DAR - Bologna Biocomputing Group

Search summary (EC number: 1.16.3.1)

Number of enzymes:	4
Number of disease:	5
Number of reactomes:	9
Number of reactions:	15

Search results (EC number: 1.16.3.1)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009245	FXN	Q16595	1.16.3.1	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-1362409 R-HSA-1362409 Reactome Name: Mitochondrial iron-sulfur cluster biogenesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-1299475 ( R-HSA-1268020 ) R-HSA-1299475 Reaction Name: TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix See in Reactome R-HSA-1299478 ( R-HSA-1268020 ) R-HSA-1299478 Reaction Name: MPP cleaves targeting peptide (presequence) of matrix precursors See in Reactome R-HSA-1299480 ( R-HSA-1268020 ) R-HSA-1299480 Reaction Name: Precursor proteins enter TIMM23 PAM See in Reactome R-HSA-1362408 ( R-HSA-1362409 ) R-HSA-1362408 Reaction Name: FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster See in Reactome R-HSA-1362416 ( R-HSA-1362409 ) R-HSA-1362416 Reaction Name: Frataxin binds iron See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome
MONDO:0009871	HEPHL1	Q6MZM0	1.16.3.1
MONDO:0011426	CP	P00450	1.16.3.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-425410 R-HSA-425410 Reactome Name: Metal ion SLC transporters See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-425366 R-HSA-425366 Reactome Name: Transport of bile salts and organic acids, metal ions and amine compounds See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism of proteins Transport of small molecules	R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-904830 ( R-HSA-425410; R-HSA-917937 ) R-HSA-904830 Reaction Name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region See in Reactome R-HSA-917891 ( R-HSA-917937 ) R-HSA-917891 Reaction Name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ See in Reactome
MONDO:0014225	FTH1	P02794	1.16.3.1	R-HSA-3000480 R-HSA-3000480 Reactome Name: Scavenging by Class A Receptors See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Transport of small molecules Vesicle-mediated transport	R-HSA-1562626 ( R-HSA-917937 ) R-HSA-1562626 Reaction Name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) See in Reactome R-HSA-2187266 ( R-HSA-3000480 ) R-HSA-2187266 Reaction Name: SCARA5 binds ligands See in Reactome R-HSA-2299677 ( R-HSA-3000480 ) R-HSA-2299677 Reaction Name: SCARA5:ligand is endocytosed See in Reactome R-HSA-434362 ( R-HSA-432722 ) R-HSA-434362 Reaction Name: Recruitment Of Cytoplasmic Proteins To Vesicles See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0100340	FXN	Q16595	1.16.3.1	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-1362409 R-HSA-1362409 Reactome Name: Mitochondrial iron-sulfur cluster biogenesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-1299475 ( R-HSA-1268020 ) R-HSA-1299475 Reaction Name: TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix See in Reactome R-HSA-1299478 ( R-HSA-1268020 ) R-HSA-1299478 Reaction Name: MPP cleaves targeting peptide (presequence) of matrix precursors See in Reactome R-HSA-1299480 ( R-HSA-1268020 ) R-HSA-1299480 Reaction Name: Precursor proteins enter TIMM23 PAM See in Reactome R-HSA-1362408 ( R-HSA-1362409 ) R-HSA-1362408 Reaction Name: FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster See in Reactome R-HSA-1362416 ( R-HSA-1362409 ) R-HSA-1362416 Reaction Name: Frataxin binds iron See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome