MONDO:0005029 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0005292 |
MONDO:0005292
Disease Name: colitis
OMIM id: OMIM:191390
All associated enzymes in DAR:
SYK
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0005298 |
MONDO:0005298
Disease Name: osteoporosis
OMIM id: OMIM:166710
All associated enzymes in DAR:
SRC
. The disease is also associated to other non-enzyme proteins (not in DAR).
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0005453 |
ABL1 |
P00519 |
2.7.10.2
|
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-428890
R-HSA-428890
Reactome Name: Role of ABL in ROBO-SLIT signaling
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-525793
|
R-HSA-376176
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-168249
R-HSA-422475
R-HSA-195258
R-HSA-5693538
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
DNA Repair
Hemostasis
Signal Transduction
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376141
(
R-HSA-428890
)
R-HSA-376141
Reaction Name: Interaction of ABL with ROBO1:SLIT2
See in Reactome
R-HSA-428883
(
R-HSA-428890
)
R-HSA-428885
(
R-HSA-428890
)
R-HSA-428888
(
R-HSA-428890
)
R-HSA-428888
Reaction Name: Phosphorylation of ROBO1 by ABL kinase
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686587
(
R-HSA-5685938
)
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8956639
(
R-HSA-8939236
)
R-HSA-8956659
(
R-HSA-8939236
)
R-HSA-8985227
(
R-HSA-8940973
)
R-HSA-8985227
Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0005578 |
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0006547 |
MONDO:0006547
Disease Name: exanthem
All associated enzymes in DAR:
SYK
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0007572 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0007915 |
BLK |
P51451 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-8939245
R-HSA-8939245
Reactome Name: RUNX1 regulates transcription of genes involved in BCR signaling
See in Reactome
|
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-73857
|
Gene expression (Transcription)
Immune System
|
R-HSA-8938987
(
R-HSA-8939245
)
R-HSA-8938987
Reaction Name: BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5
See in Reactome
R-HSA-983709
(
R-HSA-983695
)
R-HSA-983709
Reaction Name: LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
See in Reactome
|
MONDO:0009539 |
ABL1 |
P00519 |
2.7.10.2
|
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-428890
R-HSA-428890
Reactome Name: Role of ABL in ROBO-SLIT signaling
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-525793
|
R-HSA-376176
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-168249
R-HSA-422475
R-HSA-195258
R-HSA-5693538
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
DNA Repair
Hemostasis
Signal Transduction
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376141
(
R-HSA-428890
)
R-HSA-376141
Reaction Name: Interaction of ABL with ROBO1:SLIT2
See in Reactome
R-HSA-428883
(
R-HSA-428890
)
R-HSA-428885
(
R-HSA-428890
)
R-HSA-428888
(
R-HSA-428890
)
R-HSA-428888
Reaction Name: Phosphorylation of ROBO1 by ABL kinase
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686587
(
R-HSA-5685938
)
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8956639
(
R-HSA-8939236
)
R-HSA-8956659
(
R-HSA-8939236
)
R-HSA-8985227
(
R-HSA-8940973
)
R-HSA-8985227
Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
See in Reactome
|
MONDO:0009539 |
JAK1 |
P23458 |
2.7.10.2
|
R-HSA-8984722
R-HSA-1169408
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-9020956
R-HSA-9020958
R-HSA-5673001
R-HSA-1266695
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-8985947
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-8983432
R-HSA-6783783
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-449836
R-HSA-9674555
R-HSA-112411
R-HSA-877312
R-HSA-9020558
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-913531
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-5684996
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-9677585
(
R-HSA-9674555
)
R-HSA-9677585
Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1
See in Reactome
R-HSA-909720
(
R-HSA-909733
)
R-HSA-8987266
(
R-HSA-8854691
)
R-HSA-8987266
Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
See in Reactome
R-HSA-448708
(
R-HSA-8854691
)
R-HSA-448708
Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-8983335
(
R-HSA-8983432
)
R-HSA-8983335
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
See in Reactome
R-HSA-8985988
(
R-HSA-8985947
)
R-HSA-8985988
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-6784319
(
R-HSA-6783783
)
R-HSA-6784319
Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2
See in Reactome
R-HSA-8987105
(
R-HSA-8854691
)
R-HSA-8987105
Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-451900
(
R-HSA-9020558
)
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-8987015
(
R-HSA-8854691
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-452091
(
R-HSA-9020558
)
R-HSA-452091
Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment
See in Reactome
R-HSA-8854645
(
R-HSA-8854691
)
R-HSA-8854645
Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-9006873
(
R-HSA-9020958
)
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-9025969
(
R-HSA-1266695
)
R-HSA-9025969
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
See in Reactome
R-HSA-9005980
(
R-HSA-9020958
)
R-HSA-912680
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-912680
Reaction Name: Inhibition of JAK kinase activity by SOCS1/3
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-448661
(
R-HSA-449836;
R-HSA-8854691
)
R-HSA-448661
Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-449811
(
R-HSA-6783783
)
R-HSA-449811
Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-8987270
(
R-HSA-8854691
)
R-HSA-8987270
Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9674558
(
R-HSA-9674555
)
R-HSA-9674558
Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
See in Reactome
R-HSA-8982165
(
R-HSA-8854691
)
R-HSA-8982165
Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-9678935
(
R-HSA-909733
)
R-HSA-9678935
Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8983374
(
R-HSA-8983432
)
R-HSA-8983374
Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
See in Reactome
R-HSA-8987080
(
R-HSA-8854691
)
R-HSA-8987080
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
See in Reactome
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8987039
(
R-HSA-8854691
)
R-HSA-508247
(
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-8986480
(
R-HSA-8854691
)
R-HSA-8986480
Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-8985929
(
R-HSA-8985947
)
R-HSA-8985929
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8983425
(
R-HSA-8983432
)
R-HSA-8983425
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
See in Reactome
R-HSA-6784791
(
R-HSA-6783783
)
R-HSA-6784791
Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8987040
(
R-HSA-8854691
)
R-HSA-8987040
Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
See in Reactome
R-HSA-909718
(
R-HSA-909733
)
R-HSA-449803
(
R-HSA-6783783
)
R-HSA-8987161
(
R-HSA-8854691
)
R-HSA-8987161
Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3
See in Reactome
R-HSA-8987129
(
R-HSA-8854691
)
R-HSA-8987129
Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-6784006
(
R-HSA-6783783
)
R-HSA-6784006
Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
See in Reactome
R-HSA-452108
(
R-HSA-9020558
)
R-HSA-452108
Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-909729
(
R-HSA-909733
)
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-8983371
(
R-HSA-8983432
)
R-HSA-8983371
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
R-HSA-997314
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997314
Reaction Name: Dephosphorylation of JAK1 by SHP1
See in Reactome
R-HSA-873918
(
R-HSA-877300
)
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-6784324
(
R-HSA-6783783
)
R-HSA-6784324
Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
See in Reactome
R-HSA-450063
(
R-HSA-9020558
)
R-HSA-450063
Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
See in Reactome
R-HSA-8982162
(
R-HSA-8854691
)
R-HSA-8982162
Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
See in Reactome
R-HSA-8963734
(
R-HSA-8985947
)
R-HSA-8963734
Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-8987120
(
R-HSA-8854691
)
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-452097
(
R-HSA-9020558
)
R-HSA-452097
Reaction Name: Recruited STAT5 is phosphorylated
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8983298
(
R-HSA-8983432
)
R-HSA-8983298
Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-448480
(
R-HSA-8854691
)
R-HSA-448480
Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-909730
(
R-HSA-909733
)
R-HSA-909730
Reaction Name: Phosphorylation of INFAR1 by TYK2
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-919404
(
R-HSA-9020558
)
R-HSA-919404
Reaction Name: Phosphorylated STAT5 is released
See in Reactome
R-HSA-8986972
(
R-HSA-8854691
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8983424
(
R-HSA-8983432
)
R-HSA-8983424
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-9009700
(
R-HSA-8983432
)
R-HSA-9009700
Reaction Name: IL2RB and IL2RG are phosphorylated
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-8983394
(
R-HSA-8983432
)
R-HSA-8983394
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
See in Reactome
R-HSA-9677579
(
R-HSA-9674555
)
R-HSA-9677579
Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
See in Reactome
R-HSA-8986994
(
R-HSA-8854691
)
R-HSA-8986994
Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-449958
(
R-HSA-1266695
)
R-HSA-8950716
(
R-HSA-9020956
)
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-1264832
(
R-HSA-1266695
)
R-HSA-8987202
(
R-HSA-8854691
)
R-HSA-8987202
Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-909724
(
R-HSA-909733
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-8987097
(
R-HSA-8854691
)
R-HSA-8987097
Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3
See in Reactome
R-HSA-997311
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997311
Reaction Name: Dephosphorylation of TYK2 by PTP1B
See in Reactome
R-HSA-8987042
(
R-HSA-8854691
)
R-HSA-8987042
Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-448744
(
R-HSA-8854691
)
R-HSA-8986446
(
R-HSA-8854691
)
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-8985900
(
R-HSA-8985947
)
R-HSA-8985900
Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
See in Reactome
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-8987012
(
R-HSA-8854691
)
R-HSA-8987012
Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-909719
(
R-HSA-909733
)
R-HSA-909719
Reaction Name: Recruitment of STAT2 to p-IFNAR1
See in Reactome
R-HSA-912527
(
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-9006844
(
R-HSA-9020958
)
R-HSA-9006844
Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-909732
(
R-HSA-909733
)
R-HSA-9009227
(
R-HSA-8854691
)
R-HSA-9009227
Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-6785165
(
R-HSA-1266695
)
R-HSA-6785165
Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
See in Reactome
R-HSA-913424
(
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-1295540
(
R-HSA-1266695
)
R-HSA-1295540
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-8983063
(
R-HSA-1266695
)
R-HSA-8983063
Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
See in Reactome
R-HSA-8982163
(
R-HSA-8854691
)
R-HSA-8982163
Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-450027
(
R-HSA-9020558
)
R-HSA-450027
Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
See in Reactome
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-8987255
(
R-HSA-8854691
)
R-HSA-8987255
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
See in Reactome
R-HSA-1295519
(
R-HSA-1266695
)
R-HSA-1295519
Reaction Name: IL7R is phosphorylated on Y499
See in Reactome
R-HSA-448728
(
R-HSA-8854691
)
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8987084
(
R-HSA-8854691
)
R-HSA-8987084
Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-8983003
(
R-HSA-1266695
)
R-HSA-8983003
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
See in Reactome
R-HSA-449978
(
R-HSA-1266695
)
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9011748
(
R-HSA-8985947
)
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-6784323
(
R-HSA-6783783
)
R-HSA-6784323
Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
See in Reactome
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-453104
(
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-449115
(
R-HSA-8983432
)
R-HSA-449115
Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987063
(
R-HSA-8854691
)
R-HSA-8987063
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-8987043
(
R-HSA-8854691
)
R-HSA-8983384
(
R-HSA-8983432
)
R-HSA-8983384
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
See in Reactome
R-HSA-913374
(
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-9006850
(
R-HSA-9020958
)
R-HSA-9006850
Reaction Name: IL21 receptor JAK phosphorylation
See in Reactome
R-HSA-8987150
(
R-HSA-8854691
)
R-HSA-8987150
Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-8983300
(
R-HSA-8983432
)
R-HSA-8983300
Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8987096
(
R-HSA-8854691
)
R-HSA-8987096
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-8986995
(
R-HSA-8854691
)
R-HSA-8986995
Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
See in Reactome
R-HSA-8986985
(
R-HSA-8854691
)
R-HSA-8986985
Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-452122
(
R-HSA-9020558
)
R-HSA-452122
Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
See in Reactome
R-HSA-909722
(
R-HSA-909733
)
R-HSA-909722
Reaction Name: Release of p-STAT2:p-STAT1 dimer
See in Reactome
R-HSA-8987033
(
R-HSA-8854691
)
R-HSA-8987033
Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
See in Reactome
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-8983309
(
R-HSA-8983432
)
R-HSA-8983309
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
See in Reactome
R-HSA-448660
(
R-HSA-6788467
)
R-HSA-448660
Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-8985973
(
R-HSA-8985947
)
R-HSA-8985973
Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
See in Reactome
R-HSA-451942
(
R-HSA-9020558
)
R-HSA-451942
Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1
See in Reactome
R-HSA-9006870
(
R-HSA-9020958
)
R-HSA-9006870
Reaction Name: IL21 receptor STAT phosphorylation
See in Reactome
R-HSA-8985914
(
R-HSA-8985947
)
R-HSA-8985914
Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-8983299
(
R-HSA-8983432
)
R-HSA-8983299
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-8983378
(
R-HSA-8983432
)
R-HSA-8983378
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
See in Reactome
R-HSA-453111
(
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-8987230
(
R-HSA-8854691
)
R-HSA-8987230
Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1295516
(
R-HSA-1266695
)
R-HSA-1295516
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-9674546
(
R-HSA-9674555
)
R-HSA-9674546
Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
See in Reactome
|
MONDO:0009692 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0009692 |
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0009891 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0009891 |
JAK1 |
P23458 |
2.7.10.2
|
R-HSA-8984722
R-HSA-1169408
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-9020956
R-HSA-9020958
R-HSA-5673001
R-HSA-1266695
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-8985947
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-8983432
R-HSA-6783783
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-449836
R-HSA-9674555
R-HSA-112411
R-HSA-877312
R-HSA-9020558
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-913531
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-5684996
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-9677585
(
R-HSA-9674555
)
R-HSA-9677585
Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1
See in Reactome
R-HSA-909720
(
R-HSA-909733
)
R-HSA-8987266
(
R-HSA-8854691
)
R-HSA-8987266
Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
See in Reactome
R-HSA-448708
(
R-HSA-8854691
)
R-HSA-448708
Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-8983335
(
R-HSA-8983432
)
R-HSA-8983335
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
See in Reactome
R-HSA-8985988
(
R-HSA-8985947
)
R-HSA-8985988
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-6784319
(
R-HSA-6783783
)
R-HSA-6784319
Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2
See in Reactome
R-HSA-8987105
(
R-HSA-8854691
)
R-HSA-8987105
Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-451900
(
R-HSA-9020558
)
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-8987015
(
R-HSA-8854691
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-452091
(
R-HSA-9020558
)
R-HSA-452091
Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment
See in Reactome
R-HSA-8854645
(
R-HSA-8854691
)
R-HSA-8854645
Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-9006873
(
R-HSA-9020958
)
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-9025969
(
R-HSA-1266695
)
R-HSA-9025969
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
See in Reactome
R-HSA-9005980
(
R-HSA-9020958
)
R-HSA-912680
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-912680
Reaction Name: Inhibition of JAK kinase activity by SOCS1/3
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-448661
(
R-HSA-449836;
R-HSA-8854691
)
R-HSA-448661
Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-449811
(
R-HSA-6783783
)
R-HSA-449811
Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-8987270
(
R-HSA-8854691
)
R-HSA-8987270
Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9674558
(
R-HSA-9674555
)
R-HSA-9674558
Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
See in Reactome
R-HSA-8982165
(
R-HSA-8854691
)
R-HSA-8982165
Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-9678935
(
R-HSA-909733
)
R-HSA-9678935
Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8983374
(
R-HSA-8983432
)
R-HSA-8983374
Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
See in Reactome
R-HSA-8987080
(
R-HSA-8854691
)
R-HSA-8987080
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
See in Reactome
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8987039
(
R-HSA-8854691
)
R-HSA-508247
(
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-8986480
(
R-HSA-8854691
)
R-HSA-8986480
Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-8985929
(
R-HSA-8985947
)
R-HSA-8985929
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8983425
(
R-HSA-8983432
)
R-HSA-8983425
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
See in Reactome
R-HSA-6784791
(
R-HSA-6783783
)
R-HSA-6784791
Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8987040
(
R-HSA-8854691
)
R-HSA-8987040
Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
See in Reactome
R-HSA-909718
(
R-HSA-909733
)
R-HSA-449803
(
R-HSA-6783783
)
R-HSA-8987161
(
R-HSA-8854691
)
R-HSA-8987161
Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3
See in Reactome
R-HSA-8987129
(
R-HSA-8854691
)
R-HSA-8987129
Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-6784006
(
R-HSA-6783783
)
R-HSA-6784006
Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
See in Reactome
R-HSA-452108
(
R-HSA-9020558
)
R-HSA-452108
Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-909729
(
R-HSA-909733
)
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-8983371
(
R-HSA-8983432
)
R-HSA-8983371
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
R-HSA-997314
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997314
Reaction Name: Dephosphorylation of JAK1 by SHP1
See in Reactome
R-HSA-873918
(
R-HSA-877300
)
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-6784324
(
R-HSA-6783783
)
R-HSA-6784324
Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
See in Reactome
R-HSA-450063
(
R-HSA-9020558
)
R-HSA-450063
Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
See in Reactome
R-HSA-8982162
(
R-HSA-8854691
)
R-HSA-8982162
Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
See in Reactome
R-HSA-8963734
(
R-HSA-8985947
)
R-HSA-8963734
Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-8987120
(
R-HSA-8854691
)
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-452097
(
R-HSA-9020558
)
R-HSA-452097
Reaction Name: Recruited STAT5 is phosphorylated
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8983298
(
R-HSA-8983432
)
R-HSA-8983298
Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-448480
(
R-HSA-8854691
)
R-HSA-448480
Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-909730
(
R-HSA-909733
)
R-HSA-909730
Reaction Name: Phosphorylation of INFAR1 by TYK2
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-919404
(
R-HSA-9020558
)
R-HSA-919404
Reaction Name: Phosphorylated STAT5 is released
See in Reactome
R-HSA-8986972
(
R-HSA-8854691
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8983424
(
R-HSA-8983432
)
R-HSA-8983424
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-9009700
(
R-HSA-8983432
)
R-HSA-9009700
Reaction Name: IL2RB and IL2RG are phosphorylated
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-8983394
(
R-HSA-8983432
)
R-HSA-8983394
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
See in Reactome
R-HSA-9677579
(
R-HSA-9674555
)
R-HSA-9677579
Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
See in Reactome
R-HSA-8986994
(
R-HSA-8854691
)
R-HSA-8986994
Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-449958
(
R-HSA-1266695
)
R-HSA-8950716
(
R-HSA-9020956
)
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-1264832
(
R-HSA-1266695
)
R-HSA-8987202
(
R-HSA-8854691
)
R-HSA-8987202
Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-909724
(
R-HSA-909733
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-8987097
(
R-HSA-8854691
)
R-HSA-8987097
Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3
See in Reactome
R-HSA-997311
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997311
Reaction Name: Dephosphorylation of TYK2 by PTP1B
See in Reactome
R-HSA-8987042
(
R-HSA-8854691
)
R-HSA-8987042
Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-448744
(
R-HSA-8854691
)
R-HSA-8986446
(
R-HSA-8854691
)
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-8985900
(
R-HSA-8985947
)
R-HSA-8985900
Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
See in Reactome
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-8987012
(
R-HSA-8854691
)
R-HSA-8987012
Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-909719
(
R-HSA-909733
)
R-HSA-909719
Reaction Name: Recruitment of STAT2 to p-IFNAR1
See in Reactome
R-HSA-912527
(
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-9006844
(
R-HSA-9020958
)
R-HSA-9006844
Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-909732
(
R-HSA-909733
)
R-HSA-9009227
(
R-HSA-8854691
)
R-HSA-9009227
Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-6785165
(
R-HSA-1266695
)
R-HSA-6785165
Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
See in Reactome
R-HSA-913424
(
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-1295540
(
R-HSA-1266695
)
R-HSA-1295540
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-8983063
(
R-HSA-1266695
)
R-HSA-8983063
Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
See in Reactome
R-HSA-8982163
(
R-HSA-8854691
)
R-HSA-8982163
Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-450027
(
R-HSA-9020558
)
R-HSA-450027
Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
See in Reactome
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-8987255
(
R-HSA-8854691
)
R-HSA-8987255
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
See in Reactome
R-HSA-1295519
(
R-HSA-1266695
)
R-HSA-1295519
Reaction Name: IL7R is phosphorylated on Y499
See in Reactome
R-HSA-448728
(
R-HSA-8854691
)
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8987084
(
R-HSA-8854691
)
R-HSA-8987084
Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-8983003
(
R-HSA-1266695
)
R-HSA-8983003
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
See in Reactome
R-HSA-449978
(
R-HSA-1266695
)
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9011748
(
R-HSA-8985947
)
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-6784323
(
R-HSA-6783783
)
R-HSA-6784323
Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
See in Reactome
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-453104
(
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-449115
(
R-HSA-8983432
)
R-HSA-449115
Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987063
(
R-HSA-8854691
)
R-HSA-8987063
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-8987043
(
R-HSA-8854691
)
R-HSA-8983384
(
R-HSA-8983432
)
R-HSA-8983384
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
See in Reactome
R-HSA-913374
(
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-9006850
(
R-HSA-9020958
)
R-HSA-9006850
Reaction Name: IL21 receptor JAK phosphorylation
See in Reactome
R-HSA-8987150
(
R-HSA-8854691
)
R-HSA-8987150
Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-8983300
(
R-HSA-8983432
)
R-HSA-8983300
Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8987096
(
R-HSA-8854691
)
R-HSA-8987096
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-8986995
(
R-HSA-8854691
)
R-HSA-8986995
Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
See in Reactome
R-HSA-8986985
(
R-HSA-8854691
)
R-HSA-8986985
Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-452122
(
R-HSA-9020558
)
R-HSA-452122
Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
See in Reactome
R-HSA-909722
(
R-HSA-909733
)
R-HSA-909722
Reaction Name: Release of p-STAT2:p-STAT1 dimer
See in Reactome
R-HSA-8987033
(
R-HSA-8854691
)
R-HSA-8987033
Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
See in Reactome
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-8983309
(
R-HSA-8983432
)
R-HSA-8983309
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
See in Reactome
R-HSA-448660
(
R-HSA-6788467
)
R-HSA-448660
Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-8985973
(
R-HSA-8985947
)
R-HSA-8985973
Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
See in Reactome
R-HSA-451942
(
R-HSA-9020558
)
R-HSA-451942
Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1
See in Reactome
R-HSA-9006870
(
R-HSA-9020958
)
R-HSA-9006870
Reaction Name: IL21 receptor STAT phosphorylation
See in Reactome
R-HSA-8985914
(
R-HSA-8985947
)
R-HSA-8985914
Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-8983299
(
R-HSA-8983432
)
R-HSA-8983299
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-8983378
(
R-HSA-8983432
)
R-HSA-8983378
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
See in Reactome
R-HSA-453111
(
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-8987230
(
R-HSA-8854691
)
R-HSA-8987230
Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1295516
(
R-HSA-1266695
)
R-HSA-1295516
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-9674546
(
R-HSA-9674555
)
R-HSA-9674546
Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
See in Reactome
|
MONDO:0010023 |
ZAP70 |
P43403 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-9013407
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
|
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-202403
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
|
MONDO:0010421 |
BTK |
Q06187 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-1236974
R-HSA-416476
R-HSA-2424491
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-8964315
R-HSA-8964315
Reactome Name: G beta:gamma signalling through BTK
See in Reactome
|
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-194315
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-168256
R-HSA-168898
R-HSA-195258
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-2172127
R-HSA-168249
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-388396
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-166072
(
R-HSA-166058
)
R-HSA-166072
Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4
See in Reactome
R-HSA-166082
(
R-HSA-166058
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-2197698
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2201322
(
R-HSA-166058
)
R-HSA-2201322
Reaction Name: TIRAP is phosphorylated by BTK
See in Reactome
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2424481
(
R-HSA-2424491
)
R-HSA-2424481
Reaction Name: Recruitment of VAV and BTK to p-SLP-76
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424485
(
R-HSA-2424491
)
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2559414
(
R-HSA-166058
)
R-HSA-2559414
Reaction Name: Activated TLR2/4:TIRAP interacts with BTK
See in Reactome
R-HSA-2730833
(
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730847
(
R-HSA-2871809
)
R-HSA-2730858
(
R-HSA-2871809
)
R-HSA-2730858
Reaction Name: Autophosphorylation of BTK/ITK
See in Reactome
R-HSA-2730885
(
R-HSA-2871809
)
R-HSA-2730885
Reaction Name: Recruitment of TEC kinases to p-SLP-76
See in Reactome
R-HSA-2730888
(
R-HSA-2871809
)
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-8964241
(
R-HSA-8964315
)
R-HSA-8964241
Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane
See in Reactome
R-HSA-8964246
(
R-HSA-416482
)
R-HSA-8964246
Reaction Name: BTK in G alpha (12)-BTK complex is activated
See in Reactome
R-HSA-8964271
(
R-HSA-8964315
)
R-HSA-8964271
Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated
See in Reactome
R-HSA-8964274
(
R-HSA-416482
)
R-HSA-8964280
(
R-HSA-416476
)
R-HSA-8964284
(
R-HSA-416476
)
R-HSA-8964284
Reaction Name: BTK in active Gq-BTK complex is activated
See in Reactome
R-HSA-8964317
(
R-HSA-8964315
)
R-HSA-8964317
Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
See in Reactome
R-HSA-8964333
(
R-HSA-416482
)
R-HSA-8964333
Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
See in Reactome
R-HSA-8964340
(
R-HSA-416476
)
R-HSA-8964340
Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq
See in Reactome
R-HSA-937022
(
R-HSA-166058
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-937079
(
R-HSA-166058
)
R-HSA-937079
Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
See in Reactome
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
|
MONDO:0010938 |
JAK3 |
P52333 |
2.7.10.2
|
R-HSA-8985947
R-HSA-1266695
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-8983432
R-HSA-201556
R-HSA-9020558
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020958
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-5673001
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-451927
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-1295516
(
R-HSA-1266695
)
R-HSA-1295516
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
See in Reactome
R-HSA-1295519
(
R-HSA-1266695
)
R-HSA-1295519
Reaction Name: IL7R is phosphorylated on Y499
See in Reactome
R-HSA-1295540
(
R-HSA-1266695
)
R-HSA-1295540
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
See in Reactome
R-HSA-449115
(
R-HSA-8983432
)
R-HSA-449115
Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-449958
(
R-HSA-1266695
)
R-HSA-450063
(
R-HSA-9020558
)
R-HSA-450063
Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
See in Reactome
R-HSA-451895
(
R-HSA-1266695;
R-HSA-6785807;
R-HSA-8985947;
R-HSA-9020558
)
R-HSA-451942
(
R-HSA-9020558
)
R-HSA-451942
Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1
See in Reactome
R-HSA-452091
(
R-HSA-9020558
)
R-HSA-452091
Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment
See in Reactome
R-HSA-452097
(
R-HSA-9020558
)
R-HSA-452097
Reaction Name: Recruited STAT5 is phosphorylated
See in Reactome
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-452108
(
R-HSA-9020558
)
R-HSA-452108
Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
See in Reactome
R-HSA-452122
(
R-HSA-9020558
)
R-HSA-452122
Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
See in Reactome
R-HSA-453104
(
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-453111
(
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-508247
(
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-508451
(
R-HSA-9020558
)
R-HSA-508513
(
R-HSA-9020558
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785165
(
R-HSA-1266695
)
R-HSA-6785165
Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
See in Reactome
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-8963734
(
R-HSA-8985947
)
R-HSA-8963734
Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8983003
(
R-HSA-1266695
)
R-HSA-8983003
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
See in Reactome
R-HSA-8983063
(
R-HSA-1266695
)
R-HSA-8983063
Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
See in Reactome
R-HSA-8983298
(
R-HSA-8983432
)
R-HSA-8983298
Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8983299
(
R-HSA-8983432
)
R-HSA-8983299
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1
See in Reactome
R-HSA-8983300
(
R-HSA-8983432
)
R-HSA-8983300
Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
See in Reactome
R-HSA-8983309
(
R-HSA-8983432
)
R-HSA-8983309
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
See in Reactome
R-HSA-8983335
(
R-HSA-8983432
)
R-HSA-8983335
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
See in Reactome
R-HSA-8983371
(
R-HSA-8983432
)
R-HSA-8983371
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
See in Reactome
R-HSA-8983374
(
R-HSA-8983432
)
R-HSA-8983374
Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
See in Reactome
R-HSA-8983378
(
R-HSA-8983432
)
R-HSA-8983378
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
See in Reactome
R-HSA-8983384
(
R-HSA-8983432
)
R-HSA-8983384
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
See in Reactome
R-HSA-8983394
(
R-HSA-8983432
)
R-HSA-8983394
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
See in Reactome
R-HSA-8983424
(
R-HSA-8983432
)
R-HSA-8983424
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
See in Reactome
R-HSA-8983425
(
R-HSA-8983432
)
R-HSA-8983425
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
See in Reactome
R-HSA-8985900
(
R-HSA-8985947
)
R-HSA-8985900
Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
See in Reactome
R-HSA-8985914
(
R-HSA-8985947
)
R-HSA-8985914
Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
See in Reactome
R-HSA-8985929
(
R-HSA-8985947
)
R-HSA-8985929
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
See in Reactome
R-HSA-8985973
(
R-HSA-8985947
)
R-HSA-8985973
Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
See in Reactome
R-HSA-8985988
(
R-HSA-8985947
)
R-HSA-8985988
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-9006844
(
R-HSA-9020958
)
R-HSA-9006844
Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3
See in Reactome
R-HSA-9006850
(
R-HSA-9020958
)
R-HSA-9006850
Reaction Name: IL21 receptor JAK phosphorylation
See in Reactome
R-HSA-9006870
(
R-HSA-9020958
)
R-HSA-9006870
Reaction Name: IL21 receptor STAT phosphorylation
See in Reactome
R-HSA-9006873
(
R-HSA-9020958
)
R-HSA-9009700
(
R-HSA-8983432
)
R-HSA-9009700
Reaction Name: IL2RB and IL2RG are phosphorylated
See in Reactome
R-HSA-9025969
(
R-HSA-1266695
)
R-HSA-9025969
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
See in Reactome
R-HSA-912527
(
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-913374
(
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-913424
(
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-919404
(
R-HSA-9020558
)
R-HSA-919404
Reaction Name: Phosphorylated STAT5 is released
See in Reactome
R-HSA-9679028
(
R-HSA-1266695;
R-HSA-6785807;
R-HSA-8985947;
R-HSA-9020558
)
R-HSA-9701485
(
R-HSA-201556
)
R-HSA-9701488
(
R-HSA-201556
)
R-HSA-9701488
Reaction Name: Active ALK phosphorylates JAK3
See in Reactome
R-HSA-9701507
(
R-HSA-201556
)
|
MONDO:0010947 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0011996 |
ABL1 |
P00519 |
2.7.10.2
|
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-428890
R-HSA-428890
Reactome Name: Role of ABL in ROBO-SLIT signaling
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-525793
|
R-HSA-376176
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-168249
R-HSA-422475
R-HSA-195258
R-HSA-5693538
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
DNA Repair
Hemostasis
Signal Transduction
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376141
(
R-HSA-428890
)
R-HSA-376141
Reaction Name: Interaction of ABL with ROBO1:SLIT2
See in Reactome
R-HSA-428883
(
R-HSA-428890
)
R-HSA-428885
(
R-HSA-428890
)
R-HSA-428888
(
R-HSA-428890
)
R-HSA-428888
Reaction Name: Phosphorylation of ROBO1 by ABL kinase
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686587
(
R-HSA-5685938
)
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8956639
(
R-HSA-8939236
)
R-HSA-8956659
(
R-HSA-8939236
)
R-HSA-8985227
(
R-HSA-8940973
)
R-HSA-8985227
Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
See in Reactome
|
MONDO:0012161 |
ZAP70 |
P43403 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-9013407
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
|
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-202403
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
|
MONDO:0012682 |
TYK2 |
P29597 |
2.7.10.2
|
R-HSA-1059683
R-HSA-449836
R-HSA-8984722
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-9674555
R-HSA-112411
R-HSA-6783783
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-9020956
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-9020933
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5684996
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-448661
(
R-HSA-449836;
R-HSA-8854691
)
R-HSA-448661
Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-449811
(
R-HSA-6783783
)
R-HSA-449811
Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-6784006
(
R-HSA-6783783
)
R-HSA-6784006
Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-6784319
(
R-HSA-6783783
)
R-HSA-6784319
Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2
See in Reactome
R-HSA-6784323
(
R-HSA-6783783
)
R-HSA-6784323
Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
See in Reactome
R-HSA-6784324
(
R-HSA-6783783
)
R-HSA-6784324
Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
See in Reactome
R-HSA-6784791
(
R-HSA-6783783
)
R-HSA-6784791
Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-6785762
(
R-HSA-6785807
)
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-6786118
(
R-HSA-6785807
)
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-8854645
(
R-HSA-8854691
)
R-HSA-8854645
Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-8950057
(
R-HSA-9020591
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-8986480
(
R-HSA-8854691
)
R-HSA-8986480
Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-8986985
(
R-HSA-8854691
)
R-HSA-8986985
Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
See in Reactome
R-HSA-8986994
(
R-HSA-8854691
)
R-HSA-8986994
Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
See in Reactome
R-HSA-8986995
(
R-HSA-8854691
)
R-HSA-8986995
Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987033
(
R-HSA-8854691
)
R-HSA-8987033
Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
See in Reactome
R-HSA-8987040
(
R-HSA-8854691
)
R-HSA-8987040
Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
See in Reactome
R-HSA-8987042
(
R-HSA-8854691
)
R-HSA-8987042
Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987080
(
R-HSA-8854691
)
R-HSA-8987080
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
See in Reactome
R-HSA-8987105
(
R-HSA-8854691
)
R-HSA-8987105
Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987202
(
R-HSA-8854691
)
R-HSA-8987202
Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-8987223
(
R-HSA-8854691
)
R-HSA-8987230
(
R-HSA-8854691
)
R-HSA-8987230
Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-8987255
(
R-HSA-8854691
)
R-HSA-8987255
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
See in Reactome
R-HSA-8987266
(
R-HSA-8854691
)
R-HSA-8987266
Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
See in Reactome
R-HSA-909718
(
R-HSA-909733
)
R-HSA-909719
(
R-HSA-909733
)
R-HSA-909719
Reaction Name: Recruitment of STAT2 to p-IFNAR1
See in Reactome
R-HSA-909722
(
R-HSA-909733
)
R-HSA-909722
Reaction Name: Release of p-STAT2:p-STAT1 dimer
See in Reactome
R-HSA-909724
(
R-HSA-909733
)
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909729
(
R-HSA-909733
)
R-HSA-909730
(
R-HSA-909733
)
R-HSA-909730
Reaction Name: Phosphorylation of INFAR1 by TYK2
See in Reactome
R-HSA-909732
(
R-HSA-909733
)
R-HSA-912680
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-912680
Reaction Name: Inhibition of JAK kinase activity by SOCS1/3
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9678737
(
R-HSA-909733
)
R-HSA-9678737
Reaction Name: IFNAR1:TYK2 binds TYK2 inhibitors
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
R-HSA-997311
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997311
Reaction Name: Dephosphorylation of TYK2 by PTP1B
See in Reactome
R-HSA-997314
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997314
Reaction Name: Dephosphorylation of JAK1 by SHP1
See in Reactome
|
MONDO:0013081 |
ITK |
Q08881 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
|
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1280218
R-HSA-202403
|
Immune System
|
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202375
(
R-HSA-202433
)
R-HSA-2730833
(
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730847
(
R-HSA-2871809
)
R-HSA-2730858
(
R-HSA-2871809
)
R-HSA-2730858
Reaction Name: Autophosphorylation of BTK/ITK
See in Reactome
R-HSA-2730885
(
R-HSA-2871809
)
R-HSA-2730885
Reaction Name: Recruitment of TEC kinases to p-SLP-76
See in Reactome
R-HSA-2730888
(
R-HSA-2871809
)
|
MONDO:0013242 |
BLK |
P51451 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-8939245
R-HSA-8939245
Reactome Name: RUNX1 regulates transcription of genes involved in BCR signaling
See in Reactome
|
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
R-HSA-73857
|
Gene expression (Transcription)
Immune System
|
R-HSA-8938987
(
R-HSA-8939245
)
R-HSA-8938987
Reaction Name: BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5
See in Reactome
R-HSA-983709
(
R-HSA-983695
)
R-HSA-983709
Reaction Name: LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
See in Reactome
|
MONDO:0013743 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508;
R-HSA-416476
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0013794 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0014253 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508;
R-HSA-416476
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0014334 |
LCK |
P06239 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-389948
R-HSA-1433559
R-HSA-202424
R-HSA-9020558
R-HSA-1257604
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-1433557
R-HSA-389513
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-2424491
R-HSA-389356
R-HSA-210990
R-HSA-389359
R-HSA-9013407
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-109582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-9012999
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-162582
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-202403
|
Hemostasis
Immune System
Signal Transduction
|
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433506
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1433542
(
R-HSA-1433557
)
R-HSA-1433542
Reaction Name: Phosphorylation and activation of VAV1
See in Reactome
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-1472121
(
R-HSA-1433557
)
R-HSA-1472121
Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-202165
(
R-HSA-202427
)
R-HSA-202165
Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes
See in Reactome
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202233
(
R-HSA-202427
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202291
(
R-HSA-202427
)
R-HSA-202307
(
R-HSA-202424
)
R-HSA-202307
Reaction Name: Change of PKC theta conformation
See in Reactome
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-205205
(
R-HSA-1433557
)
R-HSA-205205
Reaction Name: Interaction of Src family kinases with p-KIT
See in Reactome
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-205244
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205319
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-210291
(
R-HSA-210990
)
R-HSA-210291
Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395439
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-388814
(
R-HSA-389356;
R-HSA-389359
)
R-HSA-388829
(
R-HSA-389513
)
R-HSA-388831
(
R-HSA-389356
)
R-HSA-388832
(
R-HSA-389356;
R-HSA-389357
)
R-HSA-388833
(
R-HSA-389513
)
R-HSA-389158
(
R-HSA-389356;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-389348
(
R-HSA-389356;
R-HSA-389359
)
R-HSA-389350
(
R-HSA-389356;
R-HSA-389359
)
R-HSA-389352
(
R-HSA-389356;
R-HSA-389359
)
R-HSA-389354
(
R-HSA-389356;
R-HSA-389359
)
R-HSA-389381
(
R-HSA-389356
)
R-HSA-389758
(
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389762
(
R-HSA-389948
)
R-HSA-434836
(
R-HSA-114604
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9706312
(
R-HSA-9706374
)
|
MONDO:0014837 |
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0014861 |
ZAP70 |
P43403 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-9013407
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
|
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-202403
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
|
MONDO:0015517 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509;
R-HSA-418594
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508;
R-HSA-416476
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0018314 |
TNK2 |
Q07912 |
2.7.10.2
2.7.11.1
|
|
|
|
|
MONDO:0018874 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0018967 |
BTK |
Q06187 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-1236974
R-HSA-416476
R-HSA-2424491
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-8964315
R-HSA-8964315
Reactome Name: G beta:gamma signalling through BTK
See in Reactome
|
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-194315
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-168256
R-HSA-168898
R-HSA-195258
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-2172127
R-HSA-168249
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-388396
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-166072
(
R-HSA-166058
)
R-HSA-166072
Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4
See in Reactome
R-HSA-166082
(
R-HSA-166058
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-2197698
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2201322
(
R-HSA-166058
)
R-HSA-2201322
Reaction Name: TIRAP is phosphorylated by BTK
See in Reactome
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2424481
(
R-HSA-2424491
)
R-HSA-2424481
Reaction Name: Recruitment of VAV and BTK to p-SLP-76
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424485
(
R-HSA-2424491
)
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2559414
(
R-HSA-166058
)
R-HSA-2559414
Reaction Name: Activated TLR2/4:TIRAP interacts with BTK
See in Reactome
R-HSA-2730833
(
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730847
(
R-HSA-2871809
)
R-HSA-2730858
(
R-HSA-2871809
)
R-HSA-2730858
Reaction Name: Autophosphorylation of BTK/ITK
See in Reactome
R-HSA-2730885
(
R-HSA-2871809
)
R-HSA-2730885
Reaction Name: Recruitment of TEC kinases to p-SLP-76
See in Reactome
R-HSA-2730888
(
R-HSA-2871809
)
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-8964241
(
R-HSA-8964315
)
R-HSA-8964241
Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane
See in Reactome
R-HSA-8964246
(
R-HSA-416482
)
R-HSA-8964246
Reaction Name: BTK in G alpha (12)-BTK complex is activated
See in Reactome
R-HSA-8964271
(
R-HSA-8964315
)
R-HSA-8964271
Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated
See in Reactome
R-HSA-8964274
(
R-HSA-416482
)
R-HSA-8964280
(
R-HSA-416476
)
R-HSA-8964284
(
R-HSA-416476
)
R-HSA-8964284
Reaction Name: BTK in active Gq-BTK complex is activated
See in Reactome
R-HSA-8964317
(
R-HSA-8964315
)
R-HSA-8964317
Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
See in Reactome
R-HSA-8964333
(
R-HSA-416482
)
R-HSA-8964333
Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
See in Reactome
R-HSA-8964340
(
R-HSA-416476
)
R-HSA-8964340
Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq
See in Reactome
R-HSA-937022
(
R-HSA-166058
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-937079
(
R-HSA-166058
)
R-HSA-937079
Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
See in Reactome
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
|
MONDO:0020526 |
JAK1 |
P23458 |
2.7.10.2
|
R-HSA-8984722
R-HSA-1169408
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-9020956
R-HSA-9020958
R-HSA-5673001
R-HSA-1266695
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-8985947
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-8983432
R-HSA-6783783
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-449836
R-HSA-9674555
R-HSA-112411
R-HSA-877312
R-HSA-9020558
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-913531
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-5684996
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-9677585
(
R-HSA-9674555
)
R-HSA-9677585
Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1
See in Reactome
R-HSA-909720
(
R-HSA-909733
)
R-HSA-8987266
(
R-HSA-8854691
)
R-HSA-8987266
Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
See in Reactome
R-HSA-448708
(
R-HSA-8854691
)
R-HSA-448708
Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-8983335
(
R-HSA-8983432
)
R-HSA-8983335
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
See in Reactome
R-HSA-8985988
(
R-HSA-8985947
)
R-HSA-8985988
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-6784319
(
R-HSA-6783783
)
R-HSA-6784319
Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2
See in Reactome
R-HSA-8987105
(
R-HSA-8854691
)
R-HSA-8987105
Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-451900
(
R-HSA-9020558
)
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-8987015
(
R-HSA-8854691
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-452091
(
R-HSA-9020558
)
R-HSA-452091
Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment
See in Reactome
R-HSA-8854645
(
R-HSA-8854691
)
R-HSA-8854645
Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-9006873
(
R-HSA-9020958
)
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-9025969
(
R-HSA-1266695
)
R-HSA-9025969
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
See in Reactome
R-HSA-9005980
(
R-HSA-9020958
)
R-HSA-912680
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-912680
Reaction Name: Inhibition of JAK kinase activity by SOCS1/3
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-448661
(
R-HSA-449836;
R-HSA-8854691
)
R-HSA-448661
Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-449811
(
R-HSA-6783783
)
R-HSA-449811
Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-8987270
(
R-HSA-8854691
)
R-HSA-8987270
Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9674558
(
R-HSA-9674555
)
R-HSA-9674558
Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
See in Reactome
R-HSA-8982165
(
R-HSA-8854691
)
R-HSA-8982165
Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-9678935
(
R-HSA-909733
)
R-HSA-9678935
Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8983374
(
R-HSA-8983432
)
R-HSA-8983374
Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
See in Reactome
R-HSA-8987080
(
R-HSA-8854691
)
R-HSA-8987080
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
See in Reactome
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8987039
(
R-HSA-8854691
)
R-HSA-508247
(
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-8986480
(
R-HSA-8854691
)
R-HSA-8986480
Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-8985929
(
R-HSA-8985947
)
R-HSA-8985929
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8983425
(
R-HSA-8983432
)
R-HSA-8983425
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
See in Reactome
R-HSA-6784791
(
R-HSA-6783783
)
R-HSA-6784791
Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8987040
(
R-HSA-8854691
)
R-HSA-8987040
Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
See in Reactome
R-HSA-909718
(
R-HSA-909733
)
R-HSA-449803
(
R-HSA-6783783
)
R-HSA-8987161
(
R-HSA-8854691
)
R-HSA-8987161
Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3
See in Reactome
R-HSA-8987129
(
R-HSA-8854691
)
R-HSA-8987129
Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-6784006
(
R-HSA-6783783
)
R-HSA-6784006
Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
See in Reactome
R-HSA-452108
(
R-HSA-9020558
)
R-HSA-452108
Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-909729
(
R-HSA-909733
)
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-8983371
(
R-HSA-8983432
)
R-HSA-8983371
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
R-HSA-997314
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997314
Reaction Name: Dephosphorylation of JAK1 by SHP1
See in Reactome
R-HSA-873918
(
R-HSA-877300
)
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-6784324
(
R-HSA-6783783
)
R-HSA-6784324
Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
See in Reactome
R-HSA-450063
(
R-HSA-9020558
)
R-HSA-450063
Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
See in Reactome
R-HSA-8982162
(
R-HSA-8854691
)
R-HSA-8982162
Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
See in Reactome
R-HSA-8963734
(
R-HSA-8985947
)
R-HSA-8963734
Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-8987120
(
R-HSA-8854691
)
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-452097
(
R-HSA-9020558
)
R-HSA-452097
Reaction Name: Recruited STAT5 is phosphorylated
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8983298
(
R-HSA-8983432
)
R-HSA-8983298
Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-448480
(
R-HSA-8854691
)
R-HSA-448480
Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-909730
(
R-HSA-909733
)
R-HSA-909730
Reaction Name: Phosphorylation of INFAR1 by TYK2
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-919404
(
R-HSA-9020558
)
R-HSA-919404
Reaction Name: Phosphorylated STAT5 is released
See in Reactome
R-HSA-8986972
(
R-HSA-8854691
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8983424
(
R-HSA-8983432
)
R-HSA-8983424
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-9009700
(
R-HSA-8983432
)
R-HSA-9009700
Reaction Name: IL2RB and IL2RG are phosphorylated
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-8983394
(
R-HSA-8983432
)
R-HSA-8983394
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
See in Reactome
R-HSA-9677579
(
R-HSA-9674555
)
R-HSA-9677579
Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
See in Reactome
R-HSA-8986994
(
R-HSA-8854691
)
R-HSA-8986994
Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-449958
(
R-HSA-1266695
)
R-HSA-8950716
(
R-HSA-9020956
)
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-1264832
(
R-HSA-1266695
)
R-HSA-8987202
(
R-HSA-8854691
)
R-HSA-8987202
Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-909724
(
R-HSA-909733
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-8987097
(
R-HSA-8854691
)
R-HSA-8987097
Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3
See in Reactome
R-HSA-997311
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997311
Reaction Name: Dephosphorylation of TYK2 by PTP1B
See in Reactome
R-HSA-8987042
(
R-HSA-8854691
)
R-HSA-8987042
Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-448744
(
R-HSA-8854691
)
R-HSA-8986446
(
R-HSA-8854691
)
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-8985900
(
R-HSA-8985947
)
R-HSA-8985900
Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
See in Reactome
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-8987012
(
R-HSA-8854691
)
R-HSA-8987012
Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-909719
(
R-HSA-909733
)
R-HSA-909719
Reaction Name: Recruitment of STAT2 to p-IFNAR1
See in Reactome
R-HSA-912527
(
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-9006844
(
R-HSA-9020958
)
R-HSA-9006844
Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-909732
(
R-HSA-909733
)
R-HSA-9009227
(
R-HSA-8854691
)
R-HSA-9009227
Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-6785165
(
R-HSA-1266695
)
R-HSA-6785165
Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
See in Reactome
R-HSA-913424
(
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-1295540
(
R-HSA-1266695
)
R-HSA-1295540
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-8983063
(
R-HSA-1266695
)
R-HSA-8983063
Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
See in Reactome
R-HSA-8982163
(
R-HSA-8854691
)
R-HSA-8982163
Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-450027
(
R-HSA-9020558
)
R-HSA-450027
Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
See in Reactome
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-8987255
(
R-HSA-8854691
)
R-HSA-8987255
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
See in Reactome
R-HSA-1295519
(
R-HSA-1266695
)
R-HSA-1295519
Reaction Name: IL7R is phosphorylated on Y499
See in Reactome
R-HSA-448728
(
R-HSA-8854691
)
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8987084
(
R-HSA-8854691
)
R-HSA-8987084
Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-8983003
(
R-HSA-1266695
)
R-HSA-8983003
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
See in Reactome
R-HSA-449978
(
R-HSA-1266695
)
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9011748
(
R-HSA-8985947
)
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-6784323
(
R-HSA-6783783
)
R-HSA-6784323
Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
See in Reactome
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-453104
(
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-449115
(
R-HSA-8983432
)
R-HSA-449115
Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987063
(
R-HSA-8854691
)
R-HSA-8987063
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-8987043
(
R-HSA-8854691
)
R-HSA-8983384
(
R-HSA-8983432
)
R-HSA-8983384
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
See in Reactome
R-HSA-913374
(
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-9006850
(
R-HSA-9020958
)
R-HSA-9006850
Reaction Name: IL21 receptor JAK phosphorylation
See in Reactome
R-HSA-8987150
(
R-HSA-8854691
)
R-HSA-8987150
Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-8983300
(
R-HSA-8983432
)
R-HSA-8983300
Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8987096
(
R-HSA-8854691
)
R-HSA-8987096
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-8986995
(
R-HSA-8854691
)
R-HSA-8986995
Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
See in Reactome
R-HSA-8986985
(
R-HSA-8854691
)
R-HSA-8986985
Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-452122
(
R-HSA-9020558
)
R-HSA-452122
Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
See in Reactome
R-HSA-909722
(
R-HSA-909733
)
R-HSA-909722
Reaction Name: Release of p-STAT2:p-STAT1 dimer
See in Reactome
R-HSA-8987033
(
R-HSA-8854691
)
R-HSA-8987033
Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
See in Reactome
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-8983309
(
R-HSA-8983432
)
R-HSA-8983309
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
See in Reactome
R-HSA-448660
(
R-HSA-6788467
)
R-HSA-448660
Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-8985973
(
R-HSA-8985947
)
R-HSA-8985973
Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
See in Reactome
R-HSA-451942
(
R-HSA-9020558
)
R-HSA-451942
Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1
See in Reactome
R-HSA-9006870
(
R-HSA-9020958
)
R-HSA-9006870
Reaction Name: IL21 receptor STAT phosphorylation
See in Reactome
R-HSA-8985914
(
R-HSA-8985947
)
R-HSA-8985914
Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-8983299
(
R-HSA-8983432
)
R-HSA-8983299
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-8983378
(
R-HSA-8983432
)
R-HSA-8983378
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
See in Reactome
R-HSA-453111
(
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-8987230
(
R-HSA-8854691
)
R-HSA-8987230
Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1295516
(
R-HSA-1266695
)
R-HSA-1295516
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-9674546
(
R-HSA-9674555
)
R-HSA-9674546
Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
See in Reactome
|
MONDO:0020729 |
BTK |
Q06187 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-1236974
R-HSA-416476
R-HSA-2424491
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-8964315
R-HSA-8964315
Reactome Name: G beta:gamma signalling through BTK
See in Reactome
|
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-372790
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-194315
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-168256
R-HSA-168898
R-HSA-195258
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-2172127
R-HSA-168249
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-388396
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-166072
(
R-HSA-166058
)
R-HSA-166072
Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4
See in Reactome
R-HSA-166082
(
R-HSA-166058
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-2197698
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2201322
(
R-HSA-166058
)
R-HSA-2201322
Reaction Name: TIRAP is phosphorylated by BTK
See in Reactome
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2424481
(
R-HSA-2424491
)
R-HSA-2424481
Reaction Name: Recruitment of VAV and BTK to p-SLP-76
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424485
(
R-HSA-2424491
)
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2559414
(
R-HSA-166058
)
R-HSA-2559414
Reaction Name: Activated TLR2/4:TIRAP interacts with BTK
See in Reactome
R-HSA-2730833
(
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730847
(
R-HSA-2871809
)
R-HSA-2730858
(
R-HSA-2871809
)
R-HSA-2730858
Reaction Name: Autophosphorylation of BTK/ITK
See in Reactome
R-HSA-2730885
(
R-HSA-2871809
)
R-HSA-2730885
Reaction Name: Recruitment of TEC kinases to p-SLP-76
See in Reactome
R-HSA-2730888
(
R-HSA-2871809
)
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-8964241
(
R-HSA-8964315
)
R-HSA-8964241
Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane
See in Reactome
R-HSA-8964246
(
R-HSA-416482
)
R-HSA-8964246
Reaction Name: BTK in G alpha (12)-BTK complex is activated
See in Reactome
R-HSA-8964271
(
R-HSA-8964315
)
R-HSA-8964271
Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated
See in Reactome
R-HSA-8964274
(
R-HSA-416482
)
R-HSA-8964280
(
R-HSA-416476
)
R-HSA-8964284
(
R-HSA-416476
)
R-HSA-8964284
Reaction Name: BTK in active Gq-BTK complex is activated
See in Reactome
R-HSA-8964317
(
R-HSA-8964315
)
R-HSA-8964317
Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
See in Reactome
R-HSA-8964333
(
R-HSA-416482
)
R-HSA-8964333
Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
See in Reactome
R-HSA-8964340
(
R-HSA-416476
)
R-HSA-8964340
Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq
See in Reactome
R-HSA-937022
(
R-HSA-166058
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-937079
(
R-HSA-166058
)
R-HSA-937079
Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
See in Reactome
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
|
MONDO:0020837 |
WEE2 |
P0C1S8 |
2.7.10.2
|
|
|
|
|
MONDO:0021094 |
MONDO:0021094
Disease Name: immunodeficiency disease
All associated enzymes in DAR:
SYK
. The disease is also associated to other non-enzyme proteins (not in DAR).
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0023644 |
ABL1 |
P00519 |
2.7.10.2
|
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-428890
R-HSA-428890
Reactome Name: Role of ABL in ROBO-SLIT signaling
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-525793
|
R-HSA-376176
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-168249
R-HSA-422475
R-HSA-195258
R-HSA-5693538
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
DNA Repair
Hemostasis
Signal Transduction
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376141
(
R-HSA-428890
)
R-HSA-376141
Reaction Name: Interaction of ABL with ROBO1:SLIT2
See in Reactome
R-HSA-428883
(
R-HSA-428890
)
R-HSA-428885
(
R-HSA-428890
)
R-HSA-428888
(
R-HSA-428890
)
R-HSA-428888
Reaction Name: Phosphorylation of ROBO1 by ABL kinase
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686587
(
R-HSA-5685938
)
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8956639
(
R-HSA-8939236
)
R-HSA-8956659
(
R-HSA-8939236
)
R-HSA-8985227
(
R-HSA-8940973
)
R-HSA-8985227
Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
See in Reactome
|
MONDO:0030035 |
EIF2AK2 |
P19525 |
2.7.10.2
2.7.11.1
|
R-HSA-1169408
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
|
Immune System
|
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
|
MONDO:0032935 |
PKDCC |
Q504Y2 |
2.7.10.2
|
|
|
|
|
MONDO:0033558 |
JAK1 |
P23458 |
2.7.10.2
|
R-HSA-8984722
R-HSA-1169408
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-9020956
R-HSA-9020958
R-HSA-5673001
R-HSA-1266695
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-8985947
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-8983432
R-HSA-6783783
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-449836
R-HSA-9674555
R-HSA-112411
R-HSA-877312
R-HSA-9020558
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-913531
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-5684996
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-9677585
(
R-HSA-9674555
)
R-HSA-9677585
Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1
See in Reactome
R-HSA-909720
(
R-HSA-909733
)
R-HSA-8987266
(
R-HSA-8854691
)
R-HSA-8987266
Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
See in Reactome
R-HSA-448708
(
R-HSA-8854691
)
R-HSA-448708
Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-8983335
(
R-HSA-8983432
)
R-HSA-8983335
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
See in Reactome
R-HSA-8985988
(
R-HSA-8985947
)
R-HSA-8985988
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-6784319
(
R-HSA-6783783
)
R-HSA-6784319
Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2
See in Reactome
R-HSA-8987105
(
R-HSA-8854691
)
R-HSA-8987105
Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-451900
(
R-HSA-9020558
)
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-8987015
(
R-HSA-8854691
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-452091
(
R-HSA-9020558
)
R-HSA-452091
Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment
See in Reactome
R-HSA-8854645
(
R-HSA-8854691
)
R-HSA-8854645
Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-9006873
(
R-HSA-9020958
)
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-9025969
(
R-HSA-1266695
)
R-HSA-9025969
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
See in Reactome
R-HSA-9005980
(
R-HSA-9020958
)
R-HSA-912680
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-912680
Reaction Name: Inhibition of JAK kinase activity by SOCS1/3
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-448661
(
R-HSA-449836;
R-HSA-8854691
)
R-HSA-448661
Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
See in Reactome
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-449811
(
R-HSA-6783783
)
R-HSA-449811
Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-8987270
(
R-HSA-8854691
)
R-HSA-8987270
Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9674558
(
R-HSA-9674555
)
R-HSA-9674558
Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
See in Reactome
R-HSA-8982165
(
R-HSA-8854691
)
R-HSA-8982165
Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-9678935
(
R-HSA-909733
)
R-HSA-9678935
Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8983374
(
R-HSA-8983432
)
R-HSA-8983374
Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
See in Reactome
R-HSA-8987080
(
R-HSA-8854691
)
R-HSA-8987080
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
See in Reactome
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8987039
(
R-HSA-8854691
)
R-HSA-508247
(
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-8986480
(
R-HSA-8854691
)
R-HSA-8986480
Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-8985929
(
R-HSA-8985947
)
R-HSA-8985929
Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8983425
(
R-HSA-8983432
)
R-HSA-8983425
Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
