DAR - Bologna Biocomputing Group

Search summary (EC number: 2.1.1.367)

Number of enzymes:	5
Number of disease:	7
Number of reactomes:	6
Number of reactions:	19

Search results (EC number: 2.1.1.367)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014152	PRDM16	Q9HAZ2	2.1.1.367	R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-5634802 ( R-HSA-3214841 ) R-HSA-5634802 Reaction Name: MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) See in Reactome
MONDO:0014336	SETD5	Q9C0A6	2.1.1.359 2.1.1.367
MONDO:0014758	MECOM	Q03112	2.1.1.367	R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Signal Transduction	R-HSA-5634802 ( R-HSA-3214841 ) R-HSA-5634802 Reaction Name: MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) See in Reactome R-HSA-8943811 ( R-HSA-8943724 ) R-HSA-8943811 Reaction Name: MECOM (EVI1) binds the PTEN gene promoter See in Reactome R-HSA-8943817 ( R-HSA-8943724 ) R-HSA-8943817 Reaction Name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome
MONDO:0016865	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0016996	SETD5	Q9C0A6	2.1.1.359 2.1.1.367
MONDO:0027407	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0030918	ASH1L	Q9NR48	2.1.1.359 2.1.1.367	R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-4827383 ( R-HSA-3214841 ) R-HSA-4827383 Reaction Name: WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) See in Reactome R-HSA-5638157 ( R-HSA-3214841 ) R-HSA-5638157 Reaction Name: WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) See in Reactome