Number of enzymes: | 1 |
Number of disease: | 1 |
Number of reactomes: | 2 |
Number of reactions: | 4 |
DiseaseID | Gene | UniProt | EC numbers | Reactomes | Expanded Reactomes | Reactome roots | Reactions |
---|---|---|---|---|---|---|---|
MONDO:0005387 | SIRT6 | Q8N6T7 | 2.3.1.286 |
R-HSA-1912408 R-HSA-5693607 |
R-HSA-5693567 R-HSA-5693567Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)See in Reactome R-HSA-5693538 R-HSA-73894 R-HSA-1912422 R-HSA-5693532 R-HSA-162582 |
DNA Repair Signal Transduction |
R-HSA-5685953
(
R-HSA-5693607
) R-HSA-9604829 ( R-HSA-1912408 ) R-HSA-9604829Reaction Name: SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promotersSee in Reactome R-HSA-9604831Reaction Name: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6See in Reactome R-HSA-9604834Reaction Name: SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promotersSee in Reactome |