See in Reactome
R-HSA-6784791
(
R-HSA-6783783
)
R-HSA-6784791
Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8987040
(
R-HSA-8854691
)
R-HSA-8987040
Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
See in Reactome
R-HSA-909718
(
R-HSA-909733
)
R-HSA-449803
(
R-HSA-6783783
)
R-HSA-8987161
(
R-HSA-8854691
)
R-HSA-8987161
Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3
See in Reactome
R-HSA-8987129
(
R-HSA-8854691
)
R-HSA-8987129
Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-6784006
(
R-HSA-6783783
)
R-HSA-6784006
Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
See in Reactome
R-HSA-452108
(
R-HSA-9020558
)
R-HSA-452108
Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-909729
(
R-HSA-909733
)
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-8983371
(
R-HSA-8983432
)
R-HSA-8983371
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
R-HSA-997314
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997314
Reaction Name: Dephosphorylation of JAK1 by SHP1
See in Reactome
R-HSA-873918
(
R-HSA-877300
)
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-6784324
(
R-HSA-6783783
)
R-HSA-6784324
Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
See in Reactome
R-HSA-450063
(
R-HSA-9020558
)
R-HSA-450063
Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
See in Reactome
R-HSA-8982162
(
R-HSA-8854691
)
R-HSA-8982162
Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
See in Reactome
R-HSA-8963734
(
R-HSA-8985947
)
R-HSA-8963734
Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-8987120
(
R-HSA-8854691
)
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-452097
(
R-HSA-9020558
)
R-HSA-452097
Reaction Name: Recruited STAT5 is phosphorylated
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8983298
(
R-HSA-8983432
)
R-HSA-8983298
Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-448480
(
R-HSA-8854691
)
R-HSA-448480
Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-909730
(
R-HSA-909733
)
R-HSA-909730
Reaction Name: Phosphorylation of INFAR1 by TYK2
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-919404
(
R-HSA-9020558
)
R-HSA-919404
Reaction Name: Phosphorylated STAT5 is released
See in Reactome
R-HSA-8986972
(
R-HSA-8854691
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8983424
(
R-HSA-8983432
)
R-HSA-8983424
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-9009700
(
R-HSA-8983432
)
R-HSA-9009700
Reaction Name: IL2RB and IL2RG are phosphorylated
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-8983394
(
R-HSA-8983432
)
R-HSA-8983394
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
See in Reactome
R-HSA-9677579
(
R-HSA-9674555
)
R-HSA-9677579
Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
See in Reactome
R-HSA-8986994
(
R-HSA-8854691
)
R-HSA-8986994
Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-449958
(
R-HSA-1266695
)
R-HSA-8950716
(
R-HSA-9020956
)
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-1264832
(
R-HSA-1266695
)
R-HSA-8987202
(
R-HSA-8854691
)
R-HSA-8987202
Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-909724
(
R-HSA-909733
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-8987097
(
R-HSA-8854691
)
R-HSA-8987097
Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3
See in Reactome
R-HSA-997311
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997311
Reaction Name: Dephosphorylation of TYK2 by PTP1B
See in Reactome
R-HSA-8987042
(
R-HSA-8854691
)
R-HSA-8987042
Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
See in Reactome
R-HSA-448744
(
R-HSA-8854691
)
R-HSA-8986446
(
R-HSA-8854691
)
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-8985900
(
R-HSA-8985947
)
R-HSA-8985900
Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
See in Reactome
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-8987012
(
R-HSA-8854691
)
R-HSA-8987012
Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-909719
(
R-HSA-909733
)
R-HSA-909719
Reaction Name: Recruitment of STAT2 to p-IFNAR1
See in Reactome
R-HSA-912527
(
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-9006844
(
R-HSA-9020958
)
R-HSA-9006844
Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-909732
(
R-HSA-909733
)
R-HSA-9009227
(
R-HSA-8854691
)
R-HSA-9009227
Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB
See in Reactome
R-HSA-6785165
(
R-HSA-1266695
)
R-HSA-6785165
Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
See in Reactome
R-HSA-913424
(
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-1295540
(
R-HSA-1266695
)
R-HSA-1295540
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-8983063
(
R-HSA-1266695
)
R-HSA-8983063
Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
See in Reactome
R-HSA-8982163
(
R-HSA-8854691
)
R-HSA-8982163
Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-450027
(
R-HSA-9020558
)
R-HSA-450027
Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
See in Reactome
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-8987255
(
R-HSA-8854691
)
R-HSA-8987255
Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
See in Reactome
R-HSA-1295519
(
R-HSA-1266695
)
R-HSA-1295519
Reaction Name: IL7R is phosphorylated on Y499
See in Reactome
R-HSA-448728
(
R-HSA-8854691
)
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8987084
(
R-HSA-8854691
)
R-HSA-8987084
Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
See in Reactome
R-HSA-8983003
(
R-HSA-1266695
)
R-HSA-8983003
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
See in Reactome
R-HSA-449978
(
R-HSA-1266695
)
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9011748
(
R-HSA-8985947
)
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-6784323
(
R-HSA-6783783
)
R-HSA-6784323
Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3
See in Reactome
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-453104
(
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-449115
(
R-HSA-8983432
)
R-HSA-449115
Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
See in Reactome
R-HSA-8987063
(
R-HSA-8854691
)
R-HSA-8987063
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
See in Reactome
R-HSA-8987043
(
R-HSA-8854691
)
R-HSA-8983384
(
R-HSA-8983432
)
R-HSA-8983384
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
See in Reactome
R-HSA-913374
(
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-9006850
(
R-HSA-9020958
)
R-HSA-9006850
Reaction Name: IL21 receptor JAK phosphorylation
See in Reactome
R-HSA-8987150
(
R-HSA-8854691
)
R-HSA-8987150
Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-8983300
(
R-HSA-8983432
)
R-HSA-8983300
Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8987096
(
R-HSA-8854691
)
R-HSA-8987096
Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-8986995
(
R-HSA-8854691
)
R-HSA-8986995
Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
See in Reactome
R-HSA-8986985
(
R-HSA-8854691
)
R-HSA-8986985
Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-452122
(
R-HSA-9020558
)
R-HSA-452122
Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
See in Reactome
R-HSA-909722
(
R-HSA-909733
)
R-HSA-909722
Reaction Name: Release of p-STAT2:p-STAT1 dimer
See in Reactome
R-HSA-8987033
(
R-HSA-8854691
)
R-HSA-8987033
Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
See in Reactome
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-8983309
(
R-HSA-8983432
)
R-HSA-8983309
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
See in Reactome
R-HSA-448660
(
R-HSA-6788467
)
R-HSA-448660
Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-8985973
(
R-HSA-8985947
)
R-HSA-8985973
Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
See in Reactome
R-HSA-451942
(
R-HSA-9020558
)
R-HSA-451942
Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1
See in Reactome
R-HSA-9006870
(
R-HSA-9020958
)
R-HSA-9006870
Reaction Name: IL21 receptor STAT phosphorylation
See in Reactome
R-HSA-8985914
(
R-HSA-8985947
)
R-HSA-8985914
Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-8983299
(
R-HSA-8983432
)
R-HSA-8983299
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-8983378
(
R-HSA-8983432
)
R-HSA-8983378
Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
See in Reactome
R-HSA-453111
(
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-8987230
(
R-HSA-8854691
)
R-HSA-8987230
Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1295516
(
R-HSA-1266695
)
R-HSA-1295516
Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-9674546
(
R-HSA-9674555
)
R-HSA-9674546
Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
See in Reactome
|
MONDO:0044626 |
WEE2 |
P0C1S8 |
2.7.10.2
|
|
|
|
|
MONDO:0044903 |
MONDO:0044903
Disease Name: myelofibrosis
All associated enzymes in DAR:
SRC
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0060532 |
ABL1 |
P00519 |
2.7.10.2
|
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-428890
R-HSA-428890
Reactome Name: Role of ABL in ROBO-SLIT signaling
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-525793
|
R-HSA-376176
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-168249
R-HSA-422475
R-HSA-195258
R-HSA-5693538
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
DNA Repair
Hemostasis
Signal Transduction
|
R-HSA-1013833
(
R-HSA-983231
)
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376141
(
R-HSA-428890
)
R-HSA-376141
Reaction Name: Interaction of ABL with ROBO1:SLIT2
See in Reactome
R-HSA-428883
(
R-HSA-428890
)
R-HSA-428885
(
R-HSA-428890
)
R-HSA-428888
(
R-HSA-428890
)
R-HSA-428888
Reaction Name: Phosphorylation of ROBO1 by ABL kinase
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686587
(
R-HSA-5685938
)
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8956639
(
R-HSA-8939236
)
R-HSA-8956659
(
R-HSA-8939236
)
R-HSA-8985227
(
R-HSA-8940973
)
R-HSA-8985227
Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter
See in Reactome
|