DAR - Bologna Biocomputing Group

Search summary (EC number: 2.7.10.1)

Number of enzymes:	34
Number of disease:	161
Number of reactomes:	150
Number of reactions:	727

Search results (EC number: 2.7.10.1)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0019438	FLT3	P36888	2.7.10.1	R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Immune System Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6786789 ( R-HSA-9607240 ) R-HSA-6786789 Reaction Name: FLT3LG dimer binds FLT3 See in Reactome R-HSA-8854736 ( R-HSA-9607240 ) R-HSA-8854736 Reaction Name: FLT3LG dimer:FLT3 binds FLT3 See in Reactome R-HSA-9604738 ( R-HSA-9607240 ) R-HSA-9604738 Reaction Name: Active FLT3 dimer binds GRB2 See in Reactome R-HSA-9604767 ( R-HSA-9607240 ) R-HSA-9604767 Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9605259 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9605259 Reaction Name: Active FLT3 binds FYN See in Reactome R-HSA-9606622 ( R-HSA-9607240 ) R-HSA-9606622 Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated See in Reactome R-HSA-9606624 ( R-HSA-9607240 ) R-HSA-9606624 Reaction Name: Active FLT3:GRB2 binds GAB2 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9607224 ( R-HSA-9607240 ) R-HSA-9607224 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 See in Reactome R-HSA-9607301 ( R-HSA-9607240 ) R-HSA-9607301 Reaction Name: Active FLT3:GRB2 binds SOS1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9609274 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9609274 Reaction Name: Active FLT3 binds HCK See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9695828 ( R-HSA-9607240 ) R-HSA-9695828 Reaction Name: FLT3 binds type I TKI See in Reactome R-HSA-9695831 ( R-HSA-9607240 ) R-HSA-9695831 Reaction Name: FLT3 binds type II TKI See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9698408 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9698408 Reaction Name: PTPRJ dephosphorylates active FLT3 See in Reactome R-HSA-9699578 ( R-HSA-9607240 ) R-HSA-9699578 Reaction Name: Active FLT3 phosphorylates CDKN1B See in Reactome R-HSA-9706287 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706287 Reaction Name: Active FLT3 binds to ABL2 See in Reactome R-HSA-9706293 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706298 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706298 Reaction Name: Active FLT3 binds to CSK See in Reactome R-HSA-9706304 ( R-HSA-9607240 ) R-HSA-9706304 Reaction Name: Active FLT3 binds to GRAP2 See in Reactome R-HSA-9706308 ( R-HSA-9607240 ) R-HSA-9706308 Reaction Name: Active FLT3 binds to GRB10 See in Reactome R-HSA-9706312 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome R-HSA-9706315 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706315 Reaction Name: Active FLT3 binds to SH2B3 See in Reactome R-HSA-9706319 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706319 Reaction Name: Active FLT3 binds to SLA See in Reactome R-HSA-9706323 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706323 Reaction Name: Active FLT3 binds to SLA2 See in Reactome R-HSA-9706328 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706328 Reaction Name: Active FLT3 binds to SOCS2 See in Reactome R-HSA-9706330 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706330 Reaction Name: Active FLT3 binds to SOCS6 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9706340 ( R-HSA-9607240 ) R-HSA-9706340 Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1 See in Reactome R-HSA-9706344 ( R-HSA-9607240 ) R-HSA-9706344 Reaction Name: FLT3 phosphorylates GRB10 See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706350 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome R-HSA-9706364 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706364 Reaction Name: Internalization of ubiquitinated FLT3 See in Reactome
MONDO:0007540	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome
MONDO:0020667	FGFR2	P21802	2.7.10.1	R-HSA-5654221 R-HSA-5654221 Reactome Name: Phospholipase C-mediated cascade; FGFR2 See in Reactome R-HSA-190377 R-HSA-190377 Reactome Name: FGFR2b ligand binding and activation See in Reactome R-HSA-190375 R-HSA-190375 Reactome Name: FGFR2c ligand binding and activation See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-190241 R-HSA-190241 Reactome Name: FGFR2 ligand binding and activation See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190258 ( R-HSA-190375 ) R-HSA-190258 Reaction Name: FGFR2c binds to FGF See in Reactome R-HSA-190260 ( R-HSA-190377 ) R-HSA-190260 Reaction Name: FGFR2b binds to FGF See in Reactome R-HSA-190408 ( R-HSA-190377 ) R-HSA-190408 Reaction Name: Autocatalytic phosphorylation of FGFR2b See in Reactome R-HSA-190413 ( R-HSA-190375 ) R-HSA-190413 Reaction Name: Autocatalytic phosphorylation of FGFR2c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654147 ( R-HSA-5654221 ) R-HSA-5654147 Reaction Name: Activated FGFR2 phosphorylates PLCG1 See in Reactome R-HSA-5654157 ( R-HSA-5654221 ) R-HSA-5654157 