DAR - Bologna Biocomputing Group

Search summary (EC number: 1.14.14.18)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	8
Number of reactions:	14

Search results (EC number: 1.14.14.18)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013536	HMOX1	P09601	1.14.14.18	R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-9707587 R-HSA-9707587 Reactome Name: Regulation of HMOX1 expression and activity See in Reactome R-HSA-844456 R-HSA-844456 Reactome Name: The NLRP3 inflammasome See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9609523 R-HSA-9609523 Reactome Name: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-622312 R-HSA-622312 Reactome Name: Inflammasomes See in Reactome	Cellular responses to stimuli Protein localization Immune System Transport of small molecules Metabolism	R-HSA-1250272 ( R-HSA-844456; R-HSA-9707564 ) R-HSA-1250272 Reaction Name: TXNIP binds NLRP3 See in Reactome R-HSA-189398 ( R-HSA-189483; R-HSA-917937; R-HSA-9707564 ) R-HSA-189398 Reaction Name: HMOX1 dimer, HMOX2 cleave heme See in Reactome R-HSA-6797268 ( R-HSA-6785807 ) R-HSA-6797268 Reaction Name: Expression of HMOX1 See in Reactome R-HSA-9609860 ( R-HSA-9609523 ) R-HSA-9609860 Reaction Name: Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP See in Reactome R-HSA-9609899 ( R-HSA-9609523 ) R-HSA-9609899 Reaction Name: Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane See in Reactome R-HSA-9609917 ( R-HSA-9609523 ) R-HSA-9609917 Reaction Name: Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane See in Reactome R-HSA-9609921 ( R-HSA-9609523 ) R-HSA-9609921 Reaction Name: SGTA binds Tail-anchored protein See in Reactome R-HSA-9610442 ( R-HSA-9609523 ) R-HSA-9610442 Reaction Name: Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP See in Reactome R-HSA-9707645 ( R-HSA-9707564; R-HSA-9707587; R-HSA-9707616 ) R-HSA-9707645 Reaction Name: HMOX1 gene produces HMOX1 dimer See in Reactome R-HSA-9708457 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708457 Reaction Name: HM13 cleaves HMOX1 dimer See in Reactome R-HSA-9708536 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708536 Reaction Name: HMOX1 translocates from the cytosol to the nucleoplasm See in Reactome R-HSA-9708558 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708558 Reaction Name: HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane See in Reactome R-HSA-9709918 ( R-HSA-9707564 ) R-HSA-9709918 Reaction Name: PTK6 phosphorylates STAT3 See in Reactome R-HSA-9759176 () R-HSA-9759176 Reaction Name: NFE2L2-dependent HMOX1 gene expression See in Reactome