MONDO:0007576 |
RNF6 |
Q9Y252 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0015446 |
RNF213 |
Q63HN8 |
2.3.2.-
3.6.4.-
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0014439 |
TRIM32 |
Q13049 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-3134975
R-HSA-3134975
Reactome Name: Regulation of innate immune responses to cytosolic DNA
See in Reactome
|
R-HSA-168249
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-1280218
|
Immune System
|
R-HSA-1964496
(
R-HSA-3134975
)
R-HSA-3134804
(
R-HSA-3134975
)
R-HSA-3134804
Reaction Name: STING ubiquitination by TRIM32 or TRIM56
See in Reactome
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0032572 |
TRAF7 |
Q6Q0C0 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0013753 |
LRSAM1 |
Q6UWE0 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0010495 |
RNF113A |
O15541 |
2.3.2.27
|
|
|
|
|
MONDO:0013685 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0015713 |
MKRN3 |
Q13064 |
2.3.2.27
|
|
|
|
|
MONDO:0012359 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0019004 |
MONDO:0019004
Disease Name: kidney Wilms tumor
OMIM id: OMIM:616806
Orphanet id: Orphanet:654
All associated enzymes in DAR:
TRIM28
. The disease is also associated to other non-enzyme proteins (not in DAR).
TRIM28 |
Q13263 |
2.3.2.27
|
R-HSA-212436
R-HSA-3899300
R-HSA-3899300
Reactome Name: SUMOylation of transcription cofactors
See in Reactome
|
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-392499
R-HSA-2990846
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
|
R-HSA-3782535
(
R-HSA-3899300
)
R-HSA-3782535
Reaction Name: TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1
See in Reactome
R-HSA-975040
(
R-HSA-212436
)
|
MONDO:0034106 |
RNF13 |
O43567 |
2.3.2.27
|
|
|
|
|
MONDO:0011450 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0020333 |
CBL |
P22681 |
2.3.2.27
|
R-HSA-1059683
R-HSA-1433559
R-HSA-912631
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-182971
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-9706369
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-8856828
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
|
R-HSA-8848021
R-HSA-449147
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-190236
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-1433557
R-HSA-199991
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-177929
R-HSA-5653656
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-162582
|
Immune System
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1295621
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295621
Reaction Name: CBL dissociates from ubiquitinated p-SPRY2
See in Reactome
R-HSA-1295622
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-182969
(
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182988
(
R-HSA-182971
)
R-HSA-182988
Reaction Name: Sprouty lures CBL away from EGFR
See in Reactome
R-HSA-182990
(
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-182971
)
R-HSA-183052
(
R-HSA-182971
)
R-HSA-183055
(
R-HSA-182971
)
R-HSA-183058
(
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-205244
(
R-HSA-1433559
)
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-879917
(
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8848818
(
R-HSA-8849469
)
R-HSA-8848829
(
R-HSA-8849469
)
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-912627
(
R-HSA-912631
)
R-HSA-912629
(
R-HSA-912631
)
R-HSA-912724
(
R-HSA-912631
)
R-HSA-912724
Reaction Name: CBL binds B-cell linker protein
See in Reactome
R-HSA-912727
(
R-HSA-912631
)
R-HSA-912734
(
R-HSA-912631
)
R-HSA-912790
(
R-HSA-912631
)
R-HSA-934604
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-934604
Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL
See in Reactome
R-HSA-9706293
(
R-HSA-9706369
)
R-HSA-9706350
(
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9706369
)
|
MONDO:0016419 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0013308 |
CBL |
P22681 |
2.3.2.27
|
R-HSA-1059683
R-HSA-1433559
R-HSA-912631
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-182971
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-9706369
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-8856828
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
|
R-HSA-8848021
R-HSA-449147
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-190236
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-1433557
R-HSA-199991
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-177929
R-HSA-5653656
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-162582
|
Immune System
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1295621
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295621
Reaction Name: CBL dissociates from ubiquitinated p-SPRY2
See in Reactome
R-HSA-1295622
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-182969
(
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182988
(
R-HSA-182971
)
R-HSA-182988
Reaction Name: Sprouty lures CBL away from EGFR
See in Reactome
R-HSA-182990
(
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-182971
)
R-HSA-183052
(
R-HSA-182971
)
R-HSA-183055
(
R-HSA-182971
)
R-HSA-183058
(
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-205244
(
R-HSA-1433559
)
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-879917
(
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8848818
(
R-HSA-8849469
)
R-HSA-8848829
(
R-HSA-8849469
)
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-912627
(
R-HSA-912631
)
R-HSA-912629
(
R-HSA-912631
)
R-HSA-912724
(
R-HSA-912631
)
R-HSA-912724
Reaction Name: CBL binds B-cell linker protein
See in Reactome
R-HSA-912727
(
R-HSA-912631
)
R-HSA-912734
(
R-HSA-912631
)
R-HSA-912790
(
R-HSA-912631
)
R-HSA-934604
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-934604
Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL
See in Reactome
R-HSA-9706293
(
R-HSA-9706369
)
R-HSA-9706350
(
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9706369
)
|
MONDO:0100062 |
TRIM8 |
Q9BZR9 |
2.3.2.27
|
R-HSA-877300
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
|
Immune System
|
R-HSA-1031716
(
R-HSA-877300
)
R-HSA-1031716
Reaction Name: Expression of IFNG-stimulated genes
See in Reactome
|
MONDO:0016642 |
TRAF7 |
Q6Q0C0 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0007763 |
RNF139 |
Q8WU17 |
2.3.2.27
|
R-HSA-901032
R-HSA-901032
Reactome Name: ER Quality Control Compartment (ERQC)
See in Reactome
|
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-901042
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Metabolism of proteins
|
R-HSA-8867288
(
R-HSA-901032
)
R-HSA-8867288
Reaction Name: OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5
See in Reactome
|
MONDO:0032862 |
TRIM71 |
Q2Q1W2 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0032868 |
MDM2 |
Q00987 |
2.3.2.27
|
R-HSA-2559585
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-3232118
R-HSA-3232118
Reactome Name: SUMOylation of transcription factors
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-3232142
R-HSA-3232142
Reactome Name: SUMOylation of ubiquitinylation proteins
See in Reactome
R-HSA-399719
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-69541
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73857
R-HSA-69620
R-HSA-5633007
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-2262752
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-2990846
R-HSA-112316
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-8953897
R-HSA-392499
R-HSA-399721
R-HSA-399721
Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-5688426
R-HSA-69615
R-HSA-162582
|
Cell Cycle
Gene expression (Transcription)
Neuronal System
Cellular responses to stimuli
Metabolism of proteins
Signal Transduction
|
R-HSA-198599
(
R-HSA-198323;
R-HSA-6804757
)
R-HSA-2997706
(
R-HSA-3232118
)
R-HSA-2997706
Reaction Name: MDM2 SUMOylates TP53 with SUMO2,3
See in Reactome
R-HSA-3000434
(
R-HSA-3232142
)
R-HSA-3000434
Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1
See in Reactome
R-HSA-3215295
(
R-HSA-6804757
)
R-HSA-3222072
(
R-HSA-6804757
)
R-HSA-349426
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-349426
Reaction Name: Phosphorylation of MDM4 by CHEK2
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-3700992
(
R-HSA-6804757
)
R-HSA-3700992
Reaction Name: TP53 stimulates MDM2 transcription
See in Reactome
R-HSA-416320
(
R-HSA-399719
)
R-HSA-416320
Reaction Name: Trafficking of GluR1-containing AMPA receptors
See in Reactome
R-HSA-5228523
(
R-HSA-3232142
)
R-HSA-5228523
Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1
See in Reactome
R-HSA-5633460
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-5689972
(
R-HSA-5689880;
R-HSA-6804757
)
R-HSA-5689972
Reaction Name: USP2 deubiquitinates MDM2,MDM4
See in Reactome
R-HSA-6792863
(
R-HSA-6804757
)
R-HSA-6792863
Reaction Name: PP2A-PP2R5C dephosphorylates MDM2
See in Reactome
R-HSA-6792871
(
R-HSA-6804757
)
R-HSA-6792871
Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2
See in Reactome
R-HSA-6793661
(
R-HSA-6804757
)
R-HSA-6793661
Reaction Name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218
See in Reactome
R-HSA-6793666
(
R-HSA-6804757
)
R-HSA-6793666
Reaction Name: MDM2 translocates to the nucleus
See in Reactome
R-HSA-6795460
(
R-HSA-6804757
)
R-HSA-6795667
(
R-HSA-6804757
)
R-HSA-6795667
Reaction Name: MDM2 translocates to the cytosol
See in Reactome
R-HSA-6798373
(
R-HSA-6804756
)
R-HSA-6804253
(
R-HSA-6804760
)
R-HSA-6804724
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804724
Reaction Name: MDM2 ubiquitinates phosphorylated MDM4
See in Reactome
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804879
(
R-HSA-2559580;
R-HSA-2559585;
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804942
(
R-HSA-6804757
)
R-HSA-6804942
Reaction Name: MDM2 homodimers auto-ubiquitinate
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804996
(
R-HSA-2559580;
R-HSA-2559585;
R-HSA-6804757
)
R-HSA-6804998
(
R-HSA-2559580;
R-HSA-2559585;
R-HSA-6804757
)
R-HSA-6804998
Reaction Name: p14ARF forms a ternary complex with MDM2 and TP53
See in Reactome
R-HSA-6805022
(
R-HSA-6804757
)
R-HSA-6805022
Reaction Name: USP2 binds the heterodimer of MDM2 and MDM4
See in Reactome
R-HSA-8952371
(
R-HSA-8941858
)
R-HSA-8952382
(
R-HSA-8941858
)
|
MONDO:0015884 |
TRAF6 |
Q9Y4K3 |
2.3.2.27
|
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9020702
R-HSA-1257604
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-933541
R-HSA-202424
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-168638
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-937039
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975110
R-HSA-975110
Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-448424
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-193639
R-HSA-166166
R-HSA-450294
R-HSA-5688426
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-166869
(
R-HSA-166058;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-177694
(
R-HSA-9014325
)
R-HSA-177694
Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193665
(
R-HSA-209543
)
R-HSA-193669
(
R-HSA-205043
)
R-HSA-193684
(
R-HSA-209543
)
R-HSA-193694
(
R-HSA-209543
)
R-HSA-193694
Reaction Name: p62 is recruited and forms a complex with TRAF6
See in Reactome
R-HSA-193695
(
R-HSA-209543
)
R-HSA-193700
(
R-HSA-193692
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202453
(
R-HSA-202424
)
R-HSA-202472
(
R-HSA-202424
)
R-HSA-202472
Reaction Name: Translocation of TRAF6 to CBM complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-204949
(
R-HSA-205043
)
R-HSA-204949
Reaction Name: NRIF and TRAF6 may activate JNK
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-205118
(
R-HSA-205043
)
R-HSA-209566
(
R-HSA-209543
)
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730864
(
R-HSA-2871837
)
R-HSA-2730864
Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-2730903
(
R-HSA-2871837
)
R-HSA-2730904
(
R-HSA-2871837
)
R-HSA-446862
(
R-HSA-9020702
)
R-HSA-446862
Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6
See in Reactome
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-446877
(
R-HSA-9020702
)
R-HSA-446877
Reaction Name: TRAF6 is K63 poly-ubiquitinated
See in Reactome
R-HSA-446894
(
R-HSA-9020702
)
R-HSA-446894
Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release
See in Reactome
R-HSA-450173
(
R-HSA-9020702
)
R-HSA-450173
Reaction Name: IRAK1 induces oligomerisation of TRAF6
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450259
(
R-HSA-9014325
)
R-HSA-450259
Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
See in Reactome
R-HSA-450337
(
R-HSA-166058;
R-HSA-450321;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-166058;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-450358
(
R-HSA-937072;
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-450358
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
See in Reactome
R-HSA-507719
(
R-HSA-9020702
)
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607747
(
R-HSA-5607764
)
R-HSA-5607751
(
R-HSA-5607764
)
R-HSA-5607756
(
R-HSA-5607764
)
R-HSA-5607756
Reaction Name: TRAF6 oligomer autoubiquitinates
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-688137
(
R-HSA-168638
)
R-HSA-741386
(
R-HSA-168638
)
R-HSA-741386
Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO
See in Reactome
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-8869456
(
R-HSA-5689880
)
R-HSA-8869456
Reaction Name: USP4 deubiquitinate TRAF2,TRAF6
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-8948015
(
R-HSA-9020702
)
R-HSA-8948015
Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
See in Reactome
R-HSA-8948018
(
R-HSA-9020702
)
R-HSA-8948018
Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-918230
(
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-933525
(
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933537
(
R-HSA-933541
)
R-HSA-933538
(
R-HSA-933541
)
R-HSA-936942
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936942
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936952
(
R-HSA-937072
)
R-HSA-936952
Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936963
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936963
Reaction Name: IRAK2 induces TRAF6 oligomerization
See in Reactome
R-HSA-936985
(
R-HSA-937072
)
R-HSA-936985
Reaction Name: Activated TLR4:TICAM1 recruits TRAF6
See in Reactome
R-HSA-936986
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936986
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains
See in Reactome
R-HSA-936991
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937032
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-937034
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937044
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937050
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9628444
(
R-HSA-9014325
)
R-HSA-9628444
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
See in Reactome
R-HSA-9645394
(
R-HSA-9645460
)
R-HSA-9645394
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645414
(
R-HSA-9645460
)
R-HSA-9645414
Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-9645501
(
R-HSA-9645460
)
R-HSA-9645501
Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex
See in Reactome
R-HSA-9645520
(
R-HSA-9645460
)
R-HSA-9645520
Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
See in Reactome
R-HSA-9705145
(
R-HSA-933541
)
R-HSA-9705323
(
R-HSA-933541
)
R-HSA-975097
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975100
(
R-HSA-975138;
R-HSA-975155
)
R-HSA-975100
Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975103
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975106
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975106
Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975111
(
R-HSA-975155
)
R-HSA-975111
Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
See in Reactome
R-HSA-975118
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975118
Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975119
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
R-HSA-975122
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975122
Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>
See in Reactome
R-HSA-975139
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975139
Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975142
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975142
Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975147
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975147
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
See in Reactome
R-HSA-975185
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975185
Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
See in Reactome
R-HSA-975188
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975188
Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975857
(
R-HSA-975871
)
R-HSA-975857
Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2
See in Reactome
R-HSA-975879
(
R-HSA-975871
)
R-HSA-975879
Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
See in Reactome
|
MONDO:0011908 |
CBL |
P22681 |
2.3.2.27
|
R-HSA-1059683
R-HSA-1433559
R-HSA-912631
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-182971
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-9706369
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-8856828
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
|
R-HSA-8848021
R-HSA-449147
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-190236
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-1433557
R-HSA-199991
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-177929
R-HSA-5653656
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-162582
|
Immune System
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1295621
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295621
Reaction Name: CBL dissociates from ubiquitinated p-SPRY2
See in Reactome
R-HSA-1295622
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-182969
(
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182988
(
R-HSA-182971
)
R-HSA-182988
Reaction Name: Sprouty lures CBL away from EGFR
See in Reactome
R-HSA-182990
(
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-182971
)
R-HSA-183052
(
R-HSA-182971
)
R-HSA-183055
(
R-HSA-182971
)
R-HSA-183058
(
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-205244
(
R-HSA-1433559
)
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-879917
(
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8848818
(
R-HSA-8849469
)
R-HSA-8848829
(
R-HSA-8849469
)
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-912627
(
R-HSA-912631
)
R-HSA-912629
(
R-HSA-912631
)
R-HSA-912724
(
R-HSA-912631
)
R-HSA-912724
Reaction Name: CBL binds B-cell linker protein
See in Reactome
R-HSA-912727
(
R-HSA-912631
)
R-HSA-912734
(
R-HSA-912631
)
R-HSA-912790
(
R-HSA-912631
)
R-HSA-934604
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-934604
Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL
See in Reactome
R-HSA-9706293
(
R-HSA-9706369
)
R-HSA-9706350
(
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9706369
)
|
MONDO:0019448 |
MARCHF6 |
O60337 |
2.3.2.27
|
R-HSA-901032
R-HSA-901032
Reactome Name: ER Quality Control Compartment (ERQC)
See in Reactome
|
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-901042
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Metabolism of proteins
|
R-HSA-8867288
(
R-HSA-901032
)
R-HSA-8867288
Reaction Name: OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5
See in Reactome
|
MONDO:0008170 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0035363 |
IRF2BPL |
Q9H1B7 |
2.3.2.27
|
|
|
|
|
MONDO:0015356 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0030963 |
UBR7 |
Q8N806 |
2.3.2.27
|
|
|
|
|
MONDO:0000561 |
STUB1 |
Q9UNE7 |
2.3.2.27
|
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
|
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-5218859
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-6807070
R-HSA-1227986
R-HSA-5357801
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-1918092
(
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-2187368
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2187368
Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3
See in Reactome
R-HSA-2187375
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9009308
(
R-HSA-8939902
)
R-HSA-9009309
(
R-HSA-8939902
)
R-HSA-9688831
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688831
Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363
See in Reactome
R-HSA-9688838
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0014137 |
MKRN3 |
Q13064 |
2.3.2.27
|
|
|
|
|
MONDO:0011338 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0009683 |
TRIM32 |
Q13049 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-3134975
R-HSA-3134975
Reactome Name: Regulation of innate immune responses to cytosolic DNA
See in Reactome
|
R-HSA-168249
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-1280218
|
Immune System
|
R-HSA-1964496
(
R-HSA-3134975
)
R-HSA-3134804
(
R-HSA-3134975
)
R-HSA-3134804
Reaction Name: STING ubiquitination by TRIM32 or TRIM56
See in Reactome
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0012764 |
RNF168 |
Q8IYW5 |
2.3.2.27
|
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-69473
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
|
R-HSA-69481
R-HSA-69620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-392499
R-HSA-5693538
R-HSA-1640170
R-HSA-2990846
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
Cell Cycle
DNA Repair
|
R-HSA-4551661
(
R-HSA-3108214
)
R-HSA-4551661
Reaction Name: PIAS4 SUMOylates RNF168 with SUMO1
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
|
MONDO:0010222 |
MID1 |
O15344 |
2.3.2.27
|
R-HSA-877300
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
|
Immune System
|
R-HSA-1031716
(
R-HSA-877300
)
R-HSA-1031716
Reaction Name: Expression of IFNG-stimulated genes
See in Reactome
|
MONDO:0008791 |
TRIM36 |
Q9NQ86 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0014919 |
RNF43 |
Q68DV7 |
2.3.2.27
|
R-HSA-4641263
R-HSA-4641263
Reactome Name: Regulation of FZD by ubiquitination
See in Reactome
|
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-195721
R-HSA-162582
|
Signal Transduction
|
R-HSA-4641205
(
R-HSA-4641263
)
R-HSA-4641246
(
R-HSA-4641263
)
R-HSA-4641246
Reaction Name: ZNRF3 autoubiquitinates to promote its internalization
See in Reactome
R-HSA-4641249
(
R-HSA-4641263
)
R-HSA-4641249
Reaction Name: ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
See in Reactome
R-HSA-4641253
(
R-HSA-4641263
)
R-HSA-4641253
Reaction Name: ZNRF3 ubiquitinates FZD to promote its downregulation
See in Reactome
|
MONDO:0010385 |
XIAP |
P98170 |
2.3.2.27
|
R-HSA-111469
R-HSA-111469
Reactome Name: SMAC, XIAP-regulated apoptotic response
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-111464
R-HSA-111464
Reactome Name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-111463
R-HSA-5357905
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111459
R-HSA-111459
Reactome Name: Activation of caspases through apoptosome-mediated cleavage
See in Reactome
|
R-HSA-195721
R-HSA-1257604
R-HSA-6807070
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-5357801
R-HSA-5218859
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-109581
R-HSA-73887
R-HSA-75893
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-111458
R-HSA-162582
|
Programmed Cell Death
Signal Transduction
|
R-HSA-114252
(
R-HSA-111459
)
R-HSA-114252
Reaction Name: Cleavage of Procaspase-3 by the apoptosome
See in Reactome
R-HSA-114261
(
R-HSA-111459
)
R-HSA-114261
Reaction Name: Cleavage of Procaspase-7 by the apoptosome
See in Reactome
R-HSA-114306
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114354
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114361
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114361
Reaction Name: SMAC binds XIAP within apoptosome
See in Reactome
R-HSA-114392
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114392
Reaction Name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
See in Reactome
R-HSA-114419
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114419
Reaction Name: Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3
See in Reactome
R-HSA-114440
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114440
Reaction Name: Dissociation of DIABLO:XIAP from the apoptosome complex
See in Reactome
R-HSA-3322429
(
R-HSA-3769402
)
R-HSA-3322431
(
R-HSA-3769402
)
R-HSA-3322434
(
R-HSA-3769402
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357928
(
R-HSA-5357905
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5675470
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-5675470
Reaction Name: BIRC2/3 (cIAP1/2) is autoubiquitinated
See in Reactome
R-HSA-5693055
(
R-HSA-5357905
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9627078
(
R-HSA-9627069
)
R-HSA-9627104
(
R-HSA-111469
)
R-HSA-9627107
(
R-HSA-111469
)
R-HSA-9627350
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-9627369
(
R-HSA-111469
)
|
MONDO:0013554 |
TRAF3IP2 |
O43734 |
2.3.2.27
|
|
|
|
|
MONDO:0012166 |
RNF170 |
Q96K19 |
2.3.2.27
|
|
|
|
|
MONDO:0060596 |
RLIM |
Q9NVW2 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0012367 |
TOPORS |
Q9NS56 |
2.3.2.27
|
R-HSA-4755510
R-HSA-4755510
Reactome Name: SUMOylation of immune response proteins
See in Reactome
R-HSA-3899300
R-HSA-3899300
Reactome Name: SUMOylation of transcription cofactors
See in Reactome
R-HSA-4085377
R-HSA-4085377
Reactome Name: SUMOylation of SUMOylation proteins
See in Reactome
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-2990846
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-4085994
(
R-HSA-3899300
)
R-HSA-4085994
Reaction Name: TOPORS SUMOylates SIN3A with SUMO1
See in Reactome
R-HSA-4551683
(
R-HSA-4085377
)
R-HSA-4551683
Reaction Name: SUMOylation of TOPORS with SUMO1
See in Reactome
R-HSA-4755478
(
R-HSA-4755510
)
R-HSA-4755478
Reaction Name: TOPORS SUMOylates IKBKE with SUMO1
See in Reactome
|
MONDO:0011086 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0032526 |
STUB1 |
Q9UNE7 |
2.3.2.27
|
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
|
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-5218859
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-6807070
R-HSA-1227986
R-HSA-5357801
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-1918092
(
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-2187368
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2187368
Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3
See in Reactome
R-HSA-2187375
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9009308
(
R-HSA-8939902
)
R-HSA-9009309
(
R-HSA-8939902
)
R-HSA-9688831
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688831
Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363
See in Reactome
R-HSA-9688838
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0009664 |
TRIM37 |
O94972 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0001149 |
MONDO:0001149
Disease Name: microcephaly
OMIM id: OMIM:612703
All associated enzymes in DAR:
DHCR7
UFSP2
PLA2G6
SLC2A1
RAG1
ALG13
DHX34
ATRX
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0014767 |
TRAIP |
Q9BWF2 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0060759 |
IRF2BPL |
Q9H1B7 |
2.3.2.27
|
|
|
|
|
MONDO:0054748 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0044325 |
RFWD3 |
Q6PCD5 |
2.3.2.27
|
|
|
|
|
MONDO:0014230 |
TRAF3IP2 |
O43734 |
2.3.2.27
|
|
|
|
|
MONDO:0010489 |
MID2 |
Q9UJV3 |
2.3.2.27
|
|
|
|
|
MONDO:0009479 |
UBR1 |
Q8IWV7 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0009306 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0015278 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0013566 |
FANCL |
Q9NW38 |
2.3.2.27
|
R-HSA-6783310
|
R-HSA-73894
|
DNA Repair
|
R-HSA-6785126
(
R-HSA-6783310
)
R-HSA-6785126
Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs)
See in Reactome
R-HSA-6785342
(
R-HSA-6783310
)
R-HSA-6785342
Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
See in Reactome
R-HSA-6785361
(
R-HSA-6783310
)
R-HSA-6785361
Reaction Name: Monoubiquitination of FANCD2:FANCI
See in Reactome
R-HSA-6785732
(
R-HSA-6783310
)
R-HSA-6785732
Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex
See in Reactome
R-HSA-6785986
(
R-HSA-6783310
)
R-HSA-6785986
Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL)
See in Reactome
R-HSA-6786155
(
R-HSA-6783310
)
R-HSA-6786166
(
R-HSA-6783310
)
R-HSA-6786166
Reaction Name: Translesion synthesis across unhooked ICL by POLN
See in Reactome
R-HSA-6786171
(
R-HSA-6783310
)
R-HSA-6786171
Reaction Name: FANCD2 deubiquitination by USP1:WDR48
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
|
MONDO:0009697 |
MONDO:0009697
Disease Name: Lafora disease
OMIM id: OMIM:254780
Orphanet id: Orphanet:501
All associated enzymes in DAR:
NHLRC1
. The disease is also associated to other non-enzyme proteins (not in DAR).