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2 See in Reactome R-HSA-5654159 ( R-HSA-5654221 ) R-HSA-5654159 Reaction Name: Activated FGFR2 binds PLCG1 See in Reactome R-HSA-5654397 ( R-HSA-5654700 ) R-HSA-5654397 Reaction Name: Activated FGFR2 phosphorylates FRS2 See in Reactome R-HSA-5654399 ( R-HSA-5654700 ) R-HSA-5654399 Reaction Name: Activated FGFR2 binds FRS2 See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654404 ( R-HSA-5654699 ) R-HSA-5654404 Reaction Name: Activated FGFR2 binds SHC1 See in Reactome R-HSA-5654406 ( R-HSA-5654699 ) R-HSA-5654406 Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654407 ( R-HSA-5654699 ) R-HSA-5654407 Reaction Name: Activated FGFR2 phosphorylates SHC1 See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654603 ( R-HSA-5654700 ) R-HSA-5654603 Reaction Name: Activated FGFR2 binds FRS3 See in Reactome R-HSA-5654605 ( R-HSA-5654700 ) R-HSA-5654605 Reaction Name: Activated FGFR2 phosphorylates FRS3 See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654612 ( R-HSA-5654695 ) R-HSA-5654612 Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654615 ( R-HSA-5654700 ) R-HSA-5654615 Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1 See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007958	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0015196	EPHB4	P54760	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome	R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928580 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928580 Reaction Name: SFKs phosphorylate EFNBs See in Reactome R-HSA-3928583 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928583 Reaction Name: FYN phosphorylates NMDAR2B See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928588 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928588 Reaction Name: EPHBs binds PTK2 See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928592 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928594 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928594 Reaction Name: SFKs phosphorylate GIT1 See in Reactome R-HSA-3928595 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928595 Reaction Name: N-WASP binds ARP2/3 and G-actin See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928598 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928598 Reaction Name: Recruitment of p190RhoGEF to p-FAK See in Reactome R-HSA-3928600 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928600 Reaction Name: N-WASP binds ITSN1 See in Reactome R-HSA-3928601 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928601 Reaction Name: CDC42 and PIP2 bind WASL, activating it See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928610 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928610 Reaction Name: PTK2 autophosphorylates at Y397 See in Reactome R-HSA-3928612 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928614 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928614 Reaction Name: EFNB:GRB4 binds GIT1 See in Reactome R-HSA-3928615 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928615 Reaction Name: EFNBs bind SFKs See in Reactome R-HSA-3928617 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928617 Reaction Name: EPHB2 binds KALRN See in Reactome R-HSA-3928623 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928623 Reaction Name: EPHBs bind NMDARs See in Reactome R-HSA-3928624 ( R-HSA-2682334 ) R-HSA-3928624 Reaction Name: EPHBs bind EFNBs See in Reactome R-HSA-3928625 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928627 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928627 Reaction Name: EPHB phosphorylates TIAM1 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928631 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928631 Reaction Name: GIT1 binds bPIX See in Reactome R-HSA-3928632 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928632 Reaction Name: ITSN1 exchanges GTP for GDP on CDC42, activating it See in Reactome R-HSA-3928633 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928639 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928639 Reaction Name: p-EFNB binds GRB4 See in Reactome R-HSA-3928640 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928644 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928644 Reaction Name: EPHB binds ITSN1 See in Reactome R-HSA-3928645 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928645 Reaction Name: EPHB:NMDAR binds TIAM1 See in Reactome R-HSA-3928654 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928654 Reaction Name: Clathrin internalises EPH:EFN complexes See in Reactome R-HSA-3928656 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-3928657 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-4093329 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-4093329 Reaction Name: EFNBs bind SDCBP See in Reactome R-HSA-4093330 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093330 Reaction Name: EPHB binds p120-RasGAP See in Reactome R-HSA-4093331 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093332 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093332 Reaction Name: p-EPHB phosphorylates SDC2 See in Reactome R-HSA-4093336 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-4093339 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome
MONDO:0001187	FGFR3	P22607	2.7.10.1	R-HSA-190372 R-HSA-190372 Reactome Name: FGFR3c ligand binding and activation See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654227 R-HSA-5654227 Reactome Name: Phospholipase C-mediated cascade; FGFR3 See in Reactome R-HSA-190371 R-HSA-190371 Reactome Name: FGFR3b ligand binding and activation See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-190239 R-HSA-190239 Reactome Name: FGFR3 ligand binding and activation See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-2404192; R-HSA-2428928 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190261 ( R-HSA-190372 ) R-HSA-190261 Reaction Name: FGFR3c binds to FGF See in Reactome R-HSA-190263 ( R-HSA-190371 ) R-HSA-190263 Reaction Name: FGFR3b binds to FGF See in Reactome R-HSA-190385 ( R-HSA-190371 ) R-HSA-190385 Reaction Name: Autocatalytic phosphorylation of FGFR3b See in Reactome R-HSA-190388 ( R-HSA-190372 ) R-HSA-190388 Reaction Name: Autocatalytic phosphorylation of FGFR3c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654148 ( R-HSA-5654227 ) R-HSA-5654148 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3 See in Reactome R-HSA-5654222 ( R-HSA-5654227 ) R-HSA-5654222 Reaction Name: Activated FGFR3 phosphorylates PLCG1 See in Reactome R-HSA-5654224 ( R-HSA-5654227 ) R-HSA-5654224 Reaction Name: Activated FGFR3 binds PLCG1 See in Reactome R-HSA-5654408 ( R-HSA-5654706 ) R-HSA-5654408 Reaction Name: Activated FGFR3 phosphorylates FRS2 See in Reactome R-HSA-5654409 ( R-HSA-5654706 ) R-HSA-5654409 Reaction Name: Activated FGFR3 binds FRS2 See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654416 ( R-HSA-5654706 ) R-HSA-5654416 Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654623 ( R-HSA-5654706 ) R-HSA-5654623 Reaction Name: Activated FGFR3 binds FRS3 See in Reactome R-HSA-5654625 ( R-HSA-5654704 ) R-HSA-5654625 Reaction Name: Activated FGFR3 binds SHC1 See in Reactome R-HSA-5654628 ( R-HSA-5654706 ) R-HSA-5654628 Reaction Name: Activated FGFR3 phosphorylates FRS3 See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654634 ( R-HSA-5654704 ) R-HSA-5654634 Reaction Name: Activated FGFR3 phosphorylates SHC1 See in Reactome R-HSA-5654637 ( R-HSA-5654710 ) R-HSA-5654637 Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654646 ( R-HSA-5654704 ) R-HSA-5654646 Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0014998	TEK	Q02763	2.7.10.1	R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome	Hemostasis Signal Transduction	R-HSA-204773 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204773 Reaction Name: Interaction of Tie2 and Grb7 See in Reactome R-HSA-204779 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204779 Reaction Name: Interaction of Tie2 with Ang1 See in Reactome R-HSA-204798 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-204813 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204813 Reaction Name: Interaction of Tie2 and Grb14 See in Reactome R-HSA-204824 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204824 Reaction Name: Interaction of Tie2 and Ang4 See in Reactome R-HSA-204850 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204850 Reaction Name: Interaction of Tie2 and Dok-2 See in Reactome R-HSA-204861 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204861 Reaction Name: Interaction of Tie2 and Shc1 See in Reactome R-HSA-204863 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204863 Reaction Name: Interaction of Tie2 with Ang2 See in Reactome R-HSA-204871 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204871 Reaction Name: Interaction of Tie2 and Grb2 See in Reactome R-HSA-204873 ( R-HSA-202733; R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-210872 ( R-HSA-202733; R-HSA-210993 ) R-HSA-210872 Reaction Name: Trans-phosphorylation of Tie2 See in Reactome R-HSA-210881 ( R-HSA-202733; R-HSA-210993 ) R-HSA-210881 Reaction Name: Dimerization of Tie2/Ang1 complex See in Reactome R-HSA-210974 ( R-HSA-202733; R-HSA-210993 ) R-HSA-210974 Reaction Name: Interaction of SOS-1 to Tie2 bound Grb2 See in Reactome R-HSA-210977 ( R-HSA-202733; R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome
MONDO:0008542	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome
MONDO:0009227	PDGFRB	P09619	2.7.10.1	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-1524182 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524182 Reaction Name: Activated PLC gamma dissociates from the PDGF receptor See in Reactome R-HSA-1524186 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524186 Reaction Name: Phosphorylation of PLCgamma by PDGFR See in Reactome R-HSA-186765 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186765 Reaction Name: PLC-gamma binds to the active receptor See in Reactome R-HSA-186773 ( R-HSA-186797 ) R-HSA-186773 Reaction Name: PDGF dimer binds two receptors simultaneously See in Reactome R-HSA-186778 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-186780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186786 ( R-HSA-186797 ) R-HSA-186786 Reaction Name: Autophosphorylation of PDGF beta receptors See in Reactome R-HSA-186798 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186798 Reaction Name: GAP binds to PDGF-beta receptors only See in Reactome R-HSA-186800 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-186819 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-186826 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186826 Reaction Name: GRB2:SOS1 complex binds to the active receptor See in Reactome R-HSA-186834 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-380780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-380782 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380782 Reaction Name: STAT binds to the active receptor See in Reactome R-HSA-382052 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382052 Reaction Name: p130Cas and C3G bind PDGFR bound Crk See in Reactome R-HSA-382055 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382055 Reaction Name: Grb7 binds to the active PDGF receptor See in Reactome R-HSA-382056 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382056 Reaction Name: Crk binds to the active PDGF receptor See in Reactome R-HSA-382058 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382058 Reaction Name: Nck binds to the active PDGF receptor See in Reactome R-HSA-389086 ( R-HSA-186797 ) R-HSA-389086 Reaction Name: Autophosphorylation of PDGF alpha/beta receptors See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864036 ( R-HSA-186797 ) R-HSA-8864036 Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021 See in Reactome R-HSA-9674095 ( R-HSA-186797 ) R-HSA-9674095 Reaction Name: PDGFRs bind type II TKI See in Reactome
MONDO:0008546	FGFR3	P22607	2.7.10.1	R-HSA-190372 R-HSA-190372 Reactome Name: FGFR3c ligand binding and activation See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654227 R-HSA-5654227 Reactome Name: Phospholipase C-mediated cascade; FGFR3 See in Reactome R-HSA-190371 R-HSA-190371 Reactome Name: FGFR3b ligand binding and activation See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-190239 R-HSA-190239 Reactome Name: FGFR3 ligand binding and activation See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-2404192; R-HSA-2428928 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190261 ( R-HSA-190372 ) R-HSA-190261 Reaction Name: FGFR3c binds to FGF See in Reactome R-HSA-190263 ( R-HSA-190371 ) R-HSA-190263 Reaction Name: FGFR3b binds to FGF See in Reactome R-HSA-190385 ( R-HSA-190371 ) R-HSA-190385 Reaction Name: Autocatalytic phosphorylation of FGFR3b See in Reactome R-HSA-190388 ( R-HSA-190372 ) R-HSA-190388 Reaction Name: Autocatalytic phosphorylation of FGFR3c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654148 ( R-HSA-5654227 ) R-HSA-5654148 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3 See in Reactome R-HSA-5654222 ( R-HSA-5654227 ) R-HSA-5654222 Reaction Name: Activated FGFR3 phosphorylates PLCG1 See in Reactome R-HSA-5654224 ( R-HSA-5654227 ) R-HSA-5654224 Reaction Name: Activated FGFR3 binds PLCG1 See in Reactome R-HSA-5654408 ( R-HSA-5654706 ) R-HSA-5654408 Reaction Name: Activated FGFR3 phosphorylates FRS2 See in Reactome R-HSA-5654409 ( R-HSA-5654706 ) R-HSA-5654409 Reaction Name: Activated FGFR3 binds FRS2 See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654416 ( R-HSA-5654706 ) R-HSA-5654416 Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654623 ( R-HSA-5654706 ) R-HSA-5654623 Reaction Name: Activated FGFR3 binds FRS3 See in Reactome R-HSA-5654625 ( R-HSA-5654704 ) R-HSA-5654625 Reaction Name: Activated FGFR3 binds SHC1 See in Reactome R-HSA-5654628 ( R-HSA-5654706 ) R-HSA-5654628 Reaction Name: Activated FGFR3 phosphorylates FRS3 See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654634 ( R-HSA-5654704 ) R-HSA-5654634 Reaction Name: Activated FGFR3 phosphorylates SHC1 See in Reactome R-HSA-5654637 ( R-HSA-5654710 ) R-HSA-5654637 Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654646 ( R-HSA-5654704 ) R-HSA-5654646 Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0014223	ERBB4	Q15303	2.7.10.1	R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Neuronal System Signal Transduction	R-HSA-1236398 ( R-HSA-1236394 ) R-HSA-1236398 Reaction Name: ERBB4 binds NRGs or EGF-like ligands See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250220 ( R-HSA-1236394 ) R-HSA-1250220 Reaction Name: Homodimerization of ERBB4 See in Reactome R-HSA-1250315 ( R-HSA-1236394 ) R-HSA-1250315 Reaction Name: Trans-autophosphorylation of ERBB4 homodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250348 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250348 Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250357 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250357 Reaction Name: SHC1 binds P-ERBB4 isoform dimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250380 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250380 Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1251992 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1251992 Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17 See in Reactome R-HSA-1251997 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-1253282 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1253282 Reaction Name: ERBB4 ubiquitination by WWP1/ITCH See in Reactome R-HSA-1253300 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1253300 Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases See in Reactome R-HSA-1253319 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253319 Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus See in Reactome R-HSA-1253321 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253321 Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 See in Reactome R-HSA-1253325 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253325 Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex See in Reactome R-HSA-1253343 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253343 Reaction Name: WWOX binds ERBB4s80 See in Reactome R-HSA-1254248 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254248 Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus See in Reactome R-HSA-1254251 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254251 Reaction Name: ERBB4s80 binds YAP1 See in Reactome R-HSA-1254285 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254285 Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus See in Reactome R-HSA-1254290 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254290 Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A See in Reactome R-HSA-1254291 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254291 Reaction Name: ERBB4s80 binds STAT5A See in Reactome R-HSA-1254376 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254376 Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix See in Reactome R-HSA-1254386 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-1254386 Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1 See in Reactome R-HSA-1254392 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-1254392 Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1973956 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1973956 Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer See in Reactome R-HSA-1977296 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1977296 Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer See in Reactome R-HSA-1977958 ( R-HSA-1236394 ) R-HSA-1977958 Reaction Name: ERBB4 forms heterodimers with ERBB3 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8954179 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954179 Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 See in Reactome R-HSA-8954182 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954182 Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter See in Reactome R-HSA-8954185 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954185 Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter See in Reactome R-HSA-8954199 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954199 Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen See in Reactome R-HSA-8954207 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954207 Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter See in Reactome R-HSA-8954208 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954208 Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter See in Reactome R-HSA-8954224 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954224 Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9612243 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612243 Reaction Name: APOE gene transcription is stimulated by ERBB4s80 See in Reactome R-HSA-9612246 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612246 Reaction Name: ERBB4s80 binds the APOE gene See in Reactome R-HSA-9612255 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612255 Reaction Name: ERBB4s80 binds ADAP1 gene See in Reactome R-HSA-9612257 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612257 Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80 See in Reactome R-HSA-9612277 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612277 Reaction Name: SPARC gene transcription is stimulated by ERBB4s80 See in Reactome R-HSA-9612278 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612278 Reaction Name: ERBB4s80 binds SPARC gene See in Reactome R-HSA-9612440 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612440 Reaction Name: ERBB4s80 binds the MXD4 gene See in Reactome R-HSA-9612444 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612444 Reaction Name: ERBB4s80 binds STMN1 gene See in Reactome R-HSA-9612445 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612445 Reaction Name: STMN1 gene expression is stimulated by ERBB4s80 See in Reactome R-HSA-9612448 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612448 Reaction Name: MXD4 gene expression is stimulated by ERBB4s80 See in Reactome R-HSA-9612593 ( R-HSA-1236394 ) R-HSA-9612593 Reaction Name: ERBB4 binds DLG4 See in Reactome R-HSA-9612639 ( R-HSA-1236394 ) R-HSA-9612639 Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1 See in Reactome R-HSA-9612671 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612671 Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1 See in Reactome R-HSA-9612672 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612672 Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter See in Reactome
MONDO:0019314	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0008244	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0005097	DDR2	Q16832	2.7.10.1	R-HSA-3000171 R-HSA-3000171 Reactome Name: Non-integrin membrane-ECM interactions See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-2465890 ( R-HSA-3000171 ) R-HSA-2465890 Reaction Name: DDR2 binds collagen type I, II, III, V, X fibrils See in Reactome
MONDO:0012552	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome
MONDO:0020511	FLT3	P36888	2.7.10.1	R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Immune System Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6786789 ( R-HSA-9607240 ) R-HSA-6786789 Reaction Name: FLT3LG dimer binds FLT3 See in Reactome R-HSA-8854736 ( R-HSA-9607240 ) R-HSA-8854736 Reaction Name: FLT3LG dimer:FLT3 binds FLT3 See in Reactome R-HSA-9604738 ( R-HSA-9607240 ) R-HSA-9604738 Reaction Name: Active FLT3 dimer binds GRB2 See in Reactome R-HSA-9604767 ( R-HSA-9607240 ) R-HSA-9604767 Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9605259 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9605259 Reaction Name: Active FLT3 binds FYN See in Reactome R-HSA-9606622 ( R-HSA-9607240 ) R-HSA-9606622 Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated See in Reactome R-HSA-9606624 ( R-HSA-9607240 ) R-HSA-9606624 Reaction Name: Active FLT3:GRB2 binds GAB2 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9607224 ( R-HSA-9607240 ) R-HSA-9607224 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 See in Reactome R-HSA-9607301 ( R-HSA-9607240 ) R-HSA-9607301 Reaction Name: Active FLT3:GRB2 binds SOS1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9609274 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9609274 Reaction Name: Active FLT3 binds HCK See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9695828 ( R-HSA-9607240 ) R-HSA-9695828 Reaction Name: FLT3 binds type I TKI See in Reactome R-HSA-9695831 ( R-HSA-9607240 ) R-HSA-9695831 Reaction Name: FLT3 binds type II TKI See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9698408 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9698408 Reaction Name: PTPRJ dephosphorylates active FLT3 See in Reactome R-HSA-9699578 ( R-HSA-9607240 ) R-HSA-9699578 Reaction Name: Active FLT3 phosphorylates CDKN1B See in Reactome R-HSA-9706287 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706287 Reaction Name: Active FLT3 binds to ABL2 See in Reactome R-HSA-9706293 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706298 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706298 Reaction Name: Active FLT3 binds to CSK See in Reactome R-HSA-9706304 ( R-HSA-9607240 ) R-HSA-9706304 Reaction Name: Active FLT3 binds to GRAP2 See in Reactome R-HSA-9706308 ( R-HSA-9607240 ) R-HSA-9706308 Reaction Name: Active FLT3 binds to GRB10 See in Reactome R-HSA-9706312 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome R-HSA-9706315 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706315 Reaction Name: Active FLT3 binds to SH2B3 See in Reactome R-HSA-9706319 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706319 Reaction Name: Active FLT3 binds to SLA See in Reactome R-HSA-9706323 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706323 Reaction Name: Active FLT3 binds to SLA2 See in Reactome R-HSA-9706328 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706328 Reaction Name: Active FLT3 binds to SOCS2 See in Reactome R-HSA-9706330 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706330 Reaction Name: Active FLT3 binds to SOCS6 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9706340 ( R-HSA-9607240 ) R-HSA-9706340 Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1 See in Reactome R-HSA-9706344 ( R-HSA-9607240 ) R-HSA-9706344 Reaction Name: FLT3 phosphorylates GRB10 See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706350 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome R-HSA-9706364 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706364 Reaction Name: Internalization of ubiquitinated FLT3 See in Reactome
MONDO:0020493	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome
MONDO:0015555	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 <