DAR - Bologna Biocomputing Group

Search summary (EC number: 2.1.1.6)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	3
Number of reactions:	5

Search results (EC number: 2.1.1.6)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005090	COMT	P21964	2.1.1.6	R-HSA-379398 R-HSA-379398 Reactome Name: Enzymatic degradation of Dopamine by monoamine oxidase See in Reactome R-HSA-379397 R-HSA-379397 Reactome Name: Enzymatic degradation of dopamine by COMT See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-379401 R-HSA-379401 Reactome Name: Dopamine clearance from the synaptic cleft See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-112311 R-HSA-112311 Reactome Name: Neurotransmitter clearance See in Reactome	Metabolism Neuronal System	R-HSA-175983 ( R-HSA-156581 ) R-HSA-175983 Reaction Name: COMT transfer CH3 from AdoMet to 3,4DHBNZ See in Reactome R-HSA-379387 ( R-HSA-379397 ) R-HSA-379387 Reaction Name: COMT transfers Met to DA to form 3MT See in Reactome R-HSA-379464 ( R-HSA-379398 ) R-HSA-379464 Reaction Name: COMT transfers Met to DOPAC to form HVA See in Reactome R-HSA-9679775 ( R-HSA-379397 ) R-HSA-9679775 Reaction Name: COMT binds COMT Inhibitors See in Reactome
MONDO:0012670	TOMT	Q8WZ04	2.1.1.6	R-HSA-379397 R-HSA-379397 Reactome Name: Enzymatic degradation of dopamine by COMT See in Reactome	R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-379401 R-HSA-379401 Reactome Name: Dopamine clearance from the synaptic cleft See in Reactome R-HSA-112311 R-HSA-112311 Reactome Name: Neurotransmitter clearance See in Reactome	Neuronal System	R-HSA-8955010 ( R-HSA-379397 ) R-HSA-8955010 Reaction Name: LRTOMT transfers Met to DA, forming 3MT See in Reactome