NHLRC1 |
Q6VVB1 |
2.3.2.27
|
R-HSA-3322077
|
R-HSA-8982491
R-HSA-1430728
R-HSA-71387
|
Metabolism
|
R-HSA-3780995
(
R-HSA-3322077
)
R-HSA-3780995
Reaction Name: NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2
See in Reactome
R-HSA-3781009
(
R-HSA-3322077
)
R-HSA-3781009
Reaction Name: NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
See in Reactome
|
MONDO:0008104 |
CBL |
P22681 |
2.3.2.27
|
R-HSA-1059683
R-HSA-1433559
R-HSA-912631
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-182971
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-9706369
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-8856828
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
|
R-HSA-8848021
R-HSA-449147
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-190236
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-1433557
R-HSA-199991
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-177929
R-HSA-5653656
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-162582
|
Immune System
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1295621
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295621
Reaction Name: CBL dissociates from ubiquitinated p-SPRY2
See in Reactome
R-HSA-1295622
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-182969
(
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182988
(
R-HSA-182971
)
R-HSA-182988
Reaction Name: Sprouty lures CBL away from EGFR
See in Reactome
R-HSA-182990
(
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-182971
)
R-HSA-183052
(
R-HSA-182971
)
R-HSA-183055
(
R-HSA-182971
)
R-HSA-183058
(
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-205244
(
R-HSA-1433559
)
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-879917
(
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8848818
(
R-HSA-8849469
)
R-HSA-8848829
(
R-HSA-8849469
)
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-912627
(
R-HSA-912631
)
R-HSA-912629
(
R-HSA-912631
)
R-HSA-912724
(
R-HSA-912631
)
R-HSA-912724
Reaction Name: CBL binds B-cell linker protein
See in Reactome
R-HSA-912727
(
R-HSA-912631
)
R-HSA-912734
(
R-HSA-912631
)
R-HSA-912790
(
R-HSA-912631
)
R-HSA-934604
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-934604
Reaction Name: Phosphorylated SPRY2 is ubiquitinated by CBL
See in Reactome
R-HSA-9706293
(
R-HSA-9706369
)
R-HSA-9706350
(
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9706369
)
|
MONDO:0009215 |
BRCA1 |
P38398 |
2.3.2.27
|
R-HSA-8953750
R-HSA-8953750
Reactome Name: Transcriptional Regulation by E2F6
See in Reactome
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-912446
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-73894
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-1500620
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-69620
R-HSA-5688426
R-HSA-2990846
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-73857
|
DNA Repair
Gene expression (Transcription)
Metabolism of proteins
Cell Cycle
Reproduction
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9007605
(
R-HSA-8953750
)
R-HSA-9007605
Reaction Name: BRCA1 gene expression is inhibited by E2F6
See in Reactome
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912467
(
R-HSA-1221632
)
R-HSA-912467
Reaction Name: BRCA1 is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0033557 |
RC3H1 |
Q5TC82 |
2.3.2.27
|
|
|
|
|
MONDO:0014553 |
RNF125 |
Q96EQ8 |
2.3.2.27
|
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
|
Immune System
|
R-HSA-936412
(
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
|
MONDO:0013920 |
TRAF3 |
Q13114 |
2.3.2.27
|
R-HSA-9013973
R-HSA-9013973
Reactome Name: TICAM1-dependent activation of IRF3/IRF7
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5676594
R-HSA-5676594
Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-392499
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-5688426
R-HSA-166166
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-166245
(
R-HSA-936964
)
R-HSA-166245
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-2201338
(
R-HSA-936964
)
R-HSA-2201338
Reaction Name: TRAF3 binds TICAM1:activated TLR4 complex
See in Reactome
R-HSA-2213017
(
R-HSA-936964
)
R-HSA-5362486
(
R-HSA-936964
)
R-HSA-5362486
Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4
See in Reactome
R-HSA-5362500
(
R-HSA-936964
)
R-HSA-5362500
Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
See in Reactome
R-HSA-5668414
(
R-HSA-5668541
)
R-HSA-5668414
Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
See in Reactome
R-HSA-5668417
(
R-HSA-5668541
)
R-HSA-5668417
Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
See in Reactome
R-HSA-5668454
(
R-HSA-5668541
)
R-HSA-5668454
Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3
See in Reactome
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668534
(
R-HSA-5668541
)
R-HSA-5668534
Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
See in Reactome
R-HSA-5668543
(
R-HSA-5668541
)
R-HSA-5676593
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676593
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
See in Reactome
R-HSA-5676595
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676596
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
See in Reactome
R-HSA-5676598
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676598
Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK
See in Reactome
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-9013974
(
R-HSA-9013973
)
R-HSA-9013974
Reaction Name: Auto-ubiquitination of TRAF3 within activated TLR3 complex
See in Reactome
R-HSA-9013978
(
R-HSA-9013973
)
R-HSA-9013978
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
See in Reactome
R-HSA-9013979
(
R-HSA-9013973
)
R-HSA-9013979
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
See in Reactome
R-HSA-9013985
(
R-HSA-9013973
)
R-HSA-9013985
Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
See in Reactome
R-HSA-9013986
(
R-HSA-9013973
)
R-HSA-9013986
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
See in Reactome
R-HSA-9013990
(
R-HSA-9013973
)
R-HSA-9013990
Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
See in Reactome
R-HSA-9013992
(
R-HSA-9013973
)
R-HSA-9013992
Reaction Name: TRAF3 binds to TRIF:activated TLR3 complex
See in Reactome
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-936941
(
R-HSA-936964
)
R-HSA-936941
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
|
MONDO:0008935 |
RNF216 |
Q9NWF9 |
2.3.2.27
|
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
|
Immune System
|
R-HSA-936475
(
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
|
MONDO:0013322 |
MARCHF6 |
O60337 |
2.3.2.27
|
R-HSA-901032
R-HSA-901032
Reactome Name: ER Quality Control Compartment (ERQC)
See in Reactome
|
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-901042
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Metabolism of proteins
|
R-HSA-8867288
(
R-HSA-901032
)
R-HSA-8867288
Reaction Name: OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5
See in Reactome
|
MONDO:0017116 |
TRIM71 |
Q2Q1W2 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0013617 |
RNF135 |
Q8IUD6 |
2.3.2.27
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-918224
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0014208 |
TRIM2 |
Q9C040 |
2.3.2.27
|
R-HSA-877300
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-168256
|
Immune System
|
R-HSA-1031716
(
R-HSA-877300
)
R-HSA-1031716
Reaction Name: Expression of IFNG-stimulated genes
See in Reactome
|
MONDO:0014042 |
MIB1 |
Q86YT6 |
2.3.2.27
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-162582
R-HSA-157118
|
Signal Transduction
|
R-HSA-1980074
(
R-HSA-2122948
)
R-HSA-1980074
Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
See in Reactome
R-HSA-2172172
(
R-HSA-2979096
)
R-HSA-2172172
Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
See in Reactome
R-HSA-9013069
(
R-HSA-9013507
)
R-HSA-9013069
Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
See in Reactome
|
MONDO:0011784 |
RNF213 |
Q63HN8 |
2.3.2.-
3.6.4.-
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0010506 |
RLIM |
Q9NVW2 |
2.3.2.27
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0014339 |
STUB1 |
Q9UNE7 |
2.3.2.27
|
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
|
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-5218859
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-6807070
R-HSA-1227986
R-HSA-5357801
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-1918092
(
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-2187368
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2187368
Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3
See in Reactome
R-HSA-2187375
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9009308
(
R-HSA-8939902
)
R-HSA-9009309
(
R-HSA-8939902
)
R-HSA-9688831
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688831
Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363
See in Reactome
R-HSA-9688838
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|