DAR - Bologna Biocomputing Group

Search summary (EC number: 2.7.1.78)

Number of enzymes:	2
Number of disease:	5
Number of reactomes:	6
Number of reactions:	17

Search results (EC number: 2.7.1.78)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011570	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0013254	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0013389	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0014349	CLP1	Q92989	2.7.1.78	R-HSA-77595 R-HSA-77595 Reactome Name: Processing of Intronless Pre-mRNAs See in Reactome R-HSA-72187 R-HSA-72187 Reactome Name: mRNA 3'-end processing See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-6784531 R-HSA-6784531 Reactome Name: tRNA processing in the nucleus See in Reactome R-HSA-73856 R-HSA-73856 Reactome Name: RNA Polymerase II Transcription Termination See in Reactome	R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-75067 R-HSA-75067 Reactome Name: Processing of Capped Intronless Pre-mRNA See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-5696813 ( R-HSA-6784531 ) R-HSA-5696813 Reaction Name: TSEN complex cleaves the intron from pre-tRNA See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-72180 ( R-HSA-72187; R-HSA-73856 ) R-HSA-72180 Reaction Name: Cleavage of mRNA at the 3'-end See in Reactome R-HSA-72231 ( R-HSA-72163 ) R-HSA-72231 Reaction Name: Formation of the Cleavage and Polyadenylation Complex See in Reactome R-HSA-77591 ( R-HSA-77595 ) R-HSA-77591 Reaction Name: Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex See in Reactome R-HSA-77592 ( R-HSA-73856; R-HSA-77595 ) R-HSA-77592 Reaction Name: Cleavage of Intronless Pre-mRNA at 3'-end See in Reactome R-HSA-77593 ( R-HSA-77595 ) R-HSA-77593 Reaction Name: Cleavage and polyadenylation of Intronless Pre-mRNA See in Reactome R-HSA-8849157 ( R-HSA-72187 ) R-HSA-8849157 Reaction Name: TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally See in Reactome
MONDO:0014557	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome