DAR - Bologna Biocomputing Group

Search summary (EC number: 2.3.2.13)

Number of enzymes:	5
Number of disease:	11
Number of reactomes:	4
Number of reactions:	13

Search results (EC number: 2.3.2.13)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009441	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0012345	TGM5	O43548	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome
MONDO:0013187	F13A1	P00488	2.3.2.13	R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140847 ( R-HSA-140875 ) R-HSA-140847 Reaction Name: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain See in Reactome R-HSA-140851 ( R-HSA-140875 ) R-HSA-140851 Reaction Name: fibrin multimer -> fibrin multimer, crosslinked + NH4+ See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6785895 ( R-HSA-6785807 ) R-HSA-6785895 Reaction Name: Expression of IL4, IL13-upregulated extracellular proteins See in Reactome
MONDO:0013485	TGM6	O95932	2.3.2.13
MONDO:0014989	TGM3	Q08188	2.3.2.13
MONDO:0015085	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017267	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017268	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017778	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome
MONDO:0017893	TGM6	O95932	2.3.2.13
MONDO:0019306	TGM1	P22735	2.3.2.13	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-6810894 ( R-HSA-6809371 ) R-HSA-6810894 Reaction Name: Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking See in Reactome R-HSA-6810899 ( R-HSA-6809371 ) R-HSA-6810899 Reaction Name: TGM1 and involucrin bind the plasma membrane See in Reactome R-HSA-6810937 ( R-HSA-6809371 ) R-HSA-6810937 Reaction Name: Lamellar bodies bind the early cornified envelope See in Reactome R-HSA-6811539 ( R-HSA-6809371 ) R-HSA-6811539 Reaction Name: Reinforcement of the Cornified Envelope See in Reactome R-HSA-6814298 ( R-HSA-6809371 ) R-HSA-6814298 Reaction Name: Late envelope proteins bind cornified envelope:CDSN See in Reactome R-HSA-6814387 ( R-HSA-6809371 ) R-HSA-6814387 Reaction Name: CASP14 cleaves filaggrin See in Reactome R-HSA-6814734 ( R-HSA-6809371 ) R-HSA-6814734 Reaction Name: CDSN binds the cornified envelope See in Reactome R-HSA-6814764 ( R-HSA-6809371 ) R-HSA-6814764 Reaction Name: Plasma membrane resorption See in Reactome