DAR - Bologna Biocomputing Group

Search summary (EC number: 1.15.1.1)

Number of enzymes:	2
Number of disease:	3
Number of reactomes:	5
Number of reactions:	13

Search results (EC number: 1.15.1.1)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007103	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome
MONDO:0012970	SOD2	P04179	1.15.1.1	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Organelle biogenesis and maintenance Immune System	R-HSA-3299680 ( R-HSA-3299685 ) R-HSA-3299680 Reaction Name: SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617941 ( R-HSA-8950505 ) R-HSA-9617941 Reaction Name: Expression of superoxide dismutase 2 See in Reactome
MONDO:0032828	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome