HSA-6791235
(
R-HSA-6804114
)
R-HSA-6805103
(
R-HSA-6804756
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8853429
(
R-HSA-8854521
)
R-HSA-8853444
(
R-HSA-8854521
)
R-HSA-8853496
(
R-HSA-8854050
)
R-HSA-8854041
(
R-HSA-8854050
)
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
|
MONDO:0018750 |
CASK |
O14936 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
R-HSA-212676
R-HSA-212676
Reactome Name: Dopamine Neurotransmitter Release Cycle
See in Reactome
R-HSA-6794361
R-HSA-3000170
R-HSA-373753
R-HSA-9609736
R-HSA-9609736
Reactome Name: Assembly and cell surface presentation of NMDA receptors
See in Reactome
|
R-HSA-9659379
R-HSA-1500931
R-HSA-9709957
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-3000171
R-HSA-3000171
Reactome Name: Non-integrin membrane-ECM interactions
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-112310
|
Cell-Cell communication
Sensory Perception
Extracellular matrix organization
Neuronal System
|
R-HSA-2750181
(
R-HSA-3000170
)
R-HSA-373722
(
R-HSA-373753
)
R-HSA-380574
(
R-HSA-212676
)
R-HSA-380574
Reaction Name: Dopamine synaptic vesicle docking and priming
See in Reactome
R-HSA-5336443
(
R-HSA-212676
)
R-HSA-6794352
(
R-HSA-6794361
)
R-HSA-6794352
Reaction Name: NRXNs binds CASK tripartite complex
See in Reactome
R-HSA-6797553
(
R-HSA-6794361
)
R-HSA-6797568
(
R-HSA-6794361
)
R-HSA-9610408
(
R-HSA-9609736
)
R-HSA-9610408
Reaction Name: GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17
See in Reactome
R-HSA-9610627
(
R-HSA-9609736
)
R-HSA-9610627
Reaction Name: KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
See in Reactome
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0019192 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0015802 |
BRSK2 |
Q8IWQ3 |
2.7.11.26
2.7.11.1
|
|
|
|
|
MONDO:0018759 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0009693 |
LATS1 |
O95835 |
2.7.11.1
|
R-HSA-2028269
|
R-HSA-162582
|
Signal Transduction
|
R-HSA-2028555
(
R-HSA-2028269
)
R-HSA-2028555
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
See in Reactome
R-HSA-2028589
(
R-HSA-2028269
)
R-HSA-2028589
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
See in Reactome
R-HSA-2028598
(
R-HSA-2028269
)
R-HSA-2028598
Reaction Name: Phosphorylation of YAP by LATS1
See in Reactome
R-HSA-2028626
(
R-HSA-2028269
)
R-HSA-2028626
Reaction Name: Phosphorylated MOB1A proteins associate with LATS proteins
See in Reactome
R-HSA-2028673
(
R-HSA-2028269
)
R-HSA-2028673
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
See in Reactome
R-HSA-2028679
(
R-HSA-2028269
)
R-HSA-2028679
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
See in Reactome
R-HSA-2038398
(
R-HSA-2028269
)
R-HSA-2038398
Reaction Name: KIBRA (WWC1) binds LATS proteins
See in Reactome
R-HSA-2059926
(
R-HSA-2028269
)
R-HSA-2059926
Reaction Name: NPHP4 protein binds LATS proteins
See in Reactome
R-HSA-2060328
(
R-HSA-2028269
)
R-HSA-2060328
Reaction Name: Phosphorylation of WWTR1 (TAZ) by LATS1
See in Reactome
|
MONDO:0014048 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011888 |
IRAK4 |
Q9NWZ3 |
2.7.11.1
|
R-HSA-9020702
R-HSA-1257604
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975110
R-HSA-975110
Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
|
R-HSA-168898
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-449147
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168249
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-162582
R-HSA-446652
|
Immune System
Signal Transduction
|
R-HSA-166082
(
R-HSA-166058
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-446634
(
R-HSA-9020702
)
R-HSA-446634
Reaction Name: IRAK4 is activated by autophosphorylation
See in Reactome
R-HSA-446648
(
R-HSA-9020702
)
R-HSA-446648
Reaction Name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4
See in Reactome
R-HSA-446684
(
R-HSA-9020702
)
R-HSA-446684
Reaction Name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
See in Reactome
R-HSA-446692
(
R-HSA-9020702
)
R-HSA-446692
Reaction Name: IRAK1 binds to MYD88 within the IL1R complex
See in Reactome
R-HSA-446694
(
R-HSA-9020702
)
R-HSA-446701
(
R-HSA-9020702
)
R-HSA-446701
Reaction Name: IRAK4-activated IRAK1 autophosphorylates
See in Reactome
R-HSA-446862
(
R-HSA-9020702
)
R-HSA-446862
Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6
See in Reactome
R-HSA-446868
(
R-HSA-9020702
)
R-HSA-446868
Reaction Name: The Interleukin 1 receptor complex binds Tollip
See in Reactome
R-HSA-446894
(
R-HSA-9020702
)
R-HSA-446894
Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release
See in Reactome
R-HSA-450690
(
R-HSA-9020702
)
R-HSA-450690
Reaction Name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3
See in Reactome
R-HSA-450827
(
R-HSA-9020702
)
R-HSA-450827
Reaction Name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.
See in Reactome
R-HSA-8948063
(
R-HSA-9020702
)
R-HSA-8948063
Reaction Name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1
See in Reactome
R-HSA-937022
(
R-HSA-166058
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-975100
(
R-HSA-975138;
R-HSA-975155
)
R-HSA-975100
Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975106
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975106
Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975111
(
R-HSA-975155
)
R-HSA-975111
Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
See in Reactome
R-HSA-975115
(
R-HSA-975155
)
R-HSA-975115
Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.
See in Reactome
R-HSA-975118
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975118
Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975125
(
R-HSA-975155
)
R-HSA-975125
Reaction Name: Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
See in Reactome
R-HSA-975134
(
R-HSA-975155
)
R-HSA-975134
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
See in Reactome
R-HSA-975156
(
R-HSA-975155
)
R-HSA-975156
Reaction Name: IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
See in Reactome
R-HSA-975160
(
R-HSA-975155
)
R-HSA-975160
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
See in Reactome
R-HSA-975170
(
R-HSA-975155
)
R-HSA-975170
Reaction Name: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
See in Reactome
R-HSA-975180
(
R-HSA-975155
)
R-HSA-975180
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
See in Reactome
R-HSA-975188
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975188
Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975852
(
R-HSA-975871
)
R-HSA-975852
Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
See in Reactome
R-HSA-975853
(
R-HSA-975871
)
R-HSA-975853
Reaction Name: Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
See in Reactome
R-HSA-975857
(
R-HSA-975871
)
R-HSA-975857
Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2
See in Reactome
R-HSA-975861
(
R-HSA-975871
)
R-HSA-975861
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
See in Reactome
R-HSA-975865
(
R-HSA-975871
)
R-HSA-975865
Reaction Name: IRAK4 autophosphorylation within the complex activated TLR:MyD88
See in Reactome
R-HSA-975873
(
R-HSA-975871
)
R-HSA-975873
Reaction Name: IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
See in Reactome
R-HSA-975874
(
R-HSA-975871
)
R-HSA-975874
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
See in Reactome
R-HSA-975878
(
R-HSA-975871
)
R-HSA-975878
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
See in Reactome
R-HSA-975879
(
R-HSA-975871
)
R-HSA-975879
Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
See in Reactome
|
MONDO:0016996 |
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0011176 |
TRPM6 |
Q9BX84 |
2.7.11.1
|
R-HSA-3295583
|
R-HSA-983712
R-HSA-382551
R-HSA-2672351
|
Transport of small molecules
|
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
|
MONDO:0007104 |
TRPM7 |
Q96QT4 |
2.7.11.1
|
R-HSA-3295583
|
R-HSA-983712
R-HSA-382551
R-HSA-2672351
|
Transport of small molecules
|
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
|
MONDO:0015679 |
MASTL |
Q96GX5 |
2.7.11.1
|
R-HSA-2465910
R-HSA-2465910
Reactome Name: MASTL Facilitates Mitotic Progression
See in Reactome
|
R-HSA-1640170
R-HSA-68886
R-HSA-69278
R-HSA-68875
|
Cell Cycle
|
R-HSA-2168079
(
R-HSA-2465910
)
R-HSA-2168079
Reaction Name: MASTL (GWL) phosphorylates ARPP19
See in Reactome
R-HSA-2430533
(
R-HSA-2465910
)
R-HSA-2430535
(
R-HSA-2465910
)
|
MONDO:0013806 |
ATR |
Q13535 |
2.7.11.1
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-69473
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-6783310
R-HSA-176187
R-HSA-176187
Reactome Name: Activation of ATR in response to replication stress
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-5633007
R-HSA-69481
R-HSA-69620
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-2262752
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-1500620
R-HSA-5693538
R-HSA-1640170
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Cell Cycle
DNA Repair
Reproduction
|
R-HSA-176116
(
R-HSA-176187;
R-HSA-69473
)
R-HSA-176116
Reaction Name: Recruitment and activation of Chk1
See in Reactome
R-HSA-176250
(
R-HSA-176187
)
R-HSA-176250
Reaction Name: Binding of ATR-ATRIP to the RPA-ssDNA complex
See in Reactome
R-HSA-176298
(
R-HSA-176187
)
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693561
(
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
|
MONDO:0009901 |
RIPK4 |
P57078 |
2.7.11.1
|
|
|
|
|
MONDO:0030035 |
EIF2AK2 |
P19525 |
2.7.10.2
2.7.11.1
|
R-HSA-1169408
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
|
Immune System
|
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
|
MONDO:0008420 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005061 |
ARAF |
P10398 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5673000
|
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-5673001
|
Signal Transduction
|
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0009416 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005611 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0004948 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-1632852;
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0015705 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0032568 |
PAK1 |
Q13153 |
2.7.11.1
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-376172
R-HSA-428540
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-5627123
R-HSA-9013424
R-HSA-5625740
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-9013423
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-9013149
R-HSA-9013148
R-HSA-5627117
R-HSA-3928664
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-445144
R-HSA-9013420
R-HSA-9013409
R-HSA-9013406
R-HSA-9013407
R-HSA-9013404
R-HSA-445355
R-HSA-8964616
R-HSA-8964616
Reactome Name: G beta:gamma signalling through CDC42
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-397014
R-HSA-168256
R-HSA-194315
R-HSA-373760
R-HSA-1280218
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-202403
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-2682334
R-HSA-195258
R-HSA-372790
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-373755
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-373752
|
Muscle contraction
Immune System
Developmental Biology
Signal Transduction
|
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029460
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730887
(
R-HSA-2871796
)
R-HSA-2730887
Reaction Name: Autophosphorylation and activation of MEKK1
See in Reactome
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-389788
(
R-HSA-388841;
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-419232
(
R-HSA-5625740;
R-HSA-5627117;
R-HSA-5627123
)
R-HSA-419232
Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain
See in Reactome
R-HSA-428531
(
R-HSA-428540
)
R-HSA-430183
(
R-HSA-202433
)
R-HSA-442832
(
R-HSA-5627123
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-445797
(
R-HSA-445355;
R-HSA-5627123
)
R-HSA-445797
Reaction Name: MYLK (MLCK) Active Calmodulin Binding
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
Reaction Name: PAK1-3 phosphorylates VE-cadherin
See in Reactome
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5668947
(
R-HSA-5627123
)
R-HSA-5668947
Reaction Name: PAK1 phosphorylates myosin phosphatase
See in Reactome
R-HSA-5668984
(
R-HSA-5627123
)
R-HSA-5668984
Reaction Name: PAK1 or PAK2 phosphorylates MYLK
See in Reactome
R-HSA-5669158
(
R-HSA-5627123
)
R-HSA-5669240
(
R-HSA-5627123
)
R-HSA-5669250
(
R-HSA-5627123
)
R-HSA-5687086
(
R-HSA-5687128
)
R-HSA-5687086
Reaction Name: PAK1,2,3 phosphorylates MAPK6,4
See in Reactome
R-HSA-8964599
(
R-HSA-8964616
)
R-HSA-8964599
Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
See in Reactome
R-HSA-8964604
(
R-HSA-8964616
)
R-HSA-8964604
Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
See in Reactome
R-HSA-8964605
(
R-HSA-8964616
)
R-HSA-8964605
Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex
See in Reactome
R-HSA-8964614
(
R-HSA-8964616
)
R-HSA-8964614
Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
See in Reactome
R-HSA-8964619
(
R-HSA-8964616
)
R-HSA-8964634
(
R-HSA-8964616
)
R-HSA-8964634
Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
R-HSA-9018794
(
R-HSA-9013424
)
R-HSA-9018794
Reaction Name: RHOV binds effectors at the plasma membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
|
MONDO:0018177 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0017566 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016642 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0014500 |
TNNI3K |
Q59H18 |
2.7.11.1
|
|
|
|
|
MONDO:0032571 |
SIK3 |
Q9Y2K2 |
2.7.11.1
|
|
|
|
|
MONDO:0005148 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011362 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0011774 |
MYO3A |
Q8NEV4 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
|
R-HSA-9659379
R-HSA-9709957
|
Sensory Perception
|
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0033968 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0008170 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0009693 |
SGK1 |
O00141 |
2.7.11.1
|
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-9031628
R-HSA-2672351
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-166520
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-983712
R-HSA-382551
R-HSA-212436
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-187037
R-HSA-73857
|
Gene expression (Transcription)
Transport of small molecules
Signal Transduction
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-6795460
(
R-HSA-6804757
)
R-HSA-6795473
(
R-HSA-6804757
)
R-HSA-9022764
(
R-HSA-8986944
)
R-HSA-9022764
Reaction Name: SGK1 gene expression is inhibited by MECP2
See in Reactome
R-HSA-9612501
(
R-HSA-9031628
)
R-HSA-9612509
(
R-HSA-9031628
)
|
MONDO:0005233 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0009329 |
EIF2AK4 |
Q9P2K8 |
2.7.11.1
|
R-HSA-9633012
R-HSA-9633012
Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency
See in Reactome
|
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-8953897
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-9633005
(
R-HSA-9633012
)
R-HSA-9633008
(
R-HSA-9633012
)
R-HSA-9633008
Reaction Name: p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1
See in Reactome
R-HSA-9633742
(
R-HSA-9633012
)
R-HSA-9633742
Reaction Name: EIF2AK4 (GCN2) dimer autophosphorylates
See in Reactome
|
MONDO:0010447 |
RPS6KA3 |
P51812 |
2.7.11.1
|
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-198753
R-HSA-437239
R-HSA-199920
R-HSA-444257
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-2559583
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-2262752
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8953897
R-HSA-1266738
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-166520
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-9675108
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-373760
R-HSA-388396
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-372790
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-416476
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Cellular responses to stimuli
Developmental Biology
Neuronal System
Signal Transduction
|
R-HSA-198746
(
R-HSA-166058;
R-HSA-198753;
R-HSA-2559582;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
(
R-HSA-166058;
R-HSA-199920;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
Reaction Name: RSK1/2/3 phosphorylates CREB at Serine 133
See in Reactome
R-HSA-374696
(
R-HSA-437239
)
R-HSA-374696
Reaction Name: Phosphorylation of L1 by p90rsk
See in Reactome
R-HSA-3857328
(
R-HSA-2559582
)
R-HSA-3857328
Reaction Name: RPS6KA1/2/3 phosphorylates CEBPB on S321
See in Reactome
R-HSA-442724
(
R-HSA-442742
)
R-HSA-442724
Reaction Name: Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
See in Reactome
R-HSA-442739
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
Reaction Name: p-S363,S380,T573 RS6K translocates to the nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9620004
(
R-HSA-442742;
R-HSA-444257
)
|
MONDO:0007265 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0013127 |
NEK1 |
Q96PY6 |
2.7.11.1
|
|
|
|
|
MONDO:0010870 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0017094 |
FAM20C |
Q8IXL6 |
2.7.11.1
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
|
MONDO:0019392 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005012 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0009894 |
NEK1 |
Q96PY6 |
2.7.11.1
|
|
|
|
|
MONDO:0014047 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016419 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011764 |
LRRK2 |
Q5S007 |
3.6.5.-
2.7.11.1
|
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
|
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-8848021
R-HSA-162582
|
Signal Transduction
|
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
|
MONDO:0018314 |
TNK2 |
Q07912 |
2.7.10.2
2.7.11.1
|
|
|
|
|
MONDO:0018177 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0032939 |
TRIO |
O75962 |
2.7.11.1
|
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-9013423
R-HSA-416476
R-HSA-8980692
R-HSA-9013408
R-HSA-9013409
R-HSA-9013404
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-9013149
R-HSA-9013148
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-372790
R-HSA-9012999
R-HSA-388396
R-HSA-194315
R-HSA-9675108
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1266738
R-HSA-373752
|
Signal Transduction
Developmental Biology
|
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-400586
(
R-HSA-416476
)
R-HSA-400586
Reaction Name: G alpha (q) binds to Trio family RhoGEFs
See in Reactome
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9014433
(
R-HSA-9013408
)
R-HSA-9017491
(
R-HSA-9013409
)
R-HSA-9018804
(
R-HSA-9013423
)
|
MONDO:0020492 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013934 |
STK4 |
Q13043 |
2.7.11.1
|
R-HSA-2028269
|
R-HSA-162582
|
Signal Transduction
|
R-HSA-2028284
(
R-HSA-2028269
)
R-HSA-2028284
Reaction Name: Phosphorylation of STK4 (MST1) and SAV1 by STK4
See in Reactome
R-HSA-2028555
(
R-HSA-2028269
)
R-HSA-2028555
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
See in Reactome
R-HSA-2028629
(
R-HSA-2028269
)
R-HSA-2028629
Reaction Name: Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
See in Reactome
R-HSA-2028670
(
R-HSA-2028269
)
R-HSA-2028670
Reaction Name: Phosphorylation of MOB1A and B by p-STK4(MST1)/N
See in Reactome
R-HSA-2028679
(
R-HSA-2028269
)
R-HSA-2028679
Reaction Name: Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
See in Reactome
R-HSA-2028692
(
R-HSA-2028269
)
R-HSA-2028692
Reaction Name: Cleavage of p-STK4 (p-MST1) by caspase 3
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0010561 |
RPS6KA3 |
P51812 |
2.7.11.1
|
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-198753
R-HSA-437239
R-HSA-199920
R-HSA-444257
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-2559583
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-2262752
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8953897
R-HSA-1266738
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-166520
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-9675108
R-HSA-168898
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-373760
R-HSA-388396
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-187037
R-HSA-450294
R-HSA-372790
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-416476
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Cellular responses to stimuli
Developmental Biology
Neuronal System
Signal Transduction
|
R-HSA-198746
(
R-HSA-166058;
R-HSA-198753;
R-HSA-2559582;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
(
R-HSA-166058;
R-HSA-199920;
R-HSA-416476;
R-HSA-881907;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-199895
Reaction Name: RSK1/2/3 phosphorylates CREB at Serine 133
See in Reactome
R-HSA-374696
(
R-HSA-437239
)
R-HSA-374696
Reaction Name: Phosphorylation of L1 by p90rsk
See in Reactome
R-HSA-3857328
(
R-HSA-2559582
)
R-HSA-3857328
Reaction Name: RPS6KA1/2/3 phosphorylates CEBPB on S321
See in Reactome
R-HSA-442724
(
R-HSA-442742
)
R-HSA-442724
Reaction Name: Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
See in Reactome
R-HSA-442739
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9029434
Reaction Name: p-S363,S380,T573 RS6K translocates to the nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-442742;
R-HSA-444257
)
R-HSA-9620004
(
R-HSA-442742;
R-HSA-444257
)
|
MONDO:0007963 |
STK11 |
Q15831 |
2.7.11.1
|
R-HSA-163680
R-HSA-163680
Reactome Name: AMPK inhibits chREBP transcriptional activation activity
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-9614085
R-HSA-74160
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-165159
R-HSA-212436
R-HSA-1430728
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism
Signal Transduction
|
R-HSA-164151
(
R-HSA-163680
)
R-HSA-164151
Reaction Name: LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
See in Reactome
R-HSA-200421
(
R-HSA-380972
)
R-HSA-200421
Reaction Name: Activation of cytosolic AMPK by phosphorylation
See in Reactome
R-HSA-3222006
(
R-HSA-6804756
)
R-HSA-3222006
Reaction Name: STK11 (LKB1) phosphorylates NUAK1
See in Reactome
R-HSA-3222020
(
R-HSA-6804756
)
R-HSA-380942
(
R-HSA-380972
)
R-HSA-380942
Reaction Name: LKB1 forms a trimeric complex with STRAD and MO25
See in Reactome
R-HSA-6805035
(
R-HSA-6804756
)
R-HSA-9625378
(
R-HSA-9614657
)
R-HSA-9625378
Reaction Name: STK11 gene transcription is stimulated by FOXO3,FOXO4
See in Reactome
|
MONDO:0018310 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0014418 |
SPEG |
Q15772 |
2.7.11.1
|
|
|
|
|
MONDO:0017148 |
EIF2AK4 |
Q9P2K8 |
2.7.11.1
|
R-HSA-9633012
R-HSA-9633012
Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency
See in Reactome
|
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-8953897
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-9633005
(
R-HSA-9633012
)
R-HSA-9633008
(
R-HSA-9633012
)
R-HSA-9633008
Reaction Name: p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1
See in Reactome
R-HSA-9633742
(
R-HSA-9633012
)
R-HSA-9633742
Reaction Name: EIF2AK4 (GCN2) dimer autophosphorylates
See in Reactome
|
MONDO:0020849 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0008855 |
CIITA |
P33076 |
2.3.1.-
2.7.11.1
|
R-HSA-877300
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
|
Immune System
|
R-HSA-1031716
(
R-HSA-877300
)
R-HSA-1031716
Reaction Name: Expression of IFNG-stimulated genes
See in Reactome
|
MONDO:0005036 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0014892 |
TRIO |
O75962 |
2.7.11.1
|
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-9013423
R-HSA-416476
R-HSA-8980692
R-HSA-9013408
R-HSA-9013409
R-HSA-9013404
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-9013149
R-HSA-9013148
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-372790
R-HSA-9012999
R-HSA-388396
R-HSA-194315
R-HSA-9675108
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1266738
R-HSA-373752
|
Signal Transduction
Developmental Biology
|
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-400586
(
R-HSA-416476
)
R-HSA-400586
Reaction Name: G alpha (q) binds to Trio family RhoGEFs
See in Reactome
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9014296
(
R-HSA-9013404
)
R-HSA-9014433
(
R-HSA-9013408
)
R-HSA-9017491
(
R-HSA-9013409
)
R-HSA-9018804
(
R-HSA-9013423
)
|
MONDO:0012127 |
TTN |
Q8WZ42 |
2.7.11.1
|
R-HSA-390522
R-HSA-114608
|
R-HSA-397014
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-109582
|
Muscle contraction
Hemostasis
|
R-HSA-390593
(
R-HSA-390522
)
R-HSA-390595
(
R-HSA-390522
)
R-HSA-390597
(
R-HSA-390522
)
R-HSA-390598
(
R-HSA-390522
)
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
|
MONDO:0014407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0032655 |
MARK3 |
P27448 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5673000
|
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-5673001
|
Signal Transduction
|
R-HSA-5672948
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672954
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672954
Reaction Name: p-S311,S406 KSR1:MARK3 binds YWHAB dimer
See in Reactome
R-HSA-5672957
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672958
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672958
Reaction Name: YWHAB dimer dissociates from KSR1:MARK3
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674019
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0014596 |
CDK5 |
Q00535 |
2.7.11.1
|
R-HSA-180024
R-HSA-399956
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-9031628
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-166520
R-HSA-162582
R-HSA-212436
R-HSA-418594
R-HSA-111885
R-HSA-9006115
R-HSA-9675108
R-HSA-388396
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-187037
R-HSA-74160
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-372790
R-HSA-109582
R-HSA-1266738
R-HSA-73857
|
Signal Transduction
Gene expression (Transcription)
Hemostasis
Developmental Biology
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-180047
(
R-HSA-180024
)
R-HSA-180047
Reaction Name: CDK5 phosphorylates DARPP-32 on Thr75
See in Reactome
R-HSA-399944
(
R-HSA-399956
)
R-HSA-399944
Reaction Name: Phosphorylation of CRMPs by Cdk5
See in Reactome
R-HSA-399946
(
R-HSA-399956
)
R-HSA-399946
Reaction Name: Recruitment and activation of Cdk5
See in Reactome
R-HSA-399951
(
R-HSA-399956
)
R-HSA-399951
Reaction Name: Phosphorylation of CRMPs by GSK3beta
See in Reactome
R-HSA-6805276
(
R-HSA-6804756
)
R-HSA-9032841
(
R-HSA-9032845
)
R-HSA-9032854
(
R-HSA-9032845
)
R-HSA-9032863
(
R-HSA-9032845
)
R-HSA-9616368
(
R-HSA-9031628
)
|
MONDO:0007295 |
SIK1B |
A0A0B4J2F2 |
2.7.11.1
|
|
|
|
|
MONDO:0032648 |
MAST1 |
Q9Y2H9 |
2.7.11.1
|
|
|
|
|
MONDO:0002629 |
MONDO:0002629
Disease Name: bone osteosarcoma
OMIM id: OMIM:259500
Orphanet id: Orphanet:668
All associated enzymes in DAR:
CHEK2
. The disease is also associated to other non-enzyme proteins (not in DAR).
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0011866 |
VRK1 |
Q99986 |
2.7.11.1
|
R-HSA-2995383
R-HSA-2995383
Reactome Name: Initiation of Nuclear Envelope (NE) Reformation
See in Reactome
R-HSA-2980766
|
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-2995410
R-HSA-2995410
Reactome Name: Nuclear Envelope (NE) Reassembly
See in Reactome
R-HSA-68875
|
Cell Cycle
|
R-HSA-2993898
(
R-HSA-2980766
)
R-HSA-2995389
(
R-HSA-2995383
)
|
MONDO:0013380 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0010480 |
CASK |
O14936 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
R-HSA-212676
R-HSA-212676
Reactome Name: Dopamine Neurotransmitter Release Cycle
See in Reactome
R-HSA-6794361
R-HSA-3000170
R-HSA-373753
R-HSA-9609736
R-HSA-9609736
Reactome Name: Assembly and cell surface presentation of NMDA receptors
See in Reactome
|
R-HSA-9659379
R-HSA-1500931
R-HSA-9709957
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-3000171
R-HSA-3000171
Reactome Name: Non-integrin membrane-ECM interactions
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-112310
|
Cell-Cell communication
Sensory Perception
Extracellular matrix organization
Neuronal System
|
R-HSA-2750181
(
R-HSA-3000170
)
R-HSA-373722
(
R-HSA-373753
)
R-HSA-380574
(
R-HSA-212676
)
R-HSA-380574
Reaction Name: Dopamine synaptic vesicle docking and priming
See in Reactome
R-HSA-5336443
(
R-HSA-212676
)
R-HSA-6794352
(
R-HSA-6794361
)
R-HSA-6794352
Reaction Name: NRXNs binds CASK tripartite complex
See in Reactome
R-HSA-6797553
(
R-HSA-6794361
)
R-HSA-6797568
(
R-HSA-6794361
)
R-HSA-9610408
(
R-HSA-9609736
)
R-HSA-9610408
Reaction Name: GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17
See in Reactome
R-HSA-9610627
(
R-HSA-9609736
)
R-HSA-9610627
Reaction Name: KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
See in Reactome
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0030018 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-2672351;
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0100062 |
CASK |
O14936 |
2.7.11.1
|
R-HSA-9662361
R-HSA-9662361
Reactome Name: Sensory processing of sound by outer hair cells of the cochlea
See in Reactome
R-HSA-9662360
R-HSA-9662360
Reactome Name: Sensory processing of sound by inner hair cells of the cochlea
See in Reactome
R-HSA-212676
R-HSA-212676
Reactome Name: Dopamine Neurotransmitter Release Cycle
See in Reactome
R-HSA-6794361
R-HSA-3000170
R-HSA-373753
R-HSA-9609736
R-HSA-9609736
Reactome Name: Assembly and cell surface presentation of NMDA receptors
See in Reactome
|
R-HSA-9659379
R-HSA-1500931
R-HSA-9709957
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-6794362
R-HSA-6794362
Reactome Name: Protein-protein interactions at synapses
See in Reactome
R-HSA-3000171
R-HSA-3000171
Reactome Name: Non-integrin membrane-ECM interactions
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-112310
|
Cell-Cell communication
Sensory Perception
Extracellular matrix organization
Neuronal System
|
R-HSA-2750181
(
R-HSA-3000170
)
R-HSA-373722
(
R-HSA-373753
)
R-HSA-380574
(
R-HSA-212676
)
R-HSA-380574
Reaction Name: Dopamine synaptic vesicle docking and priming
See in Reactome
R-HSA-5336443
(
R-HSA-212676
)
R-HSA-6794352
(
R-HSA-6794361
)
R-HSA-6794352
Reaction Name: NRXNs binds CASK tripartite complex
See in Reactome
R-HSA-6797553
(
R-HSA-6794361
)
R-HSA-6797568
(
R-HSA-6794361
)
R-HSA-9610408
(
R-HSA-9609736
)
R-HSA-9610408
Reaction Name: GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17
See in Reactome
R-HSA-9610627
(
R-HSA-9609736
)
R-HSA-9610627
Reaction Name: KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
See in Reactome
R-HSA-9659380
(
R-HSA-9662360
)
R-HSA-9659380
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell
See in Reactome
R-HSA-9663363
(
R-HSA-9662361
)
R-HSA-9663363
Reaction Name: Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell
See in Reactome
|
MONDO:0016642 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014423 |
PRKDC |
P78527 |
2.7.11.1
|
R-HSA-3270619
R-HSA-3270619
Reactome Name: IRF3-mediated induction of type I IFN
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
R-HSA-8852135
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1834941
R-HSA-1834941
Reactome Name: STING mediated induction of host immune responses
See in Reactome
|
Immune System
Metabolism of proteins
DNA Repair
|
R-HSA-1834939
(
R-HSA-1834949;
R-HSA-3270619
)
R-HSA-3134821
(
R-HSA-1834949
)
R-HSA-5686924
(
R-HSA-5693571
)
R-HSA-5686924
Reaction Name: DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
See in Reactome
R-HSA-5687183
(
R-HSA-5693571
)
R-HSA-5687183
Reaction Name: PRKDC phosphorylates DCLRE1C at DNA DSBs
See in Reactome
R-HSA-5687360
(
R-HSA-5693571
)
R-HSA-5687360
Reaction Name: POLL or POLM extends aligned DNA DSB ends to fill gaps
See in Reactome
R-HSA-5693533
(
R-HSA-5693571
)
R-HSA-5693533
Reaction Name: DCLRE1C (ARTEMIS) processes DNA DSB ends
See in Reactome
R-HSA-5693574
(
R-HSA-5693571
)
R-HSA-5693574
Reaction Name: XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ
See in Reactome
R-HSA-5693575
(
R-HSA-5693571
)
R-HSA-5693578
(
R-HSA-5693571
)
R-HSA-5693578
Reaction Name: TDP1 and TDP2 process unligatable DSB ends
See in Reactome
R-HSA-5693604
(
R-HSA-5693571
)
R-HSA-5693604
Reaction Name: XRCC4:LIG4 ligates DNA DSB ends during NHEJ
See in Reactome
R-HSA-5693615
(
R-HSA-5693571
)
R-HSA-5693615
Reaction Name: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis
See in Reactome
R-HSA-8938770
(
R-HSA-8866654
)
R-HSA-8938770
Reaction Name: RNF144A binds PRKDC and Ubiquitin:UBE2L3
See in Reactome
R-HSA-8938773
(
R-HSA-8866654
)
R-HSA-8938773
Reaction Name: RNF144A polyubiquitinates PRKDC
See in Reactome
|
MONDO:0009693 |
AURKA |
O14965 |
2.7.11.1
|
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8854521
R-HSA-8854521
Reactome Name: Interaction between PHLDA1 and AURKA
See in Reactome
R-HSA-8854518
R-HSA-6804114
R-HSA-6804114
Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
See in Reactome
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69278
R-HSA-6791312
R-HSA-6791312
Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes
See in Reactome
R-HSA-2990846
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-69275
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
|
R-HSA-174088
(
R-HSA-174178
)
R-HSA-174088
Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174195
(
R-HSA-174178
)
R-HSA-174195
Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-4655404
(
R-HSA-4615885
)
R-HSA-4655404
Reaction Name: SUMOylation of AURKA with SUMO1
See in Reactome
R-HSA-6791235
(
R-HSA-6804114
)
R-HSA-6805103
(
R-HSA-6804756
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8853429
(
R-HSA-8854521
)
R-HSA-8853444
(
R-HSA-8854521
)
R-HSA-8853496
(
R-HSA-8854050
)
R-HSA-8854041
(
R-HSA-8854050
)
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
|
MONDO:0011508 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0008170 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0007963 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0012233 |
CHEK2 |
O96017 |
2.7.11.1
|
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-69541
R-HSA-75035
R-HSA-75035
Reactome Name: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-73894
R-HSA-5633007
R-HSA-69615
R-HSA-69481
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-69620
R-HSA-212436
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1640170
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Cell Cycle
|
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683774
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683792
Reaction Name: p-T68-CHEK2 autophosphorylates
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-6804266
(
R-HSA-6804760
)
R-HSA-69608
(
R-HSA-69601
)
R-HSA-69608
Reaction Name: Phosphorylation of Cdc25A at Ser-123 by Chk2
See in Reactome
R-HSA-69685
(
R-HSA-6804756;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-75809
(
R-HSA-69473;
R-HSA-75035
)
R-HSA-75809
Reaction Name: Phosphorylation of Cdc25C at Ser216 by CHEK2
See in Reactome
|
MONDO:0013777 |
WNK4 |
Q96J92 |
2.7.11.1
|
R-HSA-2672351
|
R-HSA-983712
R-HSA-382551
|
Transport of small molecules
|
R-HSA-2682349
(
R-HSA-2672351
)
R-HSA-2682349
Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
See in Reactome